ADNI enrollment summaries using the ADNIMERGE R package

Description

This package vignette demonstrates how to use the ADNIMERGE package to generate simple enrollment and longitudinal summaries and plots with R and knitr.

Report generated from Enrollment.Rmd

Load required R packages and functions

options(digits = 3)
library(knitr)
library(ADNIMERGE)
library(ggplot2)
library(Hmisc)
library(gridExtra)
library(RColorBrewer)
source("https://adni.bitbucket.io/myfunctions.R")
theme_set(theme_bw())
dd <- adnimerge
dd$AGEC <- cut(dd$AGE, breaks = seq(39, 110, by = 10))

label(dd$PTEDUCAT) <- "Education"
label(dd$AGE) <- "Age"
label(dd$AGEC) <- "Age"
label(dd$PTGENDER) <- "Sex"
label(dd$PTETHCAT) <- "Ethnicity"
label(dd$PTRACCAT) <- "Race"
label(dd$PTMARRY) <- "Marital"
label(dd$CDRSB) <- "CDR-SB"
label(dd$ADAS11) <- "ADAS 11"
label(dd$ADAS13) <- "ADAS 13"
label(dd$MMSE) <- "MMSE"

# indicate the bl withdrawals:
BLTDS <- subset(treatdis, VISCODE == "bl" & WDRAWTYPE == "Full")$RID
dd$VISCODE <- with(dd, ifelse(VISCODE == "bl" & RID %in% BLTDS, "blwd", VISCODE))

Demographic Summaries by Diagnosis

Baseline

# Subsetting on RID < 2000 excludes ADNIGO/2 subjects
summary(DX.bl ~ AGE + AGEC + PTGENDER + PTEDUCAT + PTMARRY + PTETHCAT + PTRACCAT + 
    CDRSB + ADAS13 + MMSE, data = dd, subset = VISCODE %in% c("bl", "blwd"), method = "reverse", 
    test = TRUE, overall = TRUE)

Descriptive Statistics by Baseline Dx

N CN (N=518) SMC (N=303) EMCI (N=400) LMCI (N=656) AD (N=398) Combined (N=2275) Test Statistic
Age [Years] 2281
    69.9/73.2/77.7
    66.8/70.2/75.8
    66.0/71.5/76.4
    69.2/74.3/79.3
    70.5/75.3/80.3
    68.2/73.2/78.3
F=21.6 d.f.=4,2266 P<0.001
Age : (39,49] 2281
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
Chi-square=167 d.f.=16 P<0.001
(49,59]
      1%  (   5)
      2%  (   6)
      4%  (  17)
      3%  (  21)
      4%  (  16)
      3%  (  65)
(59,69]
     19%  (  99)
     41%  ( 125)
     36%  ( 142)
     21%  ( 137)
     17%  (  66)
     25%  ( 569)
(69,79]
     61%  ( 317)
     45%  ( 137)
     44%  ( 176)
     49%  ( 321)
     46%  ( 185)
     50%  (1136)
(79,89]
     18%  (  95)
     10%  (  31)
     16%  (  64)
     26%  ( 172)
     31%  ( 124)
     21%  ( 486)
(89,99]
      0%  (   1)
      1%  (   4)
      0%  (   0)
      0%  (   3)
      2%  (   7)
      1%  (  15)
(99,109]
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
Sex : Male 2285
     47%  ( 244)
     38%  ( 116)
     56%  ( 225)
     61%  ( 402)
     56%  ( 224)
     53%  (1211)
Chi-square=55 d.f.=4 P<0.001
Education 2285
       14/16/18
       16/17/18
       14/16/18
       14/16/18
       13/16/18
       14/16/18
F=15.5 d.f.=4,2270 P<0.001
Marital : Divorced 2285
     10%  (  54)
     13%  (  39)
     11%  (  43)
      8%  (  53)
      4%  (  14)
      9%  ( 203)
Chi-square=63.9 d.f.=16 P<0.001
Married
     69%  ( 360)
     72%  ( 217)
     78%  ( 311)
     78%  ( 512)
     84%  ( 336)
     76%  (1736)
Never married
      5%  (  27)
      5%  (  15)
      4%  (  16)
      2%  (  12)
      3%  (  10)
      4%  (  80)
Unknown
      0%  (   1)
      0%  (   1)
      1%  (   4)
      0%  (   2)
      0%  (   0)
      0%  (   8)
Widowed
     15%  (  76)
     10%  (  31)
      6%  (  26)
     12%  (  77)
     10%  (  38)
     11%  ( 248)
Ethnicity : Unknown 2285
      0%  (   2)
      1%  (   2)
      0%  (   2)
      0%  (   3)
      1%  (   3)
      1%  (  12)
Chi-square=6.18 d.f.=8 P=0.627
Not Hisp/Latino
     95%  ( 494)
     95%  ( 289)
     94%  ( 376)
     97%  ( 635)
     96%  ( 381)
     96%  (2175)
Hisp/Latino
      4%  (  22)
      4%  (  12)
      6%  (  22)
      3%  (  18)
      4%  (  14)
      4%  (  88)
Race : Am Indian/Alaskan 2285
      0%  (   2)
      0%  (   0)
      0%  (   2)
      0%  (   1)
      0%  (   0)
      0%  (   5)
Chi-square=53.9 d.f.=24 P<0.001
Asian
      2%  (   9)
      3%  (  10)
      1%  (   5)
      2%  (  12)
      3%  (  10)
      2%  (  46)
Hawaiian/Other PI
      0%  (   0)
      0%  (   0)
      0%  (   1)
      0%  (   1)
      0%  (   0)
      0%  (   2)
Black
      6%  (  32)
      8%  (  23)
      2%  (  10)
      5%  (  30)
      4%  (  17)
      5%  ( 112)
White
     91%  ( 473)
     85%  ( 259)
     92%  ( 370)
     93%  ( 608)
     92%  ( 367)
     91%  (2077)
More than one
      0%  (   2)
      3%  (  10)
      2%  (   8)
      0%  (   3)
      1%  (   4)
      1%  (  27)
Unknown
      0%  (   0)
      0%  (   1)
      1%  (   4)
      0%  (   1)
      0%  (   0)
      0%  (   6)
CDR-SB 2285
    0.00/0.00/0.00
    0.00/0.00/0.00
    0.50/1.00/1.62
    1.00/1.50/2.00
    3.50/4.50/5.00
    0.00/1.00/2.50
F=2902 d.f.=4,2270 P<0.001
ADAS 13 2261
   6.67/ 9.67/12.67
   8.33/11.00/14.33
   9.00/13.67/17.00
  14.67/18.67/23.33
  24.67/29.67/35.00
  10.00/15.00/22.33
F=668 d.f.=4,2249 P<0.001
MMSE 2285
       29/29/30
       29/29/30
       28/29/29
       26/27/29
       21/23/25
       26/28/29
F=601 d.f.=4,2270 P<0.001

Demographic Summaries by Diagnosis

Baseline

# Subsetting on RID > 2000 excludes ADNI1 subjects
summary(DX.bl ~ AGE + AGEC + PTGENDER + PTEDUCAT + PTMARRY + PTETHCAT + PTRACCAT + 
    CDRSB + ADAS13 + MMSE, data = dd, subset = VISCODE == "bl", method = "reverse", 
    test = TRUE, overall = TRUE)

Descriptive Statistics by Baseline Dx

N CN (N=511) SMC (N=300) EMCI (N=389) LMCI (N=644) AD (N=388) Combined (N=2232) Test Statistic
Age [Years] 2238
    69.9/73.2/77.7
    66.8/70.2/75.8
    66.2/71.5/76.4
    69.2/74.3/79.2
    70.4/75.3/80.3
    68.3/73.2/78.3
F=20.7 d.f.=4,2223 P<0.001
Age : (39,49] 2238
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
Chi-square=163 d.f.=16 P<0.001
(49,59]
      1%  (   5)
      2%  (   6)
      4%  (  16)
      3%  (  20)
      4%  (  16)
      3%  (  63)
(59,69]
     19%  (  97)
     41%  ( 124)
     35%  ( 137)
     21%  ( 135)
     16%  (  64)
     25%  ( 557)
(69,79]
     61%  ( 313)
     45%  ( 135)
     45%  ( 173)
     49%  ( 316)
     47%  ( 181)
     50%  (1118)
(79,89]
     18%  (  94)
     10%  (  31)
     16%  (  62)
     26%  ( 168)
     31%  ( 120)
     21%  ( 475)
(89,99]
      0%  (   1)
      1%  (   4)
      0%  (   0)
      0%  (   3)
      2%  (   7)
      1%  (  15)
(99,109]
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
Sex : Male 2242
     47%  ( 242)
     38%  ( 114)
     57%  ( 221)
     61%  ( 396)
     56%  ( 219)
     53%  (1192)
Chi-square=56.3 d.f.=4 P<0.001
Education 2242
    14.0/16.0/18.0
    15.8/17.0/18.0
    14.0/16.0/18.0
    14.0/16.0/18.0
    13.0/16.0/18.0
    14.0/16.0/18.0
F=15.1 d.f.=4,2227 P<0.001
Marital : Divorced 2242
     10%  (  53)
     13%  (  39)
     11%  (  41)
      8%  (  53)
      4%  (  14)
      9%  ( 200)
Chi-square=62.8 d.f.=16 P<0.001
Married
     70%  ( 357)
     72%  ( 216)
     78%  ( 305)
     78%  ( 502)
     84%  ( 327)
     76%  (1707)
Never married
      5%  (  26)
      5%  (  15)
      4%  (  15)
      2%  (  11)
      3%  (  10)
      3%  (  77)
Unknown
      0%  (   1)
      0%  (   1)
      1%  (   4)
      0%  (   2)
      0%  (   0)
      0%  (   8)
Widowed
     14%  (  74)
     10%  (  29)
      6%  (  24)
     12%  (  76)
     10%  (  37)
     11%  ( 240)
Ethnicity : Unknown 2242
      0%  (   2)
      1%  (   2)
      1%  (   2)
      0%  (   3)
      1%  (   3)
      1%  (  12)
Chi-square=6.44 d.f.=8 P=0.598
Not Hisp/Latino
     95%  ( 487)
     95%  ( 286)
     94%  ( 366)
     97%  ( 624)
     96%  ( 372)
     96%  (2135)
Hisp/Latino
      4%  (  22)
      4%  (  12)
      5%  (  21)
      3%  (  17)
      3%  (  13)
      4%  (  85)
Race : Am Indian/Alaskan 2242
      0%  (   2)
      0%  (   0)
      1%  (   2)
      0%  (   1)
      0%  (   0)
      0%  (   5)
Chi-square=54.4 d.f.=24 P<0.001
Asian
      2%  (   9)
      3%  (  10)
      1%  (   5)
      2%  (  12)
      3%  (  10)
      2%  (  46)
Hawaiian/Other PI
      0%  (   0)
      0%  (   0)
      0%  (   1)
      0%  (   1)
      0%  (   0)
      0%  (   2)
Black
      6%  (  32)
      8%  (  23)
      2%  (   9)
      5%  (  29)
      4%  (  17)
      5%  ( 110)
White
     91%  ( 466)
     85%  ( 256)
     93%  ( 361)
     93%  ( 597)
     92%  ( 357)
     91%  (2037)
More than one
      0%  (   2)
      3%  (  10)
      2%  (   7)
      0%  (   3)
      1%  (   4)
      1%  (  26)
Unknown
      0%  (   0)
      0%  (   1)
      1%  (   4)
      0%  (   1)
      0%  (   0)
      0%  (   6)
CDR-SB 2242
     0.0/0.0/0.0
     0.0/0.0/0.0
     0.5/1.0/2.0
     1.0/1.5/2.0
     3.5/4.5/5.0
     0.0/1.0/2.0
F=2875 d.f.=4,2227 P<0.001
ADAS 13 2222
   6.67/ 9.67/12.67
   8.67/11.33/14.33
   9.00/13.84/17.00
  14.67/19.00/23.67
  24.33/29.50/35.00
  10.00/15.00/22.33
F=650 d.f.=4,2210 P<0.001
MMSE 2242
       29/29/30
       29/29/30
       28/29/29
       26/27/29
       21/23/25
       26/28/29
F=583 d.f.=4,2227 P<0.001

Baseline box plots

dd1 <- subset(dd, VISCODE == "bl" & !is.na(DX.bl), c("RID", "DX.bl", "ADAS13", "CDRSB", 
    "MMSE", "EcogPtMem", "EcogSPMem", "EcogPtTotal", "EcogSPTotal"))
ggplot(dd1, aes(DX.bl, ADAS13)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, MMSE)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, CDRSB)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, EcogPtMem)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Self Memory")

ggplot(dd1, aes(DX.bl, EcogSPMem)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Partner Memory")

ggplot(dd1, aes(DX.bl, EcogPtTotal)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Self Total")

ggplot(dd1, aes(DX.bl, EcogSPTotal)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Partner Total")

Baseline summary statistics

cols <- c("ADAS13", "MMSE", "CDRSB", "EcogPtMem", "EcogPtTotal", "EcogSPTotal")
for (cc in cols) {
    dd1$x <- dd1[, cc]
    tab <- with(dd1, Hmisc::summarize(x, by = DX.bl, FUN = summary.default, stat.name = "N"))
    cat("\n### ", label(dd1[, cc]), "\n")
    rownames(tab) <- tab[, 1]
    kable(tab[, -1])
}

###  ADAS 13 

###  MMSE 

###  CDR-SB 

###  Pt ECog - Mem 

###  Pt ECog - Total 

###  SP ECog - Total 

Longitudinal plots


\clearpage
\subsection{ ADAS 13 change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $270$&   $-11.00$&   $-2.00$&   $ 0.000$&   $-0.3850$&   $ 2.00$&   $11.0$&   $ 3.43$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $263$&   $-11.00$&   $-3.00$&   $-0.340$&   $-0.5300$&   $ 2.00$&   $11.0$&   $ 3.73$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $367$&   $-10.00$&   $-2.34$&   $-0.330$&   $-0.3700$&   $ 2.00$&   $13.3$&   $ 3.49$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 44$&   $ -8.00$&   $-2.00$&   $-0.500$&   $-0.2420$&   $ 2.00$&   $11.0$&   $ 3.68$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $161$&   $ -8.00$&   $-2.00$&   $ 1.670$&   $ 1.3600$&   $ 4.00$&   $15.0$&   $ 4.63$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 53$&   $ -1.67$&   $ 2.67$&   $ 4.330$&   $ 5.1500$&   $ 7.00$&   $18.0$&   $ 4.47$\tabularnewline
   ~~72&   $119$&   $ -2.67$&   $ 2.00$&   $ 4.670$&   $ 5.4700$&   $ 7.67$&   $23.7$&   $ 4.65$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 54$&   $ -4.33$&   $ 3.33$&   $ 5.840$&   $ 7.0100$&   $ 8.33$&   $28.3$&   $ 6.32$\tabularnewline
   ~~96&   $ 44$&   $ -5.33$&   $ 2.00$&   $ 5.160$&   $ 5.6100$&   $ 7.83$&   $23.0$&   $ 5.49$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  4$&   $  5.00$&   $ 6.00$&   $ 6.330$&   $ 7.6600$&   $ 8.00$&   $13.0$&   $ 3.61$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $429$&   $-12.00$&   $-3.00$&   $ 0.000$&   $ 0.0583$&   $ 3.00$&   $16.0$&   $ 4.38$\tabularnewline
   ~~12&   $522$&   $-15.00$&   $-3.00$&   $-0.165$&   $ 0.0894$&   $ 3.00$&   $54.0$&   $ 4.99$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $399$&   $-11.00$&   $-2.17$&   $ 0.330$&   $ 1.1900$&   $ 4.00$&   $21.0$&   $ 5.51$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $318$&   $-14.00$&   $-2.00$&   $ 1.000$&   $ 2.0600$&   $ 5.00$&   $49.0$&   $ 7.44$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $252$&   $-12.00$&   $-2.00$&   $ 1.000$&   $ 3.4800$&   $ 6.00$&   $55.0$&   $ 9.57$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $139$&   $ -7.00$&   $ 0.00$&   $ 3.000$&   $ 5.5000$&   $ 8.16$&   $71.0$&   $10.90$\tabularnewline
   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $101$&   $ -5.00$&   $ 2.00$&   $ 4.670$&   $ 5.7600$&   $ 8.00$&   $37.0$&   $ 6.79$\tabularnewline
   ~~84&   $ 88$&   $ -3.33$&   $ 2.67$&   $ 5.340$&   $ 6.8900$&   $ 9.42$&   $24.7$&   $ 6.24$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 66$&   $ -5.00$&   $ 3.33$&   $ 6.160$&   $ 8.3300$&   $11.60$&   $38.7$&   $ 7.92$\tabularnewline
   ~~108&   $ 23$&   $ -5.67$&   $ 2.66$&   $ 5.330$&   $ 6.5700$&   $ 9.00$&   $25.0$&   $ 6.90$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  4$&   $  1.33$&   $ 2.83$&   $ 8.330$&   $10.7000$&   $16.20$&   $25.0$&   $10.90$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $127$&   $-12.00$&   $-1.50$&   $ 2.000$&   $ 2.3800$&   $ 6.50$&   $23.0$&   $ 5.62$\tabularnewline
   ~~12&   $131$&   $-13.00$&   $ 0.50$&   $ 3.670$&   $ 4.6600$&   $ 8.00$&   $27.0$&   $ 6.32$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $ 39$&   $ -5.00$&   $ 2.66$&   $ 7.000$&   $ 8.6700$&   $13.00$&   $36.0$&   $ 9.13$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $  1$&   $  8.00$&   $ 8.00$&   $ 8.000$&   $ 8.0000$&   $ 8.00$&   $ 8.0$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  2$&   $  6.33$&   $ 7.41$&   $ 8.500$&   $ 8.5000$&   $ 9.59$&   $10.7$&   $ 3.07$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $  1$&   $ 10.00$&   $10.00$&   $10.000$&   $10.0000$&   $10.00$&   $10.0$&   $$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ MMSE change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $274$&   $ -4$&   $-1.00$&   $ 0.0$&   $-0.0547$&   $ 1.00$&   $ 4$&   $1.40$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $266$&   $ -8$&   $-1.00$&   $ 0.0$&   $-0.2110$&   $ 1.00$&   $ 4$&   $1.59$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $375$&   $ -5$&   $-1.00$&   $ 0.0$&   $-0.1090$&   $ 1.00$&   $ 4$&   $1.43$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 47$&   $ -5$&   $-1.00$&   $ 0.0$&   $-0.3830$&   $ 1.00$&   $ 4$&   $1.80$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $161$&   $ -7$&   $-1.00$&   $ 0.0$&   $-0.2730$&   $ 1.00$&   $ 4$&   $1.69$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 53$&   $-10$&   $-1.00$&   $ 0.0$&   $-0.1890$&   $ 0.00$&   $ 4$&   $1.97$\tabularnewline
   ~~72&   $118$&   $ -8$&   $-1.00$&   $ 0.0$&   $-0.3310$&   $ 1.00$&   $ 4$&   $1.91$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 53$&   $ -7$&   $-2.00$&   $ 0.0$&   $-1.0200$&   $ 0.00$&   $ 3$&   $1.95$\tabularnewline
   ~~96&   $ 45$&   $ -4$&   $-2.00$&   $ 0.0$&   $-0.3780$&   $ 1.00$&   $ 4$&   $1.68$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  4$&   $ -3$&   $-2.25$&   $-1.0$&   $-1.0000$&   $ 0.25$&   $ 1$&   $1.83$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $430$&   $-10$&   $-2.00$&   $ 0.0$&   $-0.4490$&   $ 1.00$&   $ 5$&   $1.88$\tabularnewline
   ~~12&   $526$&   $-11$&   $-2.00$&   $ 0.0$&   $-0.5250$&   $ 1.00$&   $ 6$&   $2.09$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $405$&   $-11$&   $-2.00$&   $ 0.0$&   $-0.9060$&   $ 1.00$&   $ 6$&   $2.44$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $319$&   $-23$&   $-2.00$&   $-1.0$&   $-1.2400$&   $ 1.00$&   $ 6$&   $3.31$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $256$&   $-20$&   $-3.00$&   $-1.0$&   $-1.6000$&   $ 1.00$&   $ 5$&   $3.82$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $143$&   $-30$&   $-3.00$&   $-1.0$&   $-1.9900$&   $ 0.00$&   $ 4$&   $4.64$\tabularnewline
   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $105$&   $-24$&   $-2.00$&   $ 0.0$&   $-1.5300$&   $ 1.00$&   $ 5$&   $4.23$\tabularnewline
   ~~84&   $ 93$&   $-20$&   $-3.00$&   $-1.0$&   $-1.7300$&   $ 1.00$&   $ 6$&   $4.30$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 67$&   $-12$&   $-2.50$&   $-1.0$&   $-1.6900$&   $ 1.00$&   $ 5$&   $3.76$\tabularnewline
   ~~108&   $ 24$&   $ -5$&   $-2.00$&   $-0.5$&   $-0.7920$&   $ 1.00$&   $ 2$&   $1.93$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  4$&   $ -5$&   $-2.75$&   $-1.5$&   $-2.0000$&   $-0.75$&   $ 0$&   $2.16$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $131$&   $-16$&   $-3.00$&   $-1.0$&   $-1.1800$&   $ 1.00$&   $ 8$&   $3.07$\tabularnewline
   ~~12&   $136$&   $-19$&   $-5.00$&   $-2.0$&   $-2.5100$&   $ 0.00$&   $ 5$&   $4.12$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $ 41$&   $-15$&   $-6.00$&   $-4.0$&   $-4.2400$&   $-2.00$&   $ 3$&   $3.85$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $  1$&   $ -2$&   $-2.00$&   $-2.0$&   $-2.0000$&   $-2.00$&   $-2$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  2$&   $ -4$&   $-3.00$&   $-2.0$&   $-2.0000$&   $-1.00$&   $ 0$&   $2.83$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $  2$&   $ -5$&   $-4.50$&   $-4.0$&   $-4.0000$&   $-3.50$&   $-3$&   $1.41$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ CDR-SB change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.0$&   $ 0.00$&   $ 0.0$&   $ 0.0879$&   $ 0.00$&   $ 2.5$&   $0.348$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $264$&   $-1.0$&   $ 0.00$&   $ 0.0$&   $ 0.1270$&   $ 0.00$&   $ 4.0$&   $0.493$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $395$&   $-1.0$&   $ 0.00$&   $ 0.0$&   $ 0.1520$&   $ 0.00$&   $ 5.0$&   $0.563$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 44$&   $-0.5$&   $ 0.00$&   $ 0.0$&   $ 0.5340$&   $ 0.50$&   $ 5.0$&   $1.200$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $156$&   $-0.5$&   $ 0.00$&   $ 0.0$&   $ 0.2020$&   $ 0.00$&   $ 5.0$&   $0.686$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 56$&   $-0.5$&   $ 0.00$&   $ 0.0$&   $ 0.5540$&   $ 0.50$&   $11.0$&   $1.710$\tabularnewline
   ~~72&   $123$&   $-0.5$&   $ 0.00$&   $ 0.0$&   $ 0.4270$&   $ 0.25$&   $10.0$&   $1.240$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 61$&   $-0.5$&   $ 0.00$&   $ 0.0$&   $ 0.8440$&   $ 1.00$&   $12.0$&   $1.990$\tabularnewline
   ~~96&   $ 47$&   $-0.5$&   $ 0.00$&   $ 0.0$&   $ 0.7340$&   $ 0.50$&   $15.5$&   $2.370$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  5$&   $ 0.0$&   $ 0.00$&   $ 0.5$&   $ 0.5000$&   $ 1.00$&   $ 1.0$&   $0.500$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $426$&   $-3.5$&   $-0.50$&   $ 0.0$&   $ 0.1310$&   $ 0.50$&   $ 3.0$&   $0.807$\tabularnewline
   ~~12&   $524$&   $-3.0$&   $-0.50$&   $ 0.0$&   $ 0.1980$&   $ 0.50$&   $ 5.5$&   $1.030$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $417$&   $-3.0$&   $-0.50$&   $ 0.0$&   $ 0.5960$&   $ 1.00$&   $11.5$&   $1.650$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $329$&   $-3.5$&   $-0.50$&   $ 0.0$&   $ 0.9010$&   $ 1.50$&   $12.5$&   $2.370$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $257$&   $-3.5$&   $-0.50$&   $ 0.0$&   $ 1.1200$&   $ 2.00$&   $16.0$&   $2.910$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $141$&   $-3.0$&   $-0.50$&   $ 0.0$&   $ 0.9260$&   $ 1.50$&   $14.5$&   $2.650$\tabularnewline
   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $109$&   $-3.0$&   $-0.50$&   $ 0.0$&   $ 1.2200$&   $ 1.50$&   $15.5$&   $3.430$\tabularnewline
   ~~84&   $ 95$&   $-3.5$&   $-0.50$&   $ 0.0$&   $ 1.3400$&   $ 1.50$&   $15.0$&   $3.410$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 74$&   $-3.5$&   $-0.50$&   $ 0.0$&   $ 1.4400$&   $ 1.50$&   $14.0$&   $3.620$\tabularnewline
   ~~108&   $ 31$&   $-2.5$&   $-0.75$&   $ 0.0$&   $ 1.2700$&   $ 1.50$&   $16.5$&   $3.840$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  4$&   $-1.5$&   $-0.75$&   $-0.5$&   $-0.2500$&   $ 0.00$&   $ 1.5$&   $1.260$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $131$&   $-2.5$&   $ 0.00$&   $ 0.5$&   $ 0.8130$&   $ 1.50$&   $ 9.0$&   $1.540$\tabularnewline
   ~~12&   $144$&   $-2.0$&   $ 0.00$&   $ 1.0$&   $ 1.9000$&   $ 2.50$&   $11.5$&   $2.490$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $ 44$&   $-1.0$&   $ 1.00$&   $ 2.5$&   $ 3.2200$&   $ 5.00$&   $11.5$&   $2.870$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $  1$&   $ 2.0$&   $ 2.00$&   $ 2.0$&   $ 2.0000$&   $ 2.00$&   $ 2.0$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  1$&   $ 3.0$&   $ 3.00$&   $ 3.0$&   $ 3.0000$&   $ 3.00$&   $ 3.0$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  4$&   $ 2.0$&   $ 4.25$&   $ 8.0$&   $ 7.3800$&   $11.10$&   $11.5$&   $4.640$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $  4$&   $ 7.0$&   $ 8.12$&   $10.0$&   $10.4000$&   $12.20$&   $14.5$&   $3.330$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ Pt ECog - Mem change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.500$&   $-0.250$&   $ 0.0000$&   $ 0.0303$&   $ 0.250$&   $ 1.6200$&   $0.431$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $267$&   $-1.380$&   $-0.250$&   $ 0.0000$&   $ 0.0217$&   $ 0.250$&   $ 1.6200$&   $0.426$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $406$&   $-2.000$&   $-0.250$&   $ 0.0000$&   $ 0.0156$&   $ 0.250$&   $ 1.7500$&   $0.444$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 46$&   $-0.589$&   $-0.250$&   $-0.0625$&   $-0.0400$&   $ 0.125$&   $ 0.7500$&   $0.307$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $163$&   $-1.380$&   $-0.250$&   $ 0.0000$&   $ 0.0563$&   $ 0.375$&   $ 2.1200$&   $0.495$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 57$&   $-1.430$&   $ 0.000$&   $ 0.1250$&   $ 0.1460$&   $ 0.375$&   $ 1.3800$&   $0.494$\tabularnewline
   ~~72&   $122$&   $-1.320$&   $-0.125$&   $ 0.1250$&   $ 0.1690$&   $ 0.500$&   $ 1.6200$&   $0.539$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 62$&   $-1.500$&   $-0.125$&   $ 0.1250$&   $ 0.1920$&   $ 0.500$&   $ 1.8200$&   $0.611$\tabularnewline
   ~~96&   $ 50$&   $-1.120$&   $-0.125$&   $ 0.0625$&   $ 0.2010$&   $ 0.500$&   $ 2.2500$&   $0.609$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  5$&   $-0.500$&   $ 0.000$&   $ 0.2500$&   $ 0.1250$&   $ 0.375$&   $ 0.5000$&   $0.395$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $428$&   $-2.120$&   $-0.375$&   $-0.1250$&   $-0.1040$&   $ 0.250$&   $ 1.6200$&   $0.539$\tabularnewline
   ~~12&   $528$&   $-2.250$&   $-0.375$&   $ 0.0000$&   $-0.0601$&   $ 0.250$&   $ 1.6200$&   $0.600$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $415$&   $-2.880$&   $-0.375$&   $ 0.0000$&   $-0.0204$&   $ 0.375$&   $ 2.5000$&   $0.648$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $322$&   $-2.380$&   $-0.375$&   $-0.0804$&   $-0.0418$&   $ 0.375$&   $ 2.5000$&   $0.633$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $250$&   $-2.500$&   $-0.500$&   $-0.1250$&   $-0.0975$&   $ 0.312$&   $ 2.3600$&   $0.725$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $141$&   $-1.500$&   $-0.375$&   $ 0.0000$&   $ 0.0201$&   $ 0.500$&   $ 1.7500$&   $0.596$\tabularnewline
   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $103$&   $-2.120$&   $-0.375$&   $ 0.0000$&   $ 0.0223$&   $ 0.500$&   $ 1.7500$&   $0.742$\tabularnewline
   ~~84&   $ 95$&   $-2.380$&   $-0.375$&   $-0.1250$&   $-0.0728$&   $ 0.250$&   $ 2.0000$&   $0.658$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 73$&   $-2.500$&   $-0.500$&   $-0.2500$&   $-0.1830$&   $ 0.250$&   $ 2.2100$&   $0.719$\tabularnewline
   ~~108&   $ 31$&   $-2.250$&   $-0.500$&   $-0.1250$&   $-0.2110$&   $ 0.125$&   $ 1.3800$&   $0.730$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  4$&   $-0.500$&   $-0.312$&   $-0.0625$&   $ 0.2500$&   $ 0.500$&   $ 1.6200$&   $0.952$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $124$&   $-1.880$&   $-0.406$&   $ 0.0000$&   $-0.0592$&   $ 0.375$&   $ 1.7500$&   $0.725$\tabularnewline
   ~~12&   $123$&   $-2.000$&   $-0.411$&   $ 0.0000$&   $-0.1310$&   $ 0.375$&   $ 2.0000$&   $0.741$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $ 32$&   $-1.750$&   $-0.500$&   $-0.1880$&   $-0.0954$&   $ 0.277$&   $ 2.1200$&   $0.739$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $  1$&   $-0.500$&   $-0.500$&   $-0.5000$&   $-0.5000$&   $-0.500$&   $-0.5000$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  2$&   $-0.875$&   $-0.665$&   $-0.4550$&   $-0.4550$&   $-0.246$&   $-0.0357$&   $0.593$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $  1$&   $-0.875$&   $-0.875$&   $-0.8750$&   $-0.8750$&   $-0.875$&   $-0.8750$&   $$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ SP ECog - Mem change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $263$&   $-1.380$&   $-0.1250$&   $ 0.000$&   $ 0.01720$&   $0.125$&   $1.620$&   $0.361$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $261$&   $-1.500$&   $-0.1250$&   $ 0.000$&   $ 0.04330$&   $0.250$&   $2.120$&   $0.408$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $386$&   $-1.500$&   $-0.1250$&   $ 0.000$&   $ 0.04600$&   $0.250$&   $2.120$&   $0.411$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 43$&   $-1.380$&   $-0.1250$&   $ 0.125$&   $ 0.17100$&   $0.338$&   $2.120$&   $0.611$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $155$&   $-1.250$&   $-0.1550$&   $ 0.000$&   $ 0.11400$&   $0.250$&   $2.120$&   $0.490$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 54$&   $-0.750$&   $-0.1250$&   $ 0.000$&   $ 0.14100$&   $0.250$&   $2.460$&   $0.568$\tabularnewline
   ~~72&   $122$&   $-1.500$&   $-0.1250$&   $ 0.000$&   $ 0.20600$&   $0.469$&   $2.250$&   $0.623$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 61$&   $-2.380$&   $-0.1250$&   $ 0.125$&   $ 0.33400$&   $0.625$&   $2.750$&   $0.855$\tabularnewline
   ~~96&   $ 48$&   $-1.380$&   $-0.1250$&   $ 0.000$&   $ 0.23700$&   $0.500$&   $3.000$&   $0.690$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  5$&   $-0.125$&   $ 0.1250$&   $ 0.375$&   $ 0.42500$&   $0.625$&   $1.120$&   $0.481$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $424$&   $-1.880$&   $-0.2500$&   $ 0.000$&   $ 0.00345$&   $0.375$&   $2.120$&   $0.561$\tabularnewline
   ~~12&   $521$&   $-2.750$&   $-0.2500$&   $ 0.000$&   $ 0.01460$&   $0.286$&   $2.250$&   $0.586$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $416$&   $-1.880$&   $-0.2500$&   $ 0.000$&   $ 0.10800$&   $0.500$&   $2.120$&   $0.656$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $321$&   $-2.250$&   $-0.2500$&   $ 0.125$&   $ 0.15500$&   $0.500$&   $2.140$&   $0.706$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $245$&   $-1.750$&   $-0.2500$&   $ 0.125$&   $ 0.22500$&   $0.500$&   $2.880$&   $0.710$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $137$&   $-1.620$&   $-0.1790$&   $ 0.125$&   $ 0.27000$&   $0.625$&   $2.500$&   $0.783$\tabularnewline
   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $109$&   $-1.620$&   $-0.2500$&   $ 0.125$&   $ 0.20200$&   $0.625$&   $2.290$&   $0.697$\tabularnewline
   ~~84&   $ 98$&   $-1.250$&   $-0.2630$&   $ 0.125$&   $ 0.25900$&   $0.750$&   $2.500$&   $0.823$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 73$&   $-2.000$&   $-0.1250$&   $ 0.250$&   $ 0.26300$&   $0.625$&   $2.380$&   $0.778$\tabularnewline
   ~~108&   $ 30$&   $-0.750$&   $-0.2500$&   $ 0.000$&   $ 0.23700$&   $0.594$&   $2.500$&   $0.747$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  4$&   $-0.857$&   $-0.5890$&   $-0.250$&   $-0.12500$&   $0.214$&   $0.857$&   $0.743$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $130$&   $-2.750$&   $-0.2500$&   $ 0.000$&   $ 0.04210$&   $0.479$&   $1.620$&   $0.616$\tabularnewline
   ~~12&   $142$&   $-1.620$&   $ 0.0000$&   $ 0.125$&   $ 0.21300$&   $0.500$&   $2.120$&   $0.503$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $ 43$&   $-1.540$&   $-0.0625$&   $ 0.000$&   $ 0.14500$&   $0.375$&   $1.500$&   $0.572$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $  1$&   $ 1.250$&   $ 1.2500$&   $ 1.250$&   $ 1.25000$&   $1.250$&   $1.250$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  1$&   $ 0.000$&   $ 0.0000$&   $ 0.000$&   $ 0.00000$&   $0.000$&   $0.000$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  4$&   $ 0.000$&   $ 0.0938$&   $ 0.625$&   $ 0.84400$&   $1.380$&   $2.120$&   $0.992$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $  4$&   $ 0.000$&   $ 0.8440$&   $ 1.470$&   $ 1.27000$&   $1.900$&   $2.120$&   $0.943$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ Pt ECog - Total change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.140$&   $-0.103000$&   $ 0.0000$&   $ 0.01780$&   $ 0.1280$&   $ 0.8210$&   $0.253$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $267$&   $-0.751$&   $-0.103000$&   $ 0.0000$&   $ 0.02620$&   $ 0.1280$&   $ 1.4600$&   $0.248$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $406$&   $-1.340$&   $-0.105000$&   $ 0.0000$&   $ 0.01240$&   $ 0.1320$&   $ 1.1800$&   $0.296$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 46$&   $-0.526$&   $-0.103000$&   $-0.0256$&   $ 0.00225$&   $ 0.1030$&   $ 0.7440$&   $0.222$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $164$&   $-0.985$&   $-0.107000$&   $ 0.0418$&   $ 0.04310$&   $ 0.1670$&   $ 1.7200$&   $0.304$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 57$&   $-0.725$&   $-0.046600$&   $ 0.1330$&   $ 0.11200$&   $ 0.2210$&   $ 0.7270$&   $0.314$\tabularnewline
   ~~72&   $122$&   $-1.010$&   $-0.022900$&   $ 0.1060$&   $ 0.13600$&   $ 0.2640$&   $ 1.3000$&   $0.329$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 62$&   $-0.784$&   $-0.050200$&   $ 0.0823$&   $ 0.13400$&   $ 0.3070$&   $ 1.1600$&   $0.360$\tabularnewline
   ~~96&   $ 50$&   $-1.110$&   $ 0.000675$&   $ 0.0857$&   $ 0.18400$&   $ 0.2200$&   $ 2.6400$&   $0.522$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  5$&   $-0.147$&   $ 0.076900$&   $ 0.1310$&   $ 0.12800$&   $ 0.1380$&   $ 0.4420$&   $0.211$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $430$&   $-2.080$&   $-0.219000$&   $-0.0263$&   $-0.03500$&   $ 0.1500$&   $ 1.5900$&   $0.376$\tabularnewline
   ~~12&   $531$&   $-1.690$&   $-0.231000$&   $ 0.0000$&   $-0.01980$&   $ 0.1860$&   $ 1.6700$&   $0.395$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $416$&   $-1.690$&   $-0.205000$&   $ 0.0000$&   $ 0.02700$&   $ 0.2310$&   $ 1.7400$&   $0.442$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $318$&   $-1.730$&   $-0.205000$&   $ 0.0256$&   $ 0.04460$&   $ 0.3060$&   $ 1.9900$&   $0.454$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $249$&   $-2.310$&   $-0.247000$&   $ 0.0256$&   $ 0.03160$&   $ 0.3080$&   $ 2.7100$&   $0.529$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $139$&   $-1.210$&   $-0.141000$&   $ 0.0513$&   $ 0.07250$&   $ 0.3260$&   $ 1.1300$&   $0.438$\tabularnewline
   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $103$&   $-1.130$&   $-0.165000$&   $ 0.0540$&   $ 0.09530$&   $ 0.3850$&   $ 1.4800$&   $0.467$\tabularnewline
   ~~84&   $ 95$&   $-1.090$&   $-0.200000$&   $ 0.0054$&   $ 0.01710$&   $ 0.2040$&   $ 1.6000$&   $0.476$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 73$&   $-1.090$&   $-0.251000$&   $ 0.0027$&   $ 0.01890$&   $ 0.1730$&   $ 2.5900$&   $0.507$\tabularnewline
   ~~108&   $ 31$&   $-0.862$&   $-0.387000$&   $-0.0702$&   $-0.10100$&   $ 0.1310$&   $ 0.7770$&   $0.409$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  4$&   $-0.395$&   $-0.100000$&   $ 0.0165$&   $ 0.01460$&   $ 0.1310$&   $ 0.4200$&   $0.333$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $120$&   $-1.690$&   $-0.298000$&   $ 0.0232$&   $-0.01190$&   $ 0.2840$&   $ 1.5100$&   $0.554$\tabularnewline
   ~~12&   $120$&   $-1.380$&   $-0.350000$&   $-0.0106$&   $-0.00239$&   $ 0.2910$&   $ 2.1000$&   $0.557$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $ 32$&   $-1.430$&   $-0.145000$&   $ 0.0779$&   $ 0.12300$&   $ 0.4270$&   $ 2.3200$&   $0.643$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $  1$&   $ 0.553$&   $ 0.553000$&   $ 0.5530$&   $ 0.55300$&   $ 0.5530$&   $ 0.5530$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  2$&   $-0.543$&   $-0.394000$&   $-0.2450$&   $-0.24500$&   $-0.0957$&   $ 0.0535$&   $0.422$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $  1$&   $-0.191$&   $-0.191000$&   $-0.1910$&   $-0.19100$&   $-0.1910$&   $-0.1910$&   $$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ SP ECog - Total change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $265$&   $-0.8790$&   $-0.0513$&   $ 0.0000$&   $ 0.00909$&   $0.0769$&   $0.846$&   $0.193$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $261$&   $-1.2100$&   $-0.0365$&   $ 0.0000$&   $ 0.04000$&   $0.0980$&   $1.620$&   $0.258$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $386$&   $-1.1300$&   $-0.0526$&   $ 0.0000$&   $ 0.03870$&   $0.1000$&   $2.000$&   $0.271$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 43$&   $-1.3300$&   $ 0.0000$&   $ 0.0513$&   $ 0.14100$&   $0.2400$&   $2.050$&   $0.483$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $156$&   $-1.0500$&   $-0.0516$&   $ 0.0000$&   $ 0.08570$&   $0.1290$&   $1.680$&   $0.341$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 54$&   $-0.5400$&   $-0.0447$&   $ 0.0395$&   $ 0.16500$&   $0.2110$&   $2.540$&   $0.509$\tabularnewline
   ~~72&   $121$&   $-0.9940$&   $-0.0513$&   $ 0.0526$&   $ 0.16700$&   $0.2660$&   $2.520$&   $0.464$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 61$&   $-1.5400$&   $ 0.0000$&   $ 0.1050$&   $ 0.28800$&   $0.2910$&   $2.950$&   $0.729$\tabularnewline
   ~~96&   $ 48$&   $-0.9940$&   $-0.0508$&   $ 0.0135$&   $ 0.10800$&   $0.1590$&   $2.470$&   $0.477$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  5$&   $-0.0301$&   $ 0.1580$&   $ 0.2670$&   $ 0.24200$&   $0.3440$&   $0.472$&   $0.190$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $426$&   $-1.4600$&   $-0.1670$&   $ 0.0206$&   $ 0.05150$&   $0.2540$&   $1.990$&   $0.411$\tabularnewline
   ~~12&   $521$&   $-2.0400$&   $-0.1280$&   $ 0.0513$&   $ 0.08430$&   $0.2820$&   $2.090$&   $0.460$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $417$&   $-1.4100$&   $-0.1100$&   $ 0.1130$&   $ 0.19000$&   $0.4050$&   $2.410$&   $0.536$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $320$&   $-2.1400$&   $-0.0995$&   $ 0.1440$&   $ 0.25500$&   $0.4890$&   $2.510$&   $0.616$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $245$&   $-2.1100$&   $-0.1030$&   $ 0.1540$&   $ 0.28400$&   $0.5710$&   $2.620$&   $0.648$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $137$&   $-1.0500$&   $-0.1030$&   $ 0.1660$&   $ 0.32500$&   $0.6910$&   $2.400$&   $0.676$\tabularnewline
   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $109$&   $-1.1000$&   $-0.1010$&   $ 0.1520$&   $ 0.26500$&   $0.5200$&   $2.250$&   $0.622$\tabularnewline
   ~~84&   $ 98$&   $-1.3400$&   $-0.0979$&   $ 0.1580$&   $ 0.37600$&   $0.7420$&   $2.400$&   $0.781$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 73$&   $-1.2100$&   $-0.0486$&   $ 0.1310$&   $ 0.40100$&   $0.5790$&   $2.510$&   $0.797$\tabularnewline
   ~~108&   $ 30$&   $-0.5890$&   $-0.1090$&   $ 0.0854$&   $ 0.35300$&   $0.8190$&   $2.820$&   $0.718$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  4$&   $-0.4090$&   $-0.2650$&   $-0.1090$&   $-0.07760$&   $0.0790$&   $0.316$&   $0.311$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $130$&   $-2.5000$&   $-0.1470$&   $ 0.1260$&   $ 0.10500$&   $0.4100$&   $1.330$&   $0.524$\tabularnewline
   ~~12&   $143$&   $-1.4600$&   $ 0.1060$&   $ 0.3160$&   $ 0.34000$&   $0.5880$&   $1.570$&   $0.457$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~24&   $ 43$&   $-0.4740$&   $ 0.0578$&   $ 0.3850$&   $ 0.41900$&   $0.7740$&   $1.890$&   $0.510$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~36&   $  1$&   $ 1.1100$&   $ 1.1100$&   $ 1.1100$&   $ 1.11000$&   $1.1100$&   $1.110$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  1$&   $ 0.7180$&   $ 0.7180$&   $ 0.7180$&   $ 0.71800$&   $0.7180$&   $0.718$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  4$&   $-0.2410$&   $ 0.4780$&   $ 0.7580$&   $ 0.97900$&   $1.2600$&   $2.640$&   $1.200$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $  4$&   $ 0.6750$&   $ 1.0100$&   $ 1.2000$&   $ 1.43000$&   $1.6200$&   $2.660$&   $0.858$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

R Session Information

{r results = "markup" print(sessionInfo(), locale=FALSE)