ADNI Enrollment

ATRI Biostatistics

ADNI enrollment summaries using the ADNIMERGE R package

Description

This package vignette demonstrates how to use the ADNIMERGE package to generate simple enrollment and longitudinal summaries and plots with R and knitr.

Report generated from Enrollment.Rmd

Load required R packages and functions

options(digits = 3)
library(knitr)
library(ADNIMERGE)
library(ggplot2)
library(Hmisc)
library(gridExtra)
library(RColorBrewer)
library(tidyverse)
library(kableExtra)
source("https://adni.bitbucket.io/myfunctions.R")
theme_set(theme_bw())
dxpal <- c("#2b8cbe", "#74a9cf", "#fdcc8a", "#fc8d59", "#e34a33")
scale_colour_discrete <- function(...) scale_colour_manual(..., values = dxpal)
scale_fill_discrete <- function(...) scale_fill_manual(..., values = dxpal)

Demographic Summaries by Diagnosis

Baseline

Demographic Summaries by Diagnosis

Baseline

CN (N=534) SMC (N=348) EMCI (N=410) LMCI (N=675) AD (N=401) Total (N=2368) p value
Age < 0.0011
   N-Miss 1 0 1 2 0 4
   Mean (SD) 73.321 (6.368) 70.511 (6.790) 71.278 (7.427) 73.775 (7.451) 74.701 (7.925) 72.917 (7.345)
   Range 55.100 - 89.600 50.400 - 90.300 55.000 - 89.100 55.000 - 91.400 55.100 - 90.900 50.400 - 91.400
Age
   N-Miss 1 0 1 2 0 4
   (39,49] 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
   (49,59] 11 (2.1%) 17 (4.9%) 19 (4.6%) 20 (3.0%) 17 (4.2%) 84 (3.6%)
   (59,69] 106 (19.9%) 149 (42.8%) 144 (35.2%) 144 (21.4%) 67 (16.7%) 610 (25.8%)
   (69,79] 321 (60.2%) 145 (41.7%) 180 (44.0%) 336 (49.9%) 188 (46.9%) 1170 (49.5%)
   (79,89] 94 (17.6%) 33 (9.5%) 65 (15.9%) 169 (25.1%) 122 (30.4%) 483 (20.4%)
   (89,99] 1 (0.2%) 4 (1.1%) 1 (0.2%) 4 (0.6%) 7 (1.7%) 17 (0.7%)
   (99,109] 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
Sex < 0.0012
   Female 282 (52.8%) 217 (62.4%) 186 (45.4%) 261 (38.7%) 175 (43.6%) 1121 (47.3%)
   Male 252 (47.2%) 131 (37.6%) 224 (54.6%) 414 (61.3%) 226 (56.4%) 1247 (52.7%)
Education < 0.0011
   Mean (SD) 16.412 (2.613) 16.693 (2.340) 16.020 (2.642) 15.978 (2.831) 15.212 (2.905) 16.058 (2.732)
   Range 6.000 - 20.000 8.000 - 20.000 10.000 - 20.000 4.000 - 20.000 4.000 - 20.000 4.000 - 20.000
Marital < 0.0012
   N-Miss 0 0 1 0 0 1
   Divorced 56 (10.5%) 47 (13.5%) 45 (11.0%) 59 (8.7%) 14 (3.5%) 221 (9.3%)
   Married 367 (68.7%) 243 (69.8%) 315 (77.0%) 523 (77.5%) 338 (84.3%) 1786 (75.5%)
   Never married 32 (6.0%) 20 (5.7%) 17 (4.2%) 13 (1.9%) 11 (2.7%) 93 (3.9%)
   Unknown 1 (0.2%) 2 (0.6%) 4 (1.0%) 2 (0.3%) 0 (0.0%) 9 (0.4%)
   Widowed 78 (14.6%) 36 (10.3%) 28 (6.8%) 78 (11.6%) 38 (9.5%) 258 (10.9%)
Ethnicity 0.1152
   Unknown 2 (0.4%) 2 (0.6%) 2 (0.5%) 3 (0.4%) 3 (0.7%) 12 (0.5%)
   Not Hisp/Latino 506 (94.8%) 319 (91.7%) 386 (94.1%) 650 (96.3%) 384 (95.8%) 2245 (94.8%)
   Hisp/Latino 26 (4.9%) 27 (7.8%) 22 (5.4%) 22 (3.3%) 14 (3.5%) 111 (4.7%)
Race < 0.0012
   Am Indian/Alaskan 2 (0.4%) 0 (0.0%) 2 (0.5%) 1 (0.1%) 0 (0.0%) 5 (0.2%)
   Asian 13 (2.4%) 16 (4.6%) 7 (1.7%) 12 (1.8%) 10 (2.5%) 58 (2.4%)
   Hawaiian/Other PI 0 (0.0%) 0 (0.0%) 1 (0.2%) 1 (0.1%) 0 (0.0%) 2 (0.1%)
   Black 47 (8.8%) 50 (14.4%) 16 (3.9%) 38 (5.6%) 22 (5.5%) 173 (7.3%)
   White 469 (87.8%) 268 (77.0%) 373 (91.0%) 616 (91.3%) 365 (91.0%) 2091 (88.3%)
   More than one 2 (0.4%) 11 (3.2%) 7 (1.7%) 4 (0.6%) 4 (1.0%) 28 (1.2%)
   Unknown 1 (0.2%) 3 (0.9%) 4 (1.0%) 3 (0.4%) 0 (0.0%) 11 (0.5%)
Amyloid Status < 0.0012
   N-Miss 126 37 14 222 94 493
   Negative 120 (29.4%) 145 (46.6%) 71 (17.9%) 67 (14.8%) 17 (5.5%) 420 (22.4%)
   Positive 288 (70.6%) 166 (53.4%) 325 (82.1%) 386 (85.2%) 290 (94.5%) 1455 (77.6%)
CDR-SB < 0.0011
   Mean (SD) 0.031 (0.124) 0.052 (0.157) 1.318 (0.867) 1.635 (0.947) 4.448 (1.688) 1.462 (1.775)
   Range 0.000 - 1.000 0.000 - 1.000 0.000 - 6.000 0.000 - 5.500 1.000 - 10.000 0.000 - 10.000
ADAS 13 < 0.0011
   N-Miss 0 4 3 3 8 18
   Mean (SD) 8.994 (4.421) 8.628 (4.283) 12.862 (5.398) 18.491 (6.635) 29.882 (7.994) 15.819 (9.497)
   Range 0.000 - 26.330 1.330 - 26.330 2.000 - 29.000 0.670 - 39.670 12.670 - 54.670 0.000 - 54.670
MMSE < 0.0011
   N-Miss 0 1 0 0 0 1
   Mean (SD) 29.058 (1.144) 29.081 (1.163) 28.222 (1.649) 27.196 (1.889) 23.155 (2.193) 27.385 (2.648)
   Range 24.000 - 30.000 24.000 - 30.000 21.000 - 30.000 19.000 - 30.000 16.000 - 30.000 16.000 - 30.000
  1. Linear Model ANOVA
  2. Pearson’s Chi-squared test

Baseline box plots

Baseline summary statistics

ADAS 13

Min. X1st.Qu. Median Mean X3rd.Qu. Max. N
CN 0.00 5.67 9.0 8.99 12.0 26.3 534
SMC 1.33 5.33 8.0 8.63 11.4 26.3 344
EMCI 2.00 9.00 12.0 12.86 16.0 29.0 407
LMCI 0.67 13.67 18.3 18.49 23.1 39.7 672
AD 12.67 24.00 29.3 29.88 34.7 54.7 393

MMSE

Min. X1st.Qu. Median Mean X3rd.Qu. Max. N
CN 24 29 29 29.1 30 30 534
SMC 24 29 29 29.1 30 30 347
EMCI 21 27 29 28.2 29 30 410
LMCI 19 26 27 27.2 29 30 675
AD 16 21 23 23.2 25 30 401

CDR-SB

Min. X1st.Qu. Median Mean X3rd.Qu. Max. N
CN 0 0.0 0.0 0.0309 0 1.0 534
SMC 0 0.0 0.0 0.0517 0 1.0 348
EMCI 0 0.5 1.0 1.3183 2 6.0 410
LMCI 0 1.0 1.5 1.6348 2 5.5 675
AD 1 3.5 4.5 4.4476 5 10.0 401

Pt ECog - Mem

Min. X1st.Qu. Median Mean X3rd.Qu. Max. N
CN 1 1.12 1.38 1.44 1.62 2.88 308
SMC 1 1.38 1.75 1.80 2.12 3.62 347
EMCI 1 1.75 2.25 2.28 2.81 4.00 407
LMCI 1 1.88 2.29 2.35 2.88 4.00 279
AD 1 1.88 2.38 2.42 3.00 4.00 212

Pt ECog - Total

Min. X1st.Qu. Median Mean X3rd.Qu. Max. N
CN 1 1.08 1.18 1.26 1.34 2.49 308
SMC 1 1.21 1.37 1.47 1.67 3.00 347
EMCI 1 1.38 1.69 1.83 2.18 3.82 408
LMCI 1 1.45 1.67 1.83 2.11 3.85 280
AD 1 1.43 1.79 1.92 2.28 3.61 212

SP ECog - Total

Min. X1st.Qu. Median Mean X3rd.Qu. Max. N
CN 1.00 1.00 1.05 1.14 1.20 2.87 304
SMC 1.00 1.03 1.11 1.21 1.31 2.90 342
EMCI 1.00 1.23 1.48 1.65 1.97 3.90 400
LMCI 1.00 1.38 1.75 1.91 2.31 3.72 278
AD 1.12 2.34 2.82 2.75 3.26 3.95 215