ADNI Longitudinal Summaries

ATRI Biostatistics

ADNI enrollment summaries using the ADNIMERGE R package

Description

This package vignette demonstrates how to use the ADNIMERGE package to simple longitudinal summaries and plots with R and knitr.

Report generated from Enrollment.Rmd

Load required R packages and functions

options(digits = 3)
library(knitr)
library(ADNIMERGE)
library(ggplot2)
library(Hmisc)
library(gridExtra)
library(RColorBrewer)
library(patchwork)

library(tidyverse)
library(kableExtra)
source("https://adni.bitbucket.io/myfunctions.R")
theme_set(theme_bw())
dx3pal <- c("#2b8cbe", "#fc8d59", "#e34a33")
scale_colour_discrete <- function(...) scale_colour_manual(..., values = dx3pal)
scale_fill_discrete <- function(...) scale_fill_manual(..., values = dx3pal)

Cognitive Outcomes

ADAS 13 change from baseline

Month N Min. NA. Median Mean Max.
CN
6 490 -13.00 0 0.00e+00 -0.191 11.67
12 472 -12.33 0 -3.40e-01 -0.497 12.67
24 564 -10.33 0 0.00e+00 -0.131 15.67
30 28 -5.67 0 3.30e-01 0.488 7.00
36 242 -11.34 0 0.00e+00 0.167 26.00
42 8 -6.67 0 1.33e+00 0.624 7.00
48 317 -8.00 0 3.30e-01 0.862 28.67
54 24 -8.33 0 6.70e-01 0.182 8.00
60 136 -7.67 0 6.70e-01 1.534 22.67
66 51 -5.67 0 -6.70e-01 -0.223 9.00
72 177 -7.00 0 1.00e+00 2.162 33.67
78 43 -6.33 0 1.00e+00 1.170 14.67
84 118 -8.67 0 1.67e+00 3.365 27.33
90 38 -6.67 0 1.67e+00 1.518 11.00
96 109 -9.33 0 3.00e+00 4.315 42.67
102 20 -3.67 0 2.00e+00 2.333 8.33
108 67 -5.33 0 3.33e+00 6.901 70.67
114 12 -5.00 0 0.00e+00 1.639 19.00
120 63 -6.00 0 3.00e+00 5.243 43.67
126 11 -2.33 0 3.67e+00 3.880 13.67
132 27 -3.34 0 3.33e+00 5.284 28.67
138 9 -9.34 0 8.66e+00 12.702 44.67
144 22 -3.67 0 5.00e+00 6.787 24.67
150 9 -6.33 0 7.33e+00 13.852 61.34
156 22 -2.00 0 4.00e+00 6.758 26.33
162 9 -2.67 0 5.33e+00 14.666 53.00
168 5 -4.34 0 2.33e+00 1.332 6.00
180 13 -2.00 0 2.33e+00 4.204 26.00
Dementia
6 800 -15.33 0 0.00e+00 0.493 17.66
12 899 -15.00 0 3.30e-01 0.714 54.00
18 325 -14.00 0 2.67e+00 2.976 28.33
24 722 -12.00 0 1.67e+00 2.331 42.33
30 11 -4.00 0 6.00e+00 6.122 20.00
36 597 -14.00 0 2.00e+00 3.634 49.00
MCI
42 5 -8.00 0 -1.33e+00 -0.400 6.67
48 401 -14.33 0 3.00e+00 4.919 55.00
54 6 -3.67 0 2.67e+00 5.055 16.67
60 239 -14.33 0 3.67e+00 6.679 71.00
66 31 -8.00 0 1.33e+00 4.044 30.00
72 173 -17.33 0 4.33e+00 6.909 61.33
78 37 -7.00 0 3.30e-01 2.792 38.67
84 131 -11.67 0 4.00e+00 6.840 53.67
90 41 -7.67 0 2.00e+00 2.521 20.00
96 94 -11.00 0 4.00e+00 7.592 59.00
102 33 -8.00 0 1.33e+00 1.838 21.00
108 61 -10.67 0 6.70e-01 4.781 28.33
114 21 -7.33 0 3.30e-01 1.270 14.00
120 42 -10.00 0 2.33e+00 5.754 38.67
126 16 -10.67 0 8.88e-16 3.458 27.00
132 17 -6.00 0 3.00e+00 5.117 28.67
138 12 -10.33 0 5.33e+00 8.138 21.67
144 7 -4.66 0 3.67e+00 8.050 39.67
150 8 -12.33 0 -1.65e-01 1.834 22.67
6 298 -12.00 0 2.34e+00 2.501 23.00
12 294 -13.00 0 3.67e+00 4.895 31.00
18 6 -4.67 0 2.16e+00 11.055 45.67
24 170 -5.67 0 8.00e+00 10.195 37.00
30 5 -1.67 0 5.67e+00 6.602 12.67
36 11 3.67 0 9.34e+00 13.910 35.33

MMSE change from baseline

Month N Min. NA. Median Mean Max.
CN
6 494 -5 0 0.0 -0.0729 4
12 478 -8 0 0.0 -0.1109 4
24 573 -24 0 0.0 -0.1658 4
30 29 -3 0 0.0 -0.2069 2
36 248 -9 0 0.0 -0.2500 4
42 8 0 0 0.0 0.5000 2
48 320 -14 0 0.0 -0.3000 4
54 23 -2 0 0.0 0.1739 3
60 137 -10 0 0.0 -0.2993 5
66 51 -6 0 0.0 -0.2157 4
72 175 -8 0 0.0 -0.4000 5
78 43 -8 0 0.0 -0.5116 3
84 118 -12 0 0.0 -0.8983 3
90 39 -4 0 0.0 -0.5897 4
96 109 -18 0 0.0 -1.1284 4
102 21 -5 0 0.0 -0.4762 3
108 67 -17 0 0.0 -1.6866 5
114 13 -11 0 -1.0 -1.6923 1
120 61 -21 0 -1.0 -1.5902 3
126 11 -4 0 -1.0 -0.8182 1
132 28 -5 0 -1.0 -0.7143 4
138 10 -17 0 -2.0 -5.3000 0
144 22 -9 0 -1.0 -1.4091 3
150 10 -23 0 -1.0 -6.5000 1
156 23 -9 0 0.0 -0.7826 3
162 9 -18 0 0.0 -4.3333 1
168 5 0 0 0.0 0.6000 2
180 13 -6 0 -1.0 -1.1538 2
Dementia
6 808 -10 0 0.0 -0.5087 5
12 907 -12 0 0.0 -0.5788 6
18 329 -15 0 -1.0 -1.1824 5
24 736 -19 0 -1.0 -1.2418 6
30 10 -7 0 -2.5 -2.8000 3
36 609 -23 0 -1.0 -1.7816 6
MCI
48 407 -20 0 -1.0 -2.2703 5
54 6 -5 0 -3.0 -2.5000 1
60 243 -30 0 -1.0 -2.8107 5
66 34 -15 0 -1.0 -2.3824 4
72 174 -25 0 -2.0 -3.3563 5
78 40 -16 0 -1.0 -1.5750 4
84 135 -24 0 -1.0 -2.7333 5
90 44 -20 0 -0.5 -1.9773 6
96 97 -21 0 -1.0 -3.2784 4
102 34 -9 0 -1.0 -0.9412 5
108 66 -20 0 -1.0 -2.9242 3
114 21 -4 0 -1.0 -1.0476 4
120 43 -16 0 0.0 -2.0000 3
126 16 -9 0 -1.0 -1.9375 2
132 18 -13 0 -0.5 -2.3333 2
138 12 -11 0 -2.5 -2.9167 7
144 7 -16 0 0.0 -4.1429 1
150 8 -10 0 0.5 -0.3750 3
6 312 -16 0 -1.0 -1.1410 8
12 306 -18 0 -2.0 -2.3529 5
18 7 -19 0 -3.0 -7.2857 0
24 187 -22 0 -3.0 -4.4545 5
30 5 -8 0 -2.0 -2.4000 2
36 13 -22 0 -5.0 -8.0769 1

CDR-SB change from baseline

Month N Min. NA. Median Mean Max.
CN
6 490 -1.0 0 0.00 0.0745 4.0
12 472 -1.0 0 0.00 0.1006 4.0
24 591 -1.0 0 0.00 0.1497 5.0
30 31 -0.5 0 0.00 0.2258 3.5
36 240 -0.5 0 0.00 0.2896 6.0
42 9 0.0 0 0.00 0.0000 0.0
48 316 -0.5 0 0.00 0.2563 5.5
54 22 -0.5 0 0.00 0.1591 1.5
60 143 -0.5 0 0.00 0.4301 11.0
66 54 -0.5 0 0.00 0.4352 5.5
72 180 -0.5 0 0.00 0.4722 7.0
78 50 -0.5 0 0.00 0.6200 10.0
84 128 -0.5 0 0.00 0.8789 16.0
90 42 0.0 0 0.00 0.7143 12.0
96 115 -0.5 0 0.00 1.0652 13.0
102 31 0.0 0 0.00 1.0000 15.5
108 74 0.0 0 0.50 1.8243 18.0
114 17 0.0 0 0.00 1.0882 9.0
120 64 0.0 0 0.00 1.4844 17.5
126 12 0.0 0 0.25 0.7083 3.0
132 30 0.0 0 0.00 0.5833 6.0
138 12 0.0 0 1.00 4.5000 17.0
144 23 0.0 0 0.00 1.2826 8.0
150 12 0.0 0 1.00 4.8333 15.0
156 24 0.0 0 0.25 1.2708 7.0
162 10 0.0 0 0.75 6.8500 18.0
168 9 0.0 0 0.50 1.5000 8.0
180 15 0.0 0 0.00 1.1000 11.0
186 6 0.0 0 0.00 0.4167 2.5
Dementia
6 804 -3.5 0 0.00 0.2363 8.0
12 907 -3.0 0 0.00 0.3699 8.0
18 329 -2.0 0 0.50 0.9726 9.0
24 748 -3.0 0 0.50 0.9305 11.5
30 12 -0.5 0 0.00 0.6250 3.0
36 617 -3.5 0 0.50 1.3476 12.5
MCI
42 5 -1.0 0 -0.50 -0.3000 1.0
48 412 -3.5 0 0.50 1.7112 16.0
54 6 -1.0 0 1.25 1.0000 2.5
60 254 -3.0 0 1.00 2.2992 16.0
66 36 -3.0 0 0.50 1.9861 15.0
72 187 -3.0 0 1.50 2.9652 16.0
78 42 -2.0 0 0.00 1.5357 15.5
84 150 -3.0 0 1.00 3.0067 17.0
90 45 -3.5 0 0.00 0.6889 12.5
96 117 -2.5 0 1.00 3.0128 16.0
102 37 -3.5 0 -0.50 0.4189 9.5
108 86 -2.5 0 1.00 3.2093 16.5
114 22 -1.0 0 -0.25 1.2500 14.5
120 55 -1.5 0 0.00 1.9636 16.5
126 17 -1.0 0 0.00 1.7059 15.0
132 22 -2.5 0 0.75 2.4545 17.0
138 13 -1.5 0 1.00 2.4231 9.5
144 10 -1.0 0 6.00 7.2000 16.5
150 10 -1.5 0 -0.50 0.9500 8.5
6 311 -3.0 0 0.50 0.7974 9.0
12 313 -3.0 0 1.00 1.7364 11.5
18 8 -0.5 0 3.00 4.1250 13.0
24 190 -3.0 0 3.00 3.4184 14.0
30 5 0.5 0 2.00 3.4000 11.5
36 14 -0.5 0 6.50 6.0714 12.0

Pt ECog - Mem change from baseline

Month N Min. NA. Median Mean Max.
CN
6 273 -1.500 0 0.000 0.03031 1.625
12 269 -1.375 0 0.000 0.01965 1.625
24 402 -2.000 0 0.000 0.02230 1.750
30 33 -0.750 0 -0.125 -0.10606 0.625
36 61 -0.589 0 0.000 0.03132 1.250
42 9 -0.875 0 -0.125 -0.27116 0.000
48 202 -1.375 0 0.000 0.04500 2.125
54 25 -1.429 0 0.125 0.20643 1.375
60 31 -1.000 0 0.125 0.14343 1.000
66 54 -1.000 0 0.107 0.12566 1.250
72 63 -0.750 0 0.125 0.16808 1.625
78 50 -1.321 0 0.107 0.14405 1.625
84 26 -1.500 0 0.250 0.18521 1.821
90 42 -0.714 0 0.000 0.11480 1.500
96 44 -1.125 0 0.188 0.26502 1.857
102 30 -0.750 0 0.125 0.29167 2.250
108 12 -0.375 0 0.125 0.31250 1.250
114 16 -0.375 0 0.125 0.17076 1.375
120 17 -1.125 0 0.125 0.07353 0.875
126 10 -0.625 0 0.188 0.34821 1.500
Dementia
6 428 -2.125 0 -0.125 -0.10402 1.625
12 555 -2.250 0 0.000 -0.05281 1.750
18 8 -1.250 0 -0.214 -0.16295 0.875
MCI
24 449 -2.875 0 0.000 -0.03188 2.500
30 12 -0.750 0 0.250 0.32738 1.250
36 360 -2.375 0 0.000 -0.02789 2.500
42 5 -1.375 0 -0.625 -0.22500 1.500
48 257 -2.500 0 -0.125 -0.09913 2.357
54 6 -0.661 0 -0.188 -0.19345 0.125
60 124 -1.500 0 0.000 0.00974 1.375
66 33 -1.250 0 -0.125 -0.02183 1.750
72 66 -1.750 0 0.000 0.07359 1.750
78 38 -2.125 0 -0.125 -0.02538 2.000
84 56 -2.375 0 -0.125 -0.07058 1.625
90 45 -1.375 0 -0.125 -0.05317 2.214
96 41 -2.500 0 -0.250 -0.18902 1.625
102 36 -2.250 0 -0.125 -0.22173 1.250
108 33 -2.250 0 -0.125 -0.08081 1.875
114 23 -1.375 0 0.000 0.14130 1.375
120 27 -1.875 0 0.000 -0.00265 1.625
126 12 -1.250 0 -0.312 -0.01190 1.375
132 11 -1.500 0 -0.375 -0.36526 1.625
6 124 -1.875 0 0.000 -0.05921 1.750
12 131 -2.000 0 0.000 -0.12325 2.000
24 41 -1.750 0 -0.125 -0.10192 2.125

SP ECog - Mem change from baseline

Month N Min. NA. Median Mean Max.
CN
6 263 -1.375 0 0.0000 0.01722 1.625
12 263 -1.500 0 0.0000 0.03849 2.125
24 385 -1.500 0 0.0000 0.04771 2.125
30 31 -0.375 0 0.0000 0.12154 2.125
36 57 -1.375 0 0.0000 0.12901 2.125
42 9 -0.714 0 0.0000 -0.03175 0.429
48 193 -1.250 0 0.0000 0.10848 2.500
54 24 -0.500 0 0.0625 0.16295 1.042
60 30 -0.750 0 0.0000 0.18770 2.464
66 52 -0.625 0 0.1250 0.18681 1.500
72 62 -1.500 0 0.0000 0.23032 2.250
78 52 -2.375 0 0.1250 0.16854 2.750
84 26 -0.750 0 0.0000 0.30288 2.750
90 41 -0.589 0 0.1250 0.31794 2.250
96 40 -1.375 0 0.0000 0.23631 3.000
102 27 -0.500 0 0.0000 0.42593 3.000
108 13 -0.375 0 0.1250 0.55769 2.750
114 16 -0.500 0 0.2500 0.59821 2.750
120 15 -0.625 0 0.0000 0.20238 2.125
126 9 -0.125 0 0.8750 0.74537 1.750
Dementia
6 424 -1.875 0 0.0000 0.00345 2.125
12 549 -2.750 0 0.0000 0.01808 2.250
18 8 -1.750 0 -0.0714 -0.28348 0.250
24 449 -1.875 0 0.0000 0.09842 2.125
MCI
30 12 -1.750 0 0.0625 0.19792 2.125
36 357 -2.250 0 0.1250 0.15905 2.143
42 5 -0.625 0 0.0476 -0.06905 0.357
48 252 -1.750 0 0.1250 0.20394 2.875
54 6 -0.125 0 0.5000 0.58333 1.625
60 120 -1.625 0 0.1250 0.26644 2.500
66 37 -0.875 0 0.1250 0.24356 1.625
72 64 -1.625 0 0.1250 0.24881 2.286
78 43 -1.125 0 0.0000 0.09983 2.000
84 58 -1.125 0 0.1250 0.38378 2.500
90 46 -1.250 0 0.0000 0.10688 2.167
96 41 -1.250 0 0.3750 0.37398 2.375
102 35 -2.000 0 0.0000 0.07449 2.000
108 36 -0.625 0 0.1250 0.35417 2.500
114 23 -0.875 0 0.0000 0.19658 1.643
120 26 -0.500 0 0.0000 0.21360 1.500
126 11 -1.125 0 0.6250 0.28409 1.750
132 11 -1.125 0 -0.0536 0.30519 2.500
6 130 -2.750 0 0.0000 0.04211 1.625
12 151 -1.000 0 0.1250 0.23266 2.125
24 54 -1.750 0 0.1250 0.18022 1.750
30 5 0.000 0 0.2500 0.55000 1.250

Pt ECog - Total change from baseline

Month N Min. NA. Median Mean Max.
CN
6 273 -1.139 0 0.00000 1.78e-02 0.821
12 269 -0.751 0 0.00000 2.71e-02 1.462
24 402 -1.342 0 0.00000 2.11e-02 1.179
30 33 -0.658 0 -0.07895 -9.09e-02 0.421
36 61 -0.526 0 0.00000 6.71e-02 1.237
42 9 -0.658 0 -0.04386 -1.52e-01 0.184
48 203 -0.985 0 0.02564 5.35e-02 1.718
54 25 -0.695 0 0.10526 1.18e-01 0.824
60 31 -0.725 0 0.13158 1.05e-01 0.694
66 54 -0.354 0 0.09582 1.47e-01 0.930
72 63 -1.006 0 0.10661 9.23e-02 1.030
78 50 -0.575 0 0.06078 1.15e-01 1.300
84 26 -0.784 0 0.15605 1.29e-01 1.053
90 42 -0.421 0 0.08401 1.58e-01 1.164
96 44 -1.111 0 0.11167 1.42e-01 1.105
102 30 -0.616 0 0.10819 3.25e-01 2.641
108 12 -0.271 0 0.17645 1.86e-01 0.621
114 16 -0.220 0 0.08820 1.92e-01 0.830
120 17 -1.164 0 0.05398 3.65e-02 0.537
126 10 -0.123 0 0.09709 2.59e-01 0.891
Dementia
6 430 -2.083 0 -0.02632 -3.50e-02 1.590
12 558 -1.692 0 -0.02257 -2.03e-02 1.667
18 8 -0.737 0 0.09211 6.96e-03 0.447
MCI
24 451 -1.688 0 0.00000 2.73e-02 1.735
30 12 -0.500 0 0.14314 1.63e-01 0.763
36 356 -1.734 0 0.02564 4.88e-02 1.989
42 5 -0.658 0 -0.04934 1.23e-01 1.486
48 256 -2.308 0 0.02564 3.24e-02 2.708
54 6 -0.333 0 0.11100 1.80e-01 0.940
60 123 -1.215 0 0.02564 6.30e-02 1.133
66 32 -1.094 0 -0.01008 7.28e-02 1.478
72 66 -0.971 0 0.09419 9.12e-02 0.878
78 38 -1.125 0 -0.01251 4.18e-02 1.596
84 56 -1.065 0 0.00742 3.03e-02 1.383
90 45 -1.094 0 0.02853 7.00e-02 2.589
96 41 -1.094 0 -0.10121 -3.12e-03 1.409
102 36 -0.874 0 0.05115 -4.09e-02 0.615
108 33 -0.862 0 0.00925 5.88e-02 1.473
114 23 -0.884 0 0.18016 2.03e-01 1.112
120 27 -1.365 0 0.04184 4.33e-02 1.383
126 12 -1.474 0 0.16664 1.21e-01 1.358
132 11 -1.392 0 -0.29150 -3.18e-01 0.830
6 120 -1.692 0 0.02315 -1.19e-02 1.513
12 129 -1.380 0 -0.00962 9.59e-05 2.098
24 41 -1.431 0 0.05714 1.06e-01 2.321

SP ECog - Total change from baseline

Month N Min. NA. Median Mean Max.
CN
6 265 -0.8794 0 0.00000 0.00909 0.846
12 263 -1.2051 0 0.00000 0.03792 1.615
24 385 -1.1255 0 0.00000 0.04239 2.000
30 31 -0.3158 0 0.00284 0.04355 1.113
36 57 -1.3300 0 0.05128 0.13448 2.051
42 9 -0.4324 0 0.00000 0.04505 0.237
48 194 -1.0513 0 0.00000 0.08174 2.289
54 24 -0.3183 0 0.07292 0.15518 0.847
60 30 -0.5405 0 0.03975 0.20949 2.538
66 52 -0.5641 0 0.03121 0.13301 1.426
72 61 -0.9939 0 0.05263 0.18249 2.520
78 52 -1.5441 0 0.05263 0.19780 2.947
84 26 -0.6457 0 0.00607 0.27654 2.397
90 41 -0.5641 0 0.09048 0.22968 2.305
96 41 -0.9939 0 0.00000 0.17574 2.474
102 27 -0.1433 0 0.08165 0.33247 2.447
108 13 -0.1102 0 0.26721 0.43386 2.872
114 16 -0.5641 0 0.15688 0.45668 2.735
120 15 -0.4595 0 0.00000 0.04161 0.727
126 9 -0.0294 0 0.70672 0.54997 1.158
Dementia
6 426 -1.4615 0 0.02065 0.05147 1.991
12 549 -2.0388 0 0.05128 0.08818 2.224
18 8 -0.5789 0 -0.00213 -0.01280 0.500
24 450 -1.4103 0 0.11034 0.18574 2.410
MCI
30 12 -0.9211 0 0.28363 0.32844 1.586
36 356 -2.1375 0 0.15385 0.25792 2.513
42 5 -0.0931 0 0.10526 0.10284 0.395
48 252 -2.1147 0 0.14523 0.27626 2.615
54 6 -0.1005 0 0.42689 0.52356 1.318
60 120 -1.0538 0 0.17486 0.30872 2.401
66 37 -0.6606 0 0.22637 0.40747 1.912
72 64 -1.1026 0 0.13839 0.22995 1.830
78 43 -1.0155 0 0.13158 0.29339 2.250
84 58 -1.3448 0 0.16599 0.43692 2.300
90 46 -0.9946 0 0.14782 0.30064 2.400
96 41 -1.0816 0 0.12233 0.47064 2.299
102 35 -1.2051 0 0.22973 0.29869 2.513
108 36 -0.5886 0 0.08536 0.45693 2.819
114 23 -0.4352 0 0.16667 0.32680 1.556
120 26 -0.2598 0 0.02932 0.19987 1.998
126 11 -0.1988 0 0.05331 0.43431 1.517
132 11 -0.5641 0 0.00000 0.26217 1.173
6 130 -2.5000 0 0.12557 0.10533 1.333
12 152 -1.4615 0 0.32895 0.34423 1.571
24 54 -0.6494 0 0.45338 0.46613 2.079
30 5 0.5789 0 0.80105 0.82319 1.105

Biomarkers

Volumetrics

UCSF Hippocampus change from baseline

Month N Min. NA. Median Mean Max.
CN
3 182 -815 0 -18.5 -15.7 756.0
6 329 -1940 0 -30.0 -54.4 758.0
12 385 -1965 0 -66.2 -94.5 774.0
24 434 -1435 0 -167.4 -184.7 2590.0
30 22 -638 0 -229.9 -246.6 90.9
36 139 -1117 0 -245.0 -260.2 622.0
48 200 -3084 0 -349.0 -415.1 744.0
54 12 -662 0 -280.2 -291.7 -41.9
60 79 -1269 0 -412.0 -399.5 655.0
66 33 -1160 0 -450.2 -482.0 265.2
72 113 -1820 0 -485.0 -515.2 395.5
78 27 -1327 0 -495.7 -560.1 158.2
84 29 -2842 0 -435.0 -596.4 148.0
90 24 -1598 0 -635.4 -709.0 133.0
96 41 -2052 0 -609.3 -684.8 100.6
102 9 -946 0 -611.6 -564.9 -230.6
108 17 -1842 0 -490.0 -687.7 209.0
120 17 -2142 0 -814.7 -924.8 -172.5
132 17 -1585 0 -788.6 -675.7 532.4
138 6 -1218 0 -733.9 -688.3 -288.9
144 12 -1535 0 -669.2 -660.1 310.6
156 12 -1367 0 -938.1 -917.3 -231.9
Dementia
3 354 -801 0 -34.0 -30.0 885.0
6 600 -1376 0 -77.5 -68.7 733.0
12 641 -969 0 -152.0 -157.9 630.0
18 205 -966 0 -274.0 -259.7 590.0
MCI
24 513 -2772 0 -292.0 -303.7 456.0
30 6 -817 0 -511.2 -515.3 -332.4
36 230 -1482 0 -430.0 -456.8 548.0
48 232 -2626 0 -558.0 -617.2 479.0
60 101 -2185 0 -649.0 -713.7 240.0
66 18 -1243 0 -664.2 -610.4 349.8
72 95 -2525 0 -729.0 -801.2 394.0
78 28 -1912 0 -630.8 -668.2 523.0
84 54 -2063 0 -641.1 -712.0 409.3
90 28 -2431 0 -647.3 -771.1 151.0
96 35 -2848 0 -868.0 -900.3 440.9
102 21 -2029 0 -646.8 -748.8 5.1
108 22 -2928 0 -679.4 -886.3 304.5
114 8 -2025 0 -837.6 -975.8 -371.4
120 14 -1508 0 -954.4 -914.8 -199.0
126 6 -1387 0 -1282.1 -1144.6 -608.2
132 9 -1130 0 -444.1 -609.5 -162.3
144 6 -1923 0 -667.6 -1020.2 -419.6
3 92 -685 0 -36.0 -30.1 927.0
6 191 -1332 0 -136.0 -116.5 1865.0
12 199 -1562 0 -261.0 -267.2 833.0
24 108 -1109 0 -416.0 -435.1 1375.0

UCSF WholeBrain change from baseline

Month N Min. NA. Median Mean Max.
CN
3 201 -72848 0 -2395 -3018 35447
6 381 -106897 0 -4942 -4579 101877
12 431 -78206 0 -7351 -7196 51519
24 469 -88405 0 -13759 -13156 475649
30 22 -32766 0 -12414 -11120 11604
36 171 -85200 0 -20209 -20227 41140
48 216 -183387 0 -28100 -27806 47403
54 13 -67270 0 -33188 -28837 20498
60 101 -145445 0 -40667 -43638 44628
66 41 -82351 0 -38056 -36903 39906
72 137 -149221 0 -47276 -45401 64655
78 30 -83931 0 -39971 -38238 25986
84 34 -113695 0 -16349 -15831 56739
90 31 -123532 0 -50467 -52030 -5026
96 43 -99261 0 -30573 -27419 41586
102 9 -109557 0 -60404 -61424 -8558
108 20 -83236 0 -31314 -32128 24174
114 5 -87489 0 -52857 -46819 12182
120 15 -94523 0 -45608 -43946 12911
132 19 -86393 0 -27712 -32188 14012
138 8 -80558 0 -49714 -39430 31555
144 14 -97927 0 -43671 -44896 11757
150 7 -109584 0 -44531 -29903 43937
156 13 -96677 0 -54220 -47150 36707
162 5 -82452 0 -18982 -28415 1975
Dementia
3 408 -61742 0 -1967 -1456 40771
6 735 -94640 0 -4878 -5163 92397
12 799 -64433 0 -9768 -9923 55512
18 291 -96551 0 -17402 -17710 57514
MCI
24 606 -318527 0 -18034 -19918 59818
30 7 -54042 0 -30132 -32482 -10890
36 295 -143138 0 -28545 -30960 63734
48 248 -160256 0 -39111 -41811 75934
60 117 -189119 0 -60540 -64531 57796
66 22 -87250 0 -46729 -42516 50524
72 125 -228487 0 -58662 -61269 51610
78 29 -131070 0 -50056 -51909 -10480
84 60 -140790 0 -47730 -43797 30939
90 34 -129225 0 -49424 -54381 32702
96 40 -92770 0 -55517 -50207 20738
102 24 -89664 0 -60276 -60631 -18168
108 27 -152216 0 -59304 -62247 10736
114 9 -86467 0 -59096 -55996 9118
120 16 -95178 0 -66478 -53840 4340
126 8 -164250 0 -51270 -57165 20119
132 10 -87434 0 -37822 -41005 -911
138 6 -68077 0 -30374 -35819 -22531
144 6 -116380 0 -41554 -53921 4695
150 6 -70254 0 -35232 -37728 -7701
3 103 -49206 0 -5850 -5798 22851
6 262 -77681 0 -9585 -9763 80065
12 253 -86270 0 -18033 -17425 62386
24 139 -87554 0 -33646 -31828 32486

UCSF Entorhinal change from baseline

Month N Min. NA. Median Mean Max.
CN
3 181 -1224 0 6.0 -51.49 694
6 331 -1561 0 -34.0 -52.06 1535
12 368 -1234 0 -58.5 -59.37 1304
24 400 -1086 0 -81.0 -67.86 1364
30 22 -769 0 -40.0 -82.86 639
36 139 -1113 0 -98.0 -99.55 868
48 178 -1491 0 -142.5 -94.52 1269
54 11 -60 0 316.0 386.82 861
60 76 -1744 0 -143.0 -185.05 1310
66 38 -735 0 202.0 307.89 2169
72 112 -1089 0 -113.5 -116.35 1081
78 27 -780 0 250.0 243.85 1404
84 27 -1218 0 -7.0 -80.70 817
90 28 -1093 0 162.5 139.14 1689
96 39 -1280 0 15.0 -6.85 1213
102 8 -1103 0 262.0 198.38 1547
108 16 -1156 0 -302.5 -205.12 908
114 5 -1620 0 -247.0 -428.80 234
120 14 -973 0 -502.0 -303.93 1087
132 17 -1797 0 119.0 96.41 1384
138 6 -2089 0 -464.0 -519.33 546
144 12 -644 0 2.0 49.25 975
156 12 -1093 0 -105.5 -59.17 1238
Dementia
3 350 -1139 0 -63.0 -36.08 1178
6 585 -1820 0 -49.0 -48.96 1230
12 623 -1856 0 -92.0 -91.81 1461
18 205 -1867 0 -217.0 -197.51 1797
MCI
24 453 -2163 0 -170.0 -179.00 897
30 6 -555 0 -308.0 -346.83 -110
36 212 -2445 0 -280.5 -246.67 853
48 194 -1970 0 -243.5 -320.97 967
60 91 -1421 0 -425.0 -405.59 1647
66 19 -1255 0 -56.0 13.42 1084
72 92 -1897 0 -265.0 -282.03 1218
78 27 -1350 0 33.0 -50.11 1238
84 50 -1655 0 54.5 -38.94 2068
90 28 -1441 0 129.0 -99.64 1003
96 28 -1334 0 155.5 18.50 1186
102 21 -1512 0 197.0 30.14 1237
108 25 -1782 0 230.0 -61.68 1141
114 8 -944 0 -199.5 -51.50 1296
120 13 -2237 0 346.0 218.31 1014
126 5 -1898 0 -748.0 -562.80 1392
132 9 -343 0 157.0 296.00 1060
144 6 -586 0 557.5 485.50 1277
3 75 -809 0 30.0 24.41 632
6 171 -1681 0 -67.0 -27.35 1566
12 172 -1437 0 -160.0 -145.38 1004
24 100 -1224 0 -246.0 -261.47 489