ADNI Longitudinal Summaries

ATRI Biostatistics

ADNI enrollment summaries using the ADNIMERGE R package

Description

This package vignette demonstrates how to use the ADNIMERGE package to simple longitudinal summaries and plots with R and knitr.

Report generated from Enrollment.Rmd

Load required R packages and functions

options(digits = 3)
library(knitr)
library(ADNIMERGE)
library(ggplot2)
library(Hmisc)
library(gridExtra)
library(RColorBrewer)
library(patchwork)

library(tidyverse)
library(kableExtra)
source("https://adni.bitbucket.io/myfunctions.R")
theme_set(theme_bw())
dx3pal <- c("#2b8cbe", "#fc8d59", "#e34a33")
scale_colour_discrete <- function(...) scale_colour_manual(..., values = dx3pal)
scale_fill_discrete <- function(...) scale_fill_manual(..., values = dx3pal)

Cognitive Outcomes

ADAS 13 change from baseline

Month N Min. NA. Median Mean Max.
CN
6 490 -13.00 0 0.000 -0.191 11.67
12 471 -12.33 0 -0.340 -0.506 12.67
24 564 -10.33 0 0.000 -0.131 15.67
30 28 -5.67 0 0.330 0.488 7.00
36 242 -11.34 0 0.000 0.167 26.00
42 8 -6.67 0 1.335 0.624 7.00
48 300 -8.00 0 0.330 0.776 18.33
54 24 -8.33 0 0.670 0.182 8.00
60 136 -7.67 0 0.670 1.534 22.67
66 51 -5.67 0 -0.670 -0.223 9.00
72 177 -7.00 0 1.000 2.162 33.67
78 43 -6.33 0 1.000 1.170 14.67
84 118 -8.67 0 1.670 3.365 27.33
90 38 -6.67 0 1.670 1.518 11.00
96 109 -9.33 0 3.000 4.315 42.67
102 20 -3.67 0 2.000 2.333 8.33
108 65 -5.33 0 3.330 6.908 70.67
114 10 -5.00 0 -0.830 1.534 19.00
120 62 -6.00 0 2.835 5.220 43.67
126 9 -1.34 0 3.670 4.223 13.67
132 27 -3.34 0 3.330 5.284 28.67
138 9 -9.34 0 8.660 12.702 44.67
144 22 -3.67 0 5.000 6.787 24.67
150 9 -6.33 0 7.330 13.852 61.34
156 22 -2.00 0 3.995 6.758 26.33
162 9 -2.67 0 5.330 14.666 53.00
168 5 -4.34 0 2.330 1.332 6.00
180 13 -2.00 0 2.330 4.204 26.00
Dementia
6 800 -15.33 0 0.000 0.493 17.66
12 896 -15.00 0 0.330 0.708 54.00
18 325 -14.00 0 2.670 2.976 28.33
24 722 -12.00 0 1.670 2.331 42.33
30 10 -4.00 0 5.000 5.767 20.00
36 596 -14.00 0 2.000 3.613 49.00
MCI
48 400 -14.33 0 3.000 4.940 55.00
54 6 -3.67 0 2.665 5.055 16.67
60 239 -14.33 0 3.670 6.679 71.00
66 31 -8.00 0 1.330 4.044 30.00
72 173 -17.33 0 4.330 6.909 61.33
78 37 -7.00 0 0.330 2.792 38.67
84 131 -11.67 0 4.000 6.840 53.67
90 41 -7.67 0 2.000 2.521 20.00
96 94 -11.00 0 4.000 7.592 59.00
102 33 -8.00 0 1.330 1.838 21.00
108 61 -10.67 0 0.670 4.781 28.33
114 20 -7.33 0 0.830 1.467 14.00
120 39 -10.00 0 2.670 6.239 38.67
126 14 -10.67 0 1.165 4.332 27.00
132 15 -6.00 0 3.000 5.511 28.67
138 10 -10.33 0 5.330 7.633 21.67
144 7 -4.66 0 3.670 8.050 39.67
150 8 -12.33 0 -0.165 1.834 22.67
6 298 -12.00 0 2.335 2.501 23.00
12 293 -13.00 0 3.670 4.825 31.00
18 6 -4.67 0 2.165 11.055 45.67
24 170 -5.67 0 8.000 10.195 37.00
30 5 -1.67 0 5.670 6.602 12.67
36 11 3.67 0 9.340 13.910 35.33

MMSE change from baseline

Month N Min. NA. Median Mean Max.
CN
6 494 -5 0 0.0 -0.0729 4
12 477 -8 0 0.0 -0.1132 4
24 573 -24 0 0.0 -0.1658 4
30 29 -3 0 0.0 -0.2069 2
36 248 -9 0 0.0 -0.2500 4
42 8 0 0 0.0 0.5000 2
48 303 -13 0 0.0 -0.2442 4
54 23 -2 0 0.0 0.1739 3
60 137 -10 0 0.0 -0.2993 5
66 51 -6 0 0.0 -0.2157 4
72 175 -8 0 0.0 -0.4000 5
78 43 -8 0 0.0 -0.5116 3
84 118 -12 0 0.0 -0.8983 3
90 39 -4 0 0.0 -0.5897 4
96 109 -18 0 0.0 -1.1284 4
102 21 -5 0 0.0 -0.4762 3
108 65 -17 0 0.0 -1.7231 5
114 11 -11 0 -1.0 -1.9091 1
120 60 -21 0 -1.0 -1.6167 3
126 9 -2 0 -1.0 -0.5556 1
132 28 -5 0 -1.0 -0.7143 4
138 10 -17 0 -2.0 -5.3000 0
144 22 -9 0 -1.0 -1.4091 3
150 10 -23 0 -1.0 -6.5000 1
156 23 -9 0 0.0 -0.7826 3
162 9 -18 0 0.0 -4.3333 1
168 5 0 0 0.0 0.6000 2
180 13 -6 0 -1.0 -1.1538 2
Dementia
6 808 -10 0 0.0 -0.5087 5
12 904 -12 0 0.0 -0.5763 6
18 329 -15 0 -1.0 -1.1824 5
24 735 -19 0 -1.0 -1.2476 6
30 9 -7 0 -2.0 -2.7778 3
36 608 -23 0 -1.0 -1.7730 6
MCI
48 406 -20 0 -1.0 -2.2709 5
54 6 -5 0 -3.0 -2.5000 1
60 243 -30 0 -1.0 -2.8107 5
66 34 -15 0 -1.0 -2.3824 4
72 174 -25 0 -2.0 -3.3563 5
78 40 -16 0 -1.0 -1.5750 4
84 135 -24 0 -1.0 -2.7333 5
90 44 -20 0 -0.5 -1.9773 6
96 97 -21 0 -1.0 -3.2784 4
102 34 -9 0 -1.0 -0.9412 5
108 66 -20 0 -1.0 -2.9242 3
114 20 -4 0 -1.0 -1.1000 4
120 40 -16 0 -0.5 -2.2250 3
126 14 -9 0 -1.0 -2.0714 2
132 16 -13 0 -0.5 -2.4375 2
138 10 -11 0 -2.0 -2.7000 7
144 7 -16 0 0.0 -4.1429 1
150 8 -10 0 0.5 -0.3750 3
6 312 -16 0 -1.0 -1.1410 8
12 305 -18 0 -2.0 -2.3311 5
18 7 -19 0 -3.0 -7.2857 0
24 187 -22 0 -3.0 -4.4545 5
30 5 -8 0 -2.0 -2.4000 2
36 13 -22 0 -5.0 -8.0769 1

CDR-SB change from baseline

Month N Min. NA. Median Mean Max.
CN
6 490 -1.0 0 0.00 0.0745 4.0
12 471 -1.0 0 0.00 0.1008 4.0
24 590 -1.0 0 0.00 0.1492 5.0
30 31 -0.5 0 0.00 0.2258 3.5
36 240 -0.5 0 0.00 0.2896 6.0
42 9 0.0 0 0.00 0.0000 0.0
48 298 -0.5 0 0.00 0.2366 5.0
54 22 -0.5 0 0.00 0.1591 1.5
60 143 -0.5 0 0.00 0.4301 11.0
66 54 -0.5 0 0.00 0.4352 5.5
72 180 -0.5 0 0.00 0.4722 7.0
78 50 -0.5 0 0.00 0.6200 10.0
84 128 -0.5 0 0.00 0.8789 16.0
90 42 0.0 0 0.00 0.7143 12.0
96 115 -0.5 0 0.00 1.0652 13.0
102 31 0.0 0 0.00 1.0000 15.5
108 72 0.0 0 0.50 1.8333 18.0
114 16 0.0 0 0.00 1.1562 9.0
120 64 0.0 0 0.00 1.4844 17.5
126 10 0.0 0 0.00 0.5000 1.5
132 30 0.0 0 0.00 0.5833 6.0
138 12 0.0 0 1.00 4.5000 17.0
144 23 0.0 0 0.00 1.2826 8.0
150 12 0.0 0 1.00 4.8333 15.0
156 24 0.0 0 0.25 1.2708 7.0
162 10 0.0 0 0.75 6.8500 18.0
168 9 0.0 0 0.50 1.5000 8.0
180 15 0.0 0 0.00 1.1000 11.0
186 5 0.0 0 0.00 0.0000 0.0
Dementia
6 804 -3.5 0 0.00 0.2363 8.0
12 906 -3.0 0 0.00 0.3703 8.0
18 329 -2.0 0 0.50 0.9726 9.0
24 747 -3.0 0 0.50 0.9317 11.5
30 10 -0.5 0 0.25 0.8000 3.0
36 616 -3.5 0 0.50 1.3344 12.5
MCI
48 411 -3.5 0 0.50 1.7153 16.0
54 6 -1.0 0 1.25 1.0000 2.5
60 253 -3.0 0 1.00 2.3103 16.0
66 36 -3.0 0 0.50 1.9861 15.0
72 187 -3.0 0 1.50 2.9652 16.0
78 42 -2.0 0 0.00 1.5357 15.5
84 150 -3.0 0 1.00 3.0067 17.0
90 45 -3.5 0 0.00 0.6889 12.5
96 117 -2.5 0 1.00 3.0128 16.0
102 37 -3.5 0 -0.50 0.4189 9.5
108 86 -2.5 0 1.00 3.2093 16.5
114 21 -1.0 0 0.00 1.3333 14.5
120 52 -1.5 0 0.50 2.1154 16.5
126 15 -1.0 0 0.50 2.0333 15.0
132 19 -2.5 0 0.50 2.6316 17.0
138 12 -1.5 0 1.75 2.7083 9.5
144 10 -1.0 0 6.00 7.2000 16.5
150 10 -1.5 0 -0.50 0.9500 8.5
6 311 -3.0 0 0.50 0.7974 9.0
12 313 -3.0 0 1.00 1.7364 11.5
18 8 -0.5 0 3.00 4.1250 13.0
24 190 -3.0 0 3.00 3.4184 14.0
30 5 0.5 0 2.00 3.4000 11.5
36 14 -0.5 0 6.50 6.0714 12.0

Pt ECog - Mem change from baseline

Month N Min. NA. Median Mean Max.
CN
6 273 -1.500 0 0.0000 0.0303 1.625
12 268 -1.375 0 0.0000 0.0193 1.625
24 402 -2.000 0 0.0000 0.0223 1.750
30 33 -0.750 0 -0.1250 -0.1061 0.625
36 61 -0.589 0 0.0000 0.0313 1.250
42 9 -0.875 0 -0.1250 -0.2712 0.000
48 185 -1.375 0 0.0000 0.0397 2.125
54 25 -1.429 0 0.1250 0.2064 1.375
60 31 -1.000 0 0.1250 0.1434 1.000
66 54 -1.000 0 0.1071 0.1257 1.250
72 63 -0.750 0 0.1250 0.1681 1.625
78 50 -1.321 0 0.1071 0.1440 1.625
84 26 -1.500 0 0.2500 0.1852 1.821
90 42 -0.714 0 0.0000 0.1148 1.500
96 44 -1.125 0 0.1875 0.2650 1.857
102 30 -0.750 0 0.1250 0.2917 2.250
108 10 -0.375 0 0.1250 0.2750 1.250
114 14 -0.375 0 0.1250 0.1594 1.375
120 16 -1.125 0 0.1250 0.0781 0.875
126 8 -0.625 0 0.1250 0.1384 1.125
Dementia
6 428 -2.125 0 -0.1250 -0.1040 1.625
12 554 -2.250 0 0.0000 -0.0534 1.750
18 8 -1.250 0 -0.2143 -0.1629 0.875
MCI
24 448 -2.875 0 0.0000 -0.0314 2.500
30 11 -0.750 0 0.2500 0.3344 1.250
36 359 -2.375 0 0.0000 -0.0314 2.500
48 256 -2.500 0 -0.1250 -0.0971 2.357
54 6 -0.661 0 -0.1875 -0.1935 0.125
60 123 -1.500 0 0.0000 0.0180 1.375
66 33 -1.250 0 -0.1250 -0.0218 1.750
72 66 -1.750 0 0.0000 0.0736 1.750
78 38 -2.125 0 -0.1250 -0.0254 2.000
84 56 -2.375 0 -0.1250 -0.0706 1.625
90 45 -1.375 0 -0.1250 -0.0532 2.214
96 41 -2.500 0 -0.2500 -0.1890 1.625
102 36 -2.250 0 -0.1250 -0.2217 1.250
108 33 -2.250 0 -0.1250 -0.0808 1.875
114 22 -1.375 0 0.0000 0.0909 1.375
120 24 -1.875 0 -0.0982 -0.0290 1.625
126 10 -1.250 0 -0.3125 -0.0893 1.375
132 9 -1.500 0 -0.3750 -0.1964 1.625
6 124 -1.875 0 0.0000 -0.0592 1.750
12 130 -2.000 0 -0.0179 -0.1253 2.000
24 41 -1.750 0 -0.1250 -0.1019 2.125

SP ECog - Mem change from baseline

Month N Min. NA. Median Mean Max.
CN
6 263 -1.375 0 0.0000 0.01722 1.625
12 262 -1.500 0 0.0000 0.04007 2.125
24 385 -1.500 0 0.0000 0.04771 2.125
30 31 -0.375 0 0.0000 0.12154 2.125
36 57 -1.375 0 0.0000 0.12901 2.125
42 9 -0.714 0 0.0000 -0.03175 0.429
48 176 -1.250 0 0.0000 0.09755 2.125
54 24 -0.500 0 0.0625 0.16295 1.042
60 30 -0.750 0 0.0000 0.18770 2.464
66 52 -0.625 0 0.1250 0.18681 1.500
72 62 -1.500 0 0.0000 0.23032 2.250
78 52 -2.375 0 0.1250 0.16854 2.750
84 26 -0.750 0 0.0000 0.30288 2.750
90 41 -0.589 0 0.1250 0.31794 2.250
96 40 -1.375 0 0.0000 0.23631 3.000
102 27 -0.500 0 0.0000 0.42593 3.000
108 11 -0.375 0 0.1250 0.48864 2.750
114 15 -0.500 0 0.2500 0.62143 2.750
120 15 -0.625 0 0.0000 0.20238 2.125
126 8 -0.125 0 0.6250 0.71354 1.750
Dementia
6 424 -1.875 0 0.0000 0.00345 2.125
12 548 -2.750 0 0.0000 0.01583 2.250
18 8 -1.750 0 -0.0714 -0.28348 0.250
24 448 -1.875 0 0.0000 0.09864 2.125
MCI
30 11 -1.750 0 0.0000 0.17045 2.125
36 356 -2.250 0 0.1250 0.15739 2.143
48 251 -1.750 0 0.1250 0.20724 2.875
54 6 -0.125 0 0.5000 0.58333 1.625
60 119 -1.625 0 0.1250 0.26598 2.500
66 37 -0.875 0 0.1250 0.24356 1.625
72 64 -1.625 0 0.1250 0.24881 2.286
78 43 -1.125 0 0.0000 0.09983 2.000
84 58 -1.125 0 0.1250 0.38378 2.500
90 46 -1.250 0 0.0000 0.10688 2.167
96 41 -1.250 0 0.3750 0.37398 2.375
102 35 -2.000 0 0.0000 0.07449 2.000
108 36 -0.625 0 0.1250 0.35417 2.500
114 22 -0.875 0 0.0000 0.19984 1.643
120 23 -0.500 0 0.0000 0.23602 1.500
126 9 -1.125 0 0.6250 0.44444 1.750
132 8 -0.714 0 -0.0893 0.27902 2.500
6 130 -2.750 0 0.0000 0.04211 1.625
12 150 -1.000 0 0.1250 0.22337 2.125
24 54 -1.750 0 0.1250 0.18022 1.750
30 5 0.000 0 0.2500 0.55000 1.250

Pt ECog - Total change from baseline

Month N Min. NA. Median Mean Max.
CN
6 273 -1.1393 0 0.00000 0.01780 0.821
12 268 -0.7510 0 0.00000 0.02715 1.462
24 402 -1.3421 0 0.00000 0.02114 1.179
30 33 -0.6579 0 -0.07895 -0.09087 0.421
36 61 -0.5263 0 0.00000 0.06711 1.237
42 9 -0.6579 0 -0.04386 -0.15249 0.184
48 186 -0.9854 0 0.02564 0.04575 1.718
54 25 -0.6950 0 0.10526 0.11846 0.824
60 31 -0.7254 0 0.13158 0.10509 0.694
66 54 -0.3543 0 0.09582 0.14670 0.930
72 63 -1.0057 0 0.10661 0.09227 1.030
78 50 -0.5754 0 0.06078 0.11514 1.300
84 26 -0.7838 0 0.15605 0.12888 1.053
90 42 -0.4211 0 0.08401 0.15788 1.164
96 44 -1.1110 0 0.11167 0.14181 1.105
102 30 -0.6161 0 0.10819 0.32536 2.641
108 10 -0.2544 0 0.17645 0.19433 0.621
114 14 -0.0236 0 0.08820 0.19828 0.830
120 16 -1.1636 0 0.06748 0.03704 0.537
126 8 -0.1227 0 0.05333 0.14778 0.891
Dementia
6 430 -2.0833 0 -0.02632 -0.03496 1.590
12 557 -1.6923 0 -0.02288 -0.02028 1.667
18 8 -0.7368 0 0.09211 0.00696 0.447
MCI
24 450 -1.6879 0 0.00000 0.02663 1.735
30 11 -0.5000 0 0.12838 0.14370 0.763
36 355 -1.7341 0 0.02564 0.04423 1.989
48 255 -2.3077 0 0.02564 0.03407 2.708
54 6 -0.3326 0 0.11100 0.18040 0.940
60 122 -1.2147 0 0.03846 0.06697 1.133
66 32 -1.0945 0 -0.01008 0.07285 1.478
72 66 -0.9708 0 0.09419 0.09120 0.878
78 38 -1.1254 0 -0.01251 0.04185 1.596
84 56 -1.0652 0 0.00742 0.03028 1.383
90 45 -1.0945 0 0.02853 0.06999 2.589
96 41 -1.0938 0 -0.10121 -0.00312 1.409
102 36 -0.8739 0 0.05115 -0.04094 0.615
108 33 -0.8617 0 0.00925 0.05883 1.473
114 22 -0.8839 0 0.09562 0.16203 1.016
120 24 -1.3655 0 0.06140 0.04757 1.383
126 10 -1.4744 0 0.16664 0.01657 0.838
132 9 -1.3918 0 -0.27126 -0.27061 0.830
6 120 -1.6923 0 0.02315 -0.01193 1.513
12 128 -1.3799 0 -0.00694 0.00187 2.098
24 41 -1.4309 0 0.05714 0.10646 2.321

SP ECog - Total change from baseline

Month N Min. NA. Median Mean Max.
CN
6 265 -0.8794 0 0.00000 0.00909 0.846
12 262 -1.2051 0 0.00000 0.03856 1.615
24 385 -1.1255 0 0.00000 0.04239 2.000
30 31 -0.3158 0 0.00284 0.04355 1.113
36 57 -1.3300 0 0.05128 0.13448 2.051
42 9 -0.4324 0 0.00000 0.04505 0.237
48 177 -1.0513 0 0.00000 0.06808 1.678
54 24 -0.3183 0 0.07292 0.15518 0.847
60 30 -0.5405 0 0.03975 0.20949 2.538
66 52 -0.5641 0 0.03121 0.13301 1.426
72 61 -0.9939 0 0.05263 0.18249 2.520
78 52 -1.5441 0 0.05263 0.19780 2.947
84 26 -0.6457 0 0.00607 0.27654 2.397
90 41 -0.5641 0 0.09048 0.22968 2.305
96 41 -0.9939 0 0.00000 0.17574 2.474
102 27 -0.1433 0 0.08165 0.33247 2.447
108 11 -0.1053 0 0.26721 0.43691 2.872
114 15 -0.5641 0 0.17949 0.48361 2.735
120 15 -0.4595 0 0.00000 0.04161 0.727
126 8 -0.0294 0 0.41930 0.51514 1.158
Dementia
6 426 -1.4615 0 0.02065 0.05147 1.991
12 548 -2.0388 0 0.05128 0.08728 2.224
18 8 -0.5789 0 -0.00213 -0.01280 0.500
24 449 -1.4103 0 0.11257 0.18615 2.410
MCI
30 11 -0.9211 0 0.27778 0.32481 1.586
36 355 -2.1375 0 0.15385 0.25612 2.513
48 251 -2.1147 0 0.14761 0.27862 2.615
54 6 -0.1005 0 0.42689 0.52356 1.318
60 119 -1.0538 0 0.16552 0.30788 2.401
66 37 -0.6606 0 0.22637 0.40747 1.912
72 64 -1.1026 0 0.13839 0.22995 1.830
78 43 -1.0155 0 0.13158 0.29339 2.250
84 58 -1.3448 0 0.16599 0.43692 2.300
90 46 -0.9946 0 0.14782 0.30064 2.400
96 41 -1.0816 0 0.12233 0.47064 2.299
102 35 -1.2051 0 0.22973 0.29869 2.513
108 36 -0.5886 0 0.08536 0.45693 2.819
114 22 -0.4352 0 0.12517 0.31653 1.556
120 23 -0.2598 0 0.02834 0.20402 1.998
126 9 -0.1988 0 0.50035 0.53188 1.517
132 8 -0.5142 0 -0.02312 0.19815 1.162
6 130 -2.5000 0 0.12557 0.10533 1.333
12 151 -1.4615 0 0.31579 0.34250 1.571
24 54 -0.6494 0 0.45338 0.46613 2.079
30 5 0.5789 0 0.80105 0.82319 1.105

Biomarkers

Volumetrics

UCSF Hippocampus change from baseline

Month N Min. NA. Median Mean Max.
CN
3 182 -815 0 -18.5 -15.7 756.0
6 329 -1940 0 -30.0 -54.4 758.0
12 385 -1965 0 -66.2 -94.5 774.0
24 434 -1435 0 -167.4 -184.7 2590.0
30 22 -638 0 -229.9 -246.6 90.9
36 139 -1117 0 -245.0 -260.2 622.0
48 200 -3084 0 -349.0 -415.1 744.0
54 12 -662 0 -280.2 -291.7 -41.9
60 79 -1269 0 -412.0 -399.5 655.0
66 33 -1160 0 -450.2 -482.0 265.2
72 113 -1820 0 -485.0 -515.2 395.5
78 27 -1327 0 -495.7 -560.1 158.2
84 28 -2842 0 -436.5 -607.8 148.0
90 24 -1598 0 -635.4 -709.0 133.0
96 41 -2052 0 -609.3 -684.8 100.6
102 9 -946 0 -611.6 -564.9 -230.6
108 17 -1842 0 -490.0 -687.7 209.0
120 17 -2142 0 -814.7 -924.8 -172.5
132 17 -1585 0 -788.6 -675.7 532.4
138 6 -1218 0 -733.9 -688.3 -288.9
144 12 -1535 0 -669.2 -660.1 310.6
156 12 -1367 0 -938.1 -917.3 -231.9
Dementia
3 354 -801 0 -34.0 -30.0 885.0
6 600 -1376 0 -77.5 -68.7 733.0
12 641 -969 0 -152.0 -157.9 630.0
18 205 -966 0 -274.0 -259.7 590.0
MCI
24 513 -2772 0 -292.0 -303.7 456.0
30 6 -817 0 -511.2 -515.3 -332.4
36 230 -1482 0 -430.0 -456.8 548.0
48 232 -2626 0 -558.0 -617.2 479.0
60 101 -2185 0 -649.0 -713.7 240.0
66 18 -1243 0 -664.2 -610.4 349.8
72 95 -2525 0 -729.0 -801.2 394.0
78 28 -1912 0 -630.8 -668.2 523.0
84 54 -2063 0 -641.1 -712.0 409.3
90 28 -2431 0 -647.3 -771.1 151.0
96 35 -2848 0 -868.0 -900.3 440.9
102 21 -2029 0 -646.8 -748.8 5.1
108 22 -2928 0 -679.4 -886.3 304.5
114 8 -2025 0 -837.6 -975.8 -371.4
120 14 -1508 0 -954.4 -914.8 -199.0
126 6 -1387 0 -1282.1 -1144.6 -608.2
132 9 -1130 0 -444.1 -609.5 -162.3
144 6 -1923 0 -667.6 -1020.2 -419.6
3 92 -685 0 -36.0 -30.1 927.0
6 191 -1332 0 -136.0 -116.5 1865.0
12 199 -1562 0 -261.0 -267.2 833.0
24 108 -1109 0 -416.0 -435.1 1375.0

UCSF WholeBrain change from baseline

Month N Min. NA. Median Mean Max.
CN
3 201 -72848 0 -2395 -3018 35447
6 381 -106897 0 -4942 -4579 101877
12 431 -78206 0 -7351 -7196 51519
24 469 -88405 0 -13759 -13156 475649
30 22 -32766 0 -12414 -11120 11604
36 171 -85200 0 -20209 -20227 41140
48 216 -183387 0 -28100 -27806 47403
54 13 -67270 0 -33188 -28837 20498
60 101 -145445 0 -40667 -43638 44628
66 41 -82351 0 -38056 -36903 39906
72 137 -149221 0 -47276 -45401 64655
78 30 -83931 0 -39971 -38238 25986
84 34 -113695 0 -16349 -15831 56739
90 31 -123532 0 -50467 -52030 -5026
96 43 -99261 0 -30573 -27419 41586
102 9 -109557 0 -60404 -61424 -8558
108 20 -83236 0 -31314 -32128 24174
114 5 -87489 0 -52857 -46819 12182
120 15 -94523 0 -45608 -43946 12911
132 19 -86393 0 -27712 -32188 14012
138 8 -80558 0 -49714 -39430 31555
144 14 -97927 0 -43671 -44896 11757
150 7 -109584 0 -44531 -29903 43937
156 13 -96677 0 -54220 -47150 36707
162 5 -82452 0 -18982 -28415 1975
Dementia
3 408 -61742 0 -1967 -1456 40771
6 735 -94640 0 -4878 -5163 92397
12 799 -64433 0 -9768 -9923 55512
18 291 -96551 0 -17402 -17710 57514
MCI
24 606 -318527 0 -18034 -19918 59818
30 7 -54042 0 -30132 -32482 -10890
36 295 -143138 0 -28545 -30960 63734
48 248 -160256 0 -39111 -41811 75934
60 117 -189119 0 -60540 -64531 57796
66 22 -87250 0 -46729 -42516 50524
72 125 -228487 0 -58662 -61269 51610
78 29 -131070 0 -50056 -51909 -10480
84 60 -140790 0 -47730 -43797 30939
90 34 -129225 0 -49424 -54381 32702
96 40 -92770 0 -55517 -50207 20738
102 24 -89664 0 -60276 -60631 -18168
108 27 -152216 0 -59304 -62247 10736
114 9 -86467 0 -59096 -55996 9118
120 16 -95178 0 -66478 -53840 4340
126 8 -164250 0 -51270 -57165 20119
132 10 -87434 0 -37822 -41005 -911
138 6 -68077 0 -30374 -35819 -22531
144 6 -116380 0 -41554 -53921 4695
150 6 -70254 0 -35232 -37728 -7701
3 103 -49206 0 -5850 -5798 22851
6 262 -77681 0 -9585 -9763 80065
12 253 -86270 0 -18033 -17425 62386
24 139 -87554 0 -33646 -31828 32486

UCSF Entorhinal change from baseline

Month N Min. NA. Median Mean Max.
CN
3 181 -1224 0 6.0 -51.49 694
6 331 -1561 0 -34.0 -52.06 1535
12 368 -1234 0 -58.5 -59.37 1304
24 400 -1086 0 -81.0 -67.86 1364
30 22 -769 0 -40.0 -82.86 639
36 139 -1113 0 -98.0 -99.55 868
48 178 -1491 0 -142.5 -94.52 1269
54 11 -60 0 316.0 386.82 861
60 76 -1744 0 -143.0 -185.05 1310
66 38 -735 0 202.0 307.89 2169
72 112 -1089 0 -113.5 -116.35 1081
78 27 -780 0 250.0 243.85 1404
84 27 -1218 0 -7.0 -80.70 817
90 28 -1093 0 162.5 139.14 1689
96 39 -1280 0 15.0 -6.85 1213
102 8 -1103 0 262.0 198.38 1547
108 16 -1156 0 -302.5 -205.12 908
114 5 -1620 0 -247.0 -428.80 234
120 14 -973 0 -502.0 -303.93 1087
132 17 -1797 0 119.0 96.41 1384
138 6 -2089 0 -464.0 -519.33 546
144 12 -644 0 2.0 49.25 975
156 12 -1093 0 -105.5 -59.17 1238
Dementia
3 350 -1139 0 -63.0 -36.08 1178
6 585 -1820 0 -49.0 -48.96 1230
12 623 -1856 0 -92.0 -91.81 1461
18 205 -1867 0 -217.0 -197.51 1797
MCI
24 453 -2163 0 -170.0 -179.00 897
30 6 -555 0 -308.0 -346.83 -110
36 212 -2445 0 -280.5 -246.67 853
48 194 -1970 0 -243.5 -320.97 967
60 91 -1421 0 -425.0 -405.59 1647
66 19 -1255 0 -56.0 13.42 1084
72 92 -1897 0 -265.0 -282.03 1218
78 27 -1350 0 33.0 -50.11 1238
84 50 -1655 0 54.5 -38.94 2068
90 28 -1441 0 129.0 -99.64 1003
96 28 -1334 0 155.5 18.50 1186
102 21 -1512 0 197.0 30.14 1237
108 25 -1782 0 230.0 -61.68 1141
114 8 -944 0 -199.5 -51.50 1296
120 13 -2237 0 346.0 218.31 1014
126 5 -1898 0 -748.0 -562.80 1392
132 9 -343 0 157.0 296.00 1060
144 6 -586 0 557.5 485.50 1277
3 75 -809 0 30.0 24.41 632
6 171 -1681 0 -67.0 -27.35 1566
12 172 -1437 0 -160.0 -145.38 1004
24 100 -1224 0 -246.0 -261.47 489