ADNI enrollment summaries using the ADNIMERGE R package

Description

This package vignette demonstrates how to use the ADNIMERGE package to generate simple enrollment and longitudinal summaries and plots with R and knitr.

Report generated from Enrollment.Rmd

Load required R packages and functions

options(digits = 3)
library(knitr)
library(ADNIMERGE)
library(ggplot2)
library(Hmisc)
library(gridExtra)
library(RColorBrewer)
source("https://adni.bitbucket.io/myfunctions.R")
theme_set(theme_bw())
dd <- adnimerge
dd$AGEC <- cut(dd$AGE, breaks = seq(39, 110, by = 10))

label(dd$PTEDUCAT) <- "Education"
label(dd$AGE) <- "Age"
label(dd$AGEC) <- "Age"
label(dd$PTGENDER) <- "Sex"
label(dd$PTETHCAT) <- "Ethnicity"
label(dd$PTRACCAT) <- "Race"
label(dd$PTMARRY) <- "Marital"
label(dd$CDRSB) <- "CDR-SB"
label(dd$ADAS11) <- "ADAS 11"
label(dd$ADAS13) <- "ADAS 13"
label(dd$MMSE) <- "MMSE"

# indicate the bl withdrawals:
BLTDS <- subset(treatdis, VISCODE == "bl" & WDRAWTYPE == "Full")$RID
dd$VISCODE <- with(dd, ifelse(VISCODE == "bl" & RID %in% BLTDS, "blwd", VISCODE))

Demographic Summaries by Diagnosis

Baseline

# Subsetting on RID < 2000 excludes ADNIGO/2 subjects
summary(DX.bl ~ AGE + AGEC + PTGENDER + PTEDUCAT + PTMARRY + PTETHCAT + PTRACCAT + 
    CDRSB + ADAS13 + MMSE, data = dd, subset = VISCODE %in% c("bl", "blwd"), method = "reverse", 
    test = TRUE, overall = TRUE)

Descriptive Statistics by Baseline Dx

N CN (N=518) SMC (N=303) EMCI (N=402) LMCI (N=657) AD (N=398) Combined (N=2278) Test Statistic
Age [Years] 2286
   69.9/73.2/77.7
   66.8/70.2/75.8
   65.9/71.5/76.4
   69.2/74.3/79.2
   70.5/75.3/80.3
   68.2/73.2/78.3
F=21.7 d.f.=4,2269 P<0.001
Age : (39,49] 2286
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
Chi-square=168 d.f.=16 P<0.001
(49,59]
      1%  (   5)
      2%  (   6)
      4%  (  17)
      3%  (  21)
      4%  (  16)
      3%  (  65)
(59,69]
     19%  (  99)
     41%  ( 125)
     36%  ( 143)
     21%  ( 137)
     17%  (  66)
     25%  ( 570)
(69,79]
     61%  ( 317)
     45%  ( 137)
     44%  ( 177)
     49%  ( 322)
     46%  ( 185)
     50%  (1138)
(79,89]
     18%  (  95)
     10%  (  31)
     16%  (  64)
     26%  ( 172)
     31%  ( 124)
     21%  ( 486)
(89,99]
      0%  (   1)
      1%  (   4)
      0%  (   0)
      0%  (   3)
      2%  (   7)
      1%  (  15)
(99,109]
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
Sex : Male 2290
     47%  ( 244)
     38%  ( 116)
     56%  ( 226)
     61%  ( 403)
     56%  ( 224)
     53%  (1213)
Chi-square=55.3 d.f.=4 P<0.001
Education 2290
      14/16/18
      16/17/18
      14/16/18
      14/16/18
      13/16/18
      14/16/18
F=15.5 d.f.=4,2273 P<0.001
Marital : Divorced 2290
     10%  (  54)
     13%  (  39)
     11%  (  43)
      8%  (  53)
      4%  (  14)
      9%  ( 203)
Chi-square=64 d.f.=16 P<0.001
Married
     69%  ( 360)
     72%  ( 217)
     78%  ( 313)
     78%  ( 513)
     84%  ( 336)
     76%  (1739)
Never married
      5%  (  27)
      5%  (  15)
      4%  (  16)
      2%  (  12)
      3%  (  10)
      4%  (  80)
Unknown
      0%  (   1)
      0%  (   1)
      1%  (   4)
      0%  (   2)
      0%  (   0)
      0%  (   8)
Widowed
     15%  (  76)
     10%  (  31)
      6%  (  26)
     12%  (  77)
     10%  (  38)
     11%  ( 248)
Ethnicity : Unknown 2290
      0%  (   2)
      1%  (   2)
      0%  (   2)
      0%  (   3)
      1%  (   3)
      1%  (  12)
Chi-square=6.13 d.f.=8 P=0.632
Not Hisp/Latino
     95%  ( 494)
     95%  ( 289)
     94%  ( 378)
     97%  ( 636)
     96%  ( 381)
     96%  (2178)
Hisp/Latino
      4%  (  22)
      4%  (  12)
      5%  (  22)
      3%  (  18)
      4%  (  14)
      4%  (  88)
Race : Am Indian/Alaskan 2290
      0%  (   2)
      0%  (   0)
      0%  (   2)
      0%  (   1)
      0%  (   0)
      0%  (   5)
Chi-square=54 d.f.=24 P<0.001
Asian
      2%  (   9)
      3%  (  10)
      1%  (   5)
      2%  (  12)
      3%  (  10)
      2%  (  46)
Hawaiian/Other PI
      0%  (   0)
      0%  (   0)
      0%  (   1)
      0%  (   1)
      0%  (   0)
      0%  (   2)
Black
      6%  (  32)
      8%  (  23)
      2%  (  10)
      5%  (  30)
      4%  (  17)
      5%  ( 112)
White
     91%  ( 473)
     85%  ( 259)
     93%  ( 372)
     93%  ( 609)
     92%  ( 367)
     91%  (2080)
More than one
      0%  (   2)
      3%  (  10)
      2%  (   8)
      0%  (   3)
      1%  (   4)
      1%  (  27)
Unknown
      0%  (   0)
      0%  (   1)
      1%  (   4)
      0%  (   1)
      0%  (   0)
      0%  (   6)
CDR-SB 2290
   0.00/0.00/0.00
   0.00/0.00/0.00
   0.50/1.00/1.50
   1.00/1.50/2.00
   3.50/4.50/5.00
   0.00/1.00/2.38
F=2899 d.f.=4,2273 P<0.001
ADAS 13 2265
   6.67/ 9.67/12.67
   8.33/11.00/14.33
   9.00/13.67/17.00
  14.67/18.67/23.33
  24.67/29.67/35.00
  10.00/15.00/22.33
F=667 d.f.=4,2252 P<0.001
MMSE 2290
      29/29/30
      29/29/30
      28/29/29
      26/27/29
      21/23/25
      26/28/29
F=602 d.f.=4,2273 P<0.001

Demographic Summaries by Diagnosis

Baseline

# Subsetting on RID > 2000 excludes ADNI1 subjects
summary(DX.bl ~ AGE + AGEC + PTGENDER + PTEDUCAT + PTMARRY + PTETHCAT + PTRACCAT + 
    CDRSB + ADAS13 + MMSE, data = dd, subset = VISCODE == "bl", method = "reverse", 
    test = TRUE, overall = TRUE)

Descriptive Statistics by Baseline Dx

N CN (N=511) SMC (N=300) EMCI (N=391) LMCI (N=645) AD (N=388) Combined (N=2235) Test Statistic
Age [Years] 2243
    69.9/73.2/77.7
    66.8/70.2/75.8
    66.1/71.5/76.4
    69.2/74.3/79.2
    70.4/75.3/80.3
    68.2/73.2/78.2
F=20.8 d.f.=4,2226 P<0.001
Age : (39,49] 2243
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
Chi-square=163 d.f.=16 P<0.001
(49,59]
      1%  (   5)
      2%  (   6)
      4%  (  16)
      3%  (  20)
      4%  (  16)
      3%  (  63)
(59,69]
     19%  (  97)
     41%  ( 124)
     35%  ( 138)
     21%  ( 135)
     16%  (  64)
     25%  ( 558)
(69,79]
     61%  ( 313)
     45%  ( 135)
     45%  ( 174)
     49%  ( 317)
     47%  ( 181)
     50%  (1120)
(79,89]
     18%  (  94)
     10%  (  31)
     16%  (  62)
     26%  ( 168)
     31%  ( 120)
     21%  ( 475)
(89,99]
      0%  (   1)
      1%  (   4)
      0%  (   0)
      0%  (   3)
      2%  (   7)
      1%  (  15)
(99,109]
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
      0%  (   0)
Sex : Male 2247
     47%  ( 242)
     38%  ( 114)
     57%  ( 222)
     62%  ( 397)
     56%  ( 219)
     53%  (1194)
Chi-square=56.5 d.f.=4 P<0.001
Education 2247
    14.0/16.0/18.0
    15.8/17.0/18.0
    14.0/16.0/18.0
    14.0/16.0/18.0
    13.0/16.0/18.0
    14.0/16.0/18.0
F=15.1 d.f.=4,2230 P<0.001
Marital : Divorced 2247
     10%  (  53)
     13%  (  39)
     10%  (  41)
      8%  (  53)
      4%  (  14)
      9%  ( 200)
Chi-square=63 d.f.=16 P<0.001
Married
     70%  ( 357)
     72%  ( 216)
     79%  ( 307)
     78%  ( 503)
     84%  ( 327)
     77%  (1710)
Never married
      5%  (  26)
      5%  (  15)
      4%  (  15)
      2%  (  11)
      3%  (  10)
      3%  (  77)
Unknown
      0%  (   1)
      0%  (   1)
      1%  (   4)
      0%  (   2)
      0%  (   0)
      0%  (   8)
Widowed
     14%  (  74)
     10%  (  29)
      6%  (  24)
     12%  (  76)
     10%  (  37)
     11%  ( 240)
Ethnicity : Unknown 2247
      0%  (   2)
      1%  (   2)
      1%  (   2)
      0%  (   3)
      1%  (   3)
      1%  (  12)
Chi-square=6.4 d.f.=8 P=0.603
Not Hisp/Latino
     95%  ( 487)
     95%  ( 286)
     94%  ( 368)
     97%  ( 625)
     96%  ( 372)
     96%  (2138)
Hisp/Latino
      4%  (  22)
      4%  (  12)
      5%  (  21)
      3%  (  17)
      3%  (  13)
      4%  (  85)
Race : Am Indian/Alaskan 2247
      0%  (   2)
      0%  (   0)
      1%  (   2)
      0%  (   1)
      0%  (   0)
      0%  (   5)
Chi-square=54.5 d.f.=24 P<0.001
Asian
      2%  (   9)
      3%  (  10)
      1%  (   5)
      2%  (  12)
      3%  (  10)
      2%  (  46)
Hawaiian/Other PI
      0%  (   0)
      0%  (   0)
      0%  (   1)
      0%  (   1)
      0%  (   0)
      0%  (   2)
Black
      6%  (  32)
      8%  (  23)
      2%  (   9)
      4%  (  29)
      4%  (  17)
      5%  ( 110)
White
     91%  ( 466)
     85%  ( 256)
     93%  ( 363)
     93%  ( 598)
     92%  ( 357)
     91%  (2040)
More than one
      0%  (   2)
      3%  (  10)
      2%  (   7)
      0%  (   3)
      1%  (   4)
      1%  (  26)
Unknown
      0%  (   0)
      0%  (   1)
      1%  (   4)
      0%  (   1)
      0%  (   0)
      0%  (   6)
CDR-SB 2247
     0.0/0.0/0.0
     0.0/0.0/0.0
     0.5/1.0/2.0
     1.0/1.5/2.0
     3.5/4.5/5.0
     0.0/1.0/2.0
F=2872 d.f.=4,2230 P<0.001
ADAS 13 2226
   6.67/ 9.67/12.67
   8.67/11.33/14.33
   9.00/13.84/17.00
  14.67/19.00/23.67
  24.33/29.50/35.00
  10.00/15.00/22.33
F=649 d.f.=4,2213 P<0.001
MMSE 2247
       29/29/30
       29/29/30
       28/29/29
       26/27/29
       21/23/25
       26/28/29
F=584 d.f.=4,2230 P<0.001

Baseline box plots

dd1 <- subset(dd, VISCODE == "bl" & !is.na(DX.bl), c("RID", "DX.bl", "ADAS13", "CDRSB", 
    "MMSE", "EcogPtMem", "EcogSPMem", "EcogPtTotal", "EcogSPTotal"))
ggplot(dd1, aes(DX.bl, ADAS13)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, MMSE)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, CDRSB)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, EcogPtMem)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Self Memory")

ggplot(dd1, aes(DX.bl, EcogSPMem)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Partner Memory")

ggplot(dd1, aes(DX.bl, EcogPtTotal)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Self Total")

ggplot(dd1, aes(DX.bl, EcogSPTotal)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Partner Total")

Baseline summary statistics

cols <- c("ADAS13", "MMSE", "CDRSB", "EcogPtMem", "EcogPtTotal", "EcogSPTotal")
for (cc in cols) {
    dd1$x <- dd1[, cc]
    tab <- with(dd1, Hmisc::summarize(x, by = DX.bl, FUN = summary.default, stat.name = "N"))
    cat("\n### ", label(dd1[, cc]), "\n")
    rownames(tab) <- tab[, 1]
    kable(tab[, -1])
}

###  ADAS 13 

###  MMSE 

###  CDR-SB 

###  Pt ECog - Mem 

###  Pt ECog - Total 

###  SP ECog - Total 

Longitudinal plots


\clearpage
\subsection{ ADAS 13 change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $270$&   $-11.00$&   $-2.00$&   $ 0.000$&   $-0.3850$&   $ 2.00$&   $11.0$&   $ 3.43$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $264$&   $-11.00$&   $-3.00$&   $-0.335$&   $-0.5240$&   $ 2.00$&   $11.0$&   $ 3.73$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $373$&   $-10.00$&   $-2.00$&   $-0.330$&   $-0.3160$&   $ 2.00$&   $13.3$&   $ 3.50$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 45$&   $ -9.33$&   $-2.00$&   $-1.000$&   $-0.4440$&   $ 2.00$&   $11.0$&   $ 3.88$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $161$&   $ -8.00$&   $-2.00$&   $ 1.670$&   $ 1.3600$&   $ 4.00$&   $15.0$&   $ 4.63$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 53$&   $ -1.67$&   $ 2.67$&   $ 4.330$&   $ 5.1500$&   $ 7.00$&   $18.0$&   $ 4.47$\tabularnewline
   ~~72&   $119$&   $ -2.67$&   $ 2.00$&   $ 4.670$&   $ 5.4700$&   $ 7.67$&   $23.7$&   $ 4.65$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 55$&   $ -4.33$&   $ 3.33$&   $ 6.000$&   $ 7.1200$&   $ 8.84$&   $28.3$&   $ 6.30$\tabularnewline
   ~~96&   $ 44$&   $ -5.33$&   $ 2.00$&   $ 5.160$&   $ 5.6100$&   $ 7.83$&   $23.0$&   $ 5.49$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  6$&   $  5.00$&   $ 6.33$&   $ 8.660$&   $ 8.8300$&   $11.20$&   $13.0$&   $ 3.33$\tabularnewline
   ~~120&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $429$&   $-12.00$&   $-3.00$&   $ 0.000$&   $ 0.0583$&   $ 3.00$&   $16.0$&   $ 4.38$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $526$&   $-15.00$&   $-3.00$&   $ 0.000$&   $ 0.1110$&   $ 3.00$&   $54.0$&   $ 4.99$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $404$&   $-11.00$&   $-2.33$&   $ 0.000$&   $ 1.1800$&   $ 4.00$&   $21.0$&   $ 5.49$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $318$&   $-14.00$&   $-2.00$&   $ 1.000$&   $ 2.0600$&   $ 5.00$&   $49.0$&   $ 7.44$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $252$&   $-12.00$&   $-2.00$&   $ 1.000$&   $ 3.4800$&   $ 6.00$&   $55.0$&   $ 9.57$\tabularnewline
   ~~60&   $139$&   $ -7.00$&   $ 0.00$&   $ 3.000$&   $ 5.5000$&   $ 8.16$&   $71.0$&   $10.90$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~72&   $101$&   $ -5.00$&   $ 2.00$&   $ 4.670$&   $ 5.7600$&   $ 8.00$&   $37.0$&   $ 6.79$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 88$&   $ -3.33$&   $ 2.67$&   $ 5.340$&   $ 6.8900$&   $ 9.42$&   $24.7$&   $ 6.24$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
   ~~96&   $ 69$&   $ -5.00$&   $ 3.00$&   $ 6.000$&   $ 8.0700$&   $11.30$&   $38.7$&   $ 7.90$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 25$&   $ -5.67$&   $ 3.00$&   $ 5.330$&   $ 6.5200$&   $ 8.67$&   $25.0$&   $ 6.65$\tabularnewline
   ~~120&   $  4$&   $  1.33$&   $ 2.83$&   $ 8.330$&   $10.7000$&   $16.20$&   $25.0$&   $10.90$\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $127$&   $-12.00$&   $-1.50$&   $ 2.000$&   $ 2.3800$&   $ 6.50$&   $23.0$&   $ 5.62$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $135$&   $-13.00$&   $ 0.33$&   $ 3.670$&   $ 4.6600$&   $ 8.00$&   $27.0$&   $ 6.35$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $ 40$&   $ -5.00$&   $ 2.83$&   $ 6.840$&   $ 8.6200$&   $13.00$&   $36.0$&   $ 9.02$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $  1$&   $  8.00$&   $ 8.00$&   $ 8.000$&   $ 8.0000$&   $ 8.00$&   $ 8.0$&   $$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $  2$&   $  6.33$&   $ 7.41$&   $ 8.500$&   $ 8.5000$&   $ 9.59$&   $10.7$&   $ 3.07$\tabularnewline
   ~~72&   $  1$&   $ 10.00$&   $10.00$&   $10.000$&   $10.0000$&   $10.00$&   $10.0$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ MMSE change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $274$&   $ -4$&   $-1.00$&   $ 0.0$&   $-0.0547$&   $ 1.00$&   $ 4$&   $1.40$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $267$&   $ -8$&   $-1.00$&   $ 0.0$&   $-0.2170$&   $ 1.00$&   $ 4$&   $1.59$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $381$&   $ -5$&   $-1.00$&   $ 0.0$&   $-0.1150$&   $ 1.00$&   $ 4$&   $1.42$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 48$&   $ -5$&   $-1.00$&   $ 0.0$&   $-0.3750$&   $ 1.00$&   $ 4$&   $1.78$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $161$&   $ -7$&   $-1.00$&   $ 0.0$&   $-0.2730$&   $ 1.00$&   $ 4$&   $1.69$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 53$&   $-10$&   $-1.00$&   $ 0.0$&   $-0.1890$&   $ 0.00$&   $ 4$&   $1.97$\tabularnewline
   ~~72&   $118$&   $ -8$&   $-1.00$&   $ 0.0$&   $-0.3310$&   $ 1.00$&   $ 4$&   $1.91$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 54$&   $ -7$&   $-2.00$&   $ 0.0$&   $-1.0400$&   $ 0.00$&   $ 3$&   $1.93$\tabularnewline
   ~~96&   $ 45$&   $ -4$&   $-2.00$&   $ 0.0$&   $-0.3780$&   $ 1.00$&   $ 4$&   $1.68$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  6$&   $ -3$&   $-1.50$&   $ 0.0$&   $-0.6670$&   $ 0.00$&   $ 1$&   $1.51$\tabularnewline
   ~~120&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $430$&   $-10$&   $-2.00$&   $ 0.0$&   $-0.4490$&   $ 1.00$&   $ 5$&   $1.88$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $530$&   $-11$&   $-2.00$&   $ 0.0$&   $-0.5250$&   $ 1.00$&   $ 6$&   $2.09$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $410$&   $-12$&   $-2.00$&   $ 0.0$&   $-0.9150$&   $ 1.00$&   $ 6$&   $2.50$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $319$&   $-23$&   $-2.00$&   $-1.0$&   $-1.2400$&   $ 1.00$&   $ 6$&   $3.31$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $256$&   $-20$&   $-3.00$&   $-1.0$&   $-1.6000$&   $ 1.00$&   $ 5$&   $3.82$\tabularnewline
   ~~60&   $143$&   $-30$&   $-3.00$&   $-1.0$&   $-1.9900$&   $ 0.00$&   $ 4$&   $4.64$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~72&   $105$&   $-24$&   $-2.00$&   $ 0.0$&   $-1.5000$&   $ 1.00$&   $ 5$&   $4.17$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 93$&   $-20$&   $-3.00$&   $-1.0$&   $-1.7300$&   $ 1.00$&   $ 6$&   $4.30$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
   ~~96&   $ 70$&   $-12$&   $-2.75$&   $-1.0$&   $-1.6700$&   $ 1.00$&   $ 5$&   $3.70$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 26$&   $ -5$&   $-2.00$&   $-0.5$&   $-0.8460$&   $ 0.75$&   $ 2$&   $1.91$\tabularnewline
   ~~120&   $  5$&   $ -5$&   $-2.00$&   $-1.0$&   $-1.2000$&   $ 0.00$&   $ 2$&   $2.59$\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $131$&   $-16$&   $-3.00$&   $-1.0$&   $-1.1800$&   $ 1.00$&   $ 8$&   $3.07$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $140$&   $-19$&   $-5.00$&   $-2.0$&   $-2.5000$&   $ 0.00$&   $ 5$&   $4.15$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $ 42$&   $-15$&   $-6.00$&   $-4.0$&   $-4.3300$&   $-2.00$&   $ 3$&   $3.85$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $  1$&   $ -2$&   $-2.00$&   $-2.0$&   $-2.0000$&   $-2.00$&   $-2$&   $$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $  2$&   $ -4$&   $-3.00$&   $-2.0$&   $-2.0000$&   $-1.00$&   $ 0$&   $2.83$\tabularnewline
   ~~72&   $  2$&   $ -5$&   $-4.50$&   $-4.0$&   $-4.0000$&   $-3.50$&   $-3$&   $1.41$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ CDR-SB change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.0$&   $ 0.00$&   $ 0.00$&   $ 0.0879$&   $ 0.000$&   $ 2.5$&   $0.348$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $265$&   $-1.0$&   $ 0.00$&   $ 0.00$&   $ 0.1260$&   $ 0.000$&   $ 4.0$&   $0.492$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $400$&   $-1.0$&   $ 0.00$&   $ 0.00$&   $ 0.1500$&   $ 0.000$&   $ 5.0$&   $0.560$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 45$&   $-0.5$&   $ 0.00$&   $ 0.00$&   $ 0.5220$&   $ 0.500$&   $ 5.0$&   $1.190$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $156$&   $-0.5$&   $ 0.00$&   $ 0.00$&   $ 0.2020$&   $ 0.000$&   $ 5.0$&   $0.686$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 56$&   $-0.5$&   $ 0.00$&   $ 0.00$&   $ 0.5540$&   $ 0.500$&   $11.0$&   $1.710$\tabularnewline
   ~~72&   $123$&   $-0.5$&   $ 0.00$&   $ 0.00$&   $ 0.4270$&   $ 0.250$&   $10.0$&   $1.240$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 62$&   $-0.5$&   $ 0.00$&   $ 0.00$&   $ 0.8630$&   $ 1.000$&   $12.0$&   $1.980$\tabularnewline
   ~~96&   $ 48$&   $-0.5$&   $ 0.00$&   $ 0.00$&   $ 0.7600$&   $ 0.500$&   $15.5$&   $2.350$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  8$&   $ 0.0$&   $ 0.00$&   $ 0.00$&   $ 0.3120$&   $ 0.625$&   $ 1.0$&   $0.458$\tabularnewline
   ~~120&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $426$&   $-3.5$&   $-0.50$&   $ 0.00$&   $ 0.1310$&   $ 0.500$&   $ 3.0$&   $0.807$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $528$&   $-3.0$&   $-0.50$&   $ 0.00$&   $ 0.1950$&   $ 0.500$&   $ 5.5$&   $1.020$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $424$&   $-3.0$&   $-0.50$&   $ 0.00$&   $ 0.5870$&   $ 1.000$&   $11.5$&   $1.650$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $329$&   $-3.5$&   $-0.50$&   $ 0.00$&   $ 0.9010$&   $ 1.500$&   $12.5$&   $2.370$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $257$&   $-3.5$&   $-0.50$&   $ 0.00$&   $ 1.1200$&   $ 2.000$&   $16.0$&   $2.910$\tabularnewline
   ~~60&   $141$&   $-3.0$&   $-0.50$&   $ 0.00$&   $ 0.9260$&   $ 1.500$&   $14.5$&   $2.650$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~72&   $109$&   $-3.0$&   $-0.50$&   $ 0.00$&   $ 1.2200$&   $ 1.500$&   $15.5$&   $3.430$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 95$&   $-3.5$&   $-0.50$&   $ 0.00$&   $ 1.3400$&   $ 1.500$&   $15.0$&   $3.410$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
   ~~96&   $ 77$&   $-3.5$&   $-0.50$&   $ 0.00$&   $ 1.4000$&   $ 1.500$&   $14.0$&   $3.560$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 35$&   $-2.5$&   $-0.75$&   $ 0.00$&   $ 1.4000$&   $ 1.500$&   $16.5$&   $3.800$\tabularnewline
   ~~120&   $  6$&   $-1.5$&   $-0.50$&   $-0.25$&   $ 0.0833$&   $ 1.120$&   $ 1.5$&   $1.200$\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $131$&   $-2.5$&   $ 0.00$&   $ 0.50$&   $ 0.8130$&   $ 1.500$&   $ 9.0$&   $1.540$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $149$&   $-2.0$&   $ 0.00$&   $ 1.00$&   $ 1.8600$&   $ 2.500$&   $11.5$&   $2.470$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $ 44$&   $-1.0$&   $ 1.00$&   $ 2.50$&   $ 3.2200$&   $ 5.000$&   $11.5$&   $2.870$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $  1$&   $ 2.0$&   $ 2.00$&   $ 2.00$&   $ 2.0000$&   $ 2.000$&   $ 2.0$&   $$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $  1$&   $ 3.0$&   $ 3.00$&   $ 3.00$&   $ 3.0000$&   $ 3.000$&   $ 3.0$&   $$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $  4$&   $ 2.0$&   $ 4.25$&   $ 8.00$&   $ 7.3800$&   $11.100$&   $11.5$&   $4.640$\tabularnewline
   ~~72&   $  4$&   $ 7.0$&   $ 8.12$&   $10.00$&   $10.4000$&   $12.200$&   $14.5$&   $3.330$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ Pt ECog - Mem change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.500$&   $-0.2500$&   $ 0.0000$&   $ 0.0303$&   $ 0.250$&   $ 1.6200$&   $0.431$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $268$&   $-1.380$&   $-0.2500$&   $ 0.0000$&   $ 0.0244$&   $ 0.250$&   $ 1.6200$&   $0.427$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $411$&   $-2.000$&   $-0.2500$&   $ 0.0000$&   $ 0.0169$&   $ 0.250$&   $ 1.7500$&   $0.442$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 47$&   $-0.589$&   $-0.2500$&   $ 0.0000$&   $-0.0338$&   $ 0.125$&   $ 0.7500$&   $0.306$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $163$&   $-1.380$&   $-0.2500$&   $ 0.0000$&   $ 0.0563$&   $ 0.375$&   $ 2.1200$&   $0.495$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 57$&   $-1.430$&   $ 0.0000$&   $ 0.1250$&   $ 0.1460$&   $ 0.375$&   $ 1.3800$&   $0.494$\tabularnewline
   ~~72&   $122$&   $-1.320$&   $-0.1250$&   $ 0.1250$&   $ 0.1690$&   $ 0.500$&   $ 1.6200$&   $0.539$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 63$&   $-1.500$&   $-0.1250$&   $ 0.1250$&   $ 0.1930$&   $ 0.500$&   $ 1.8200$&   $0.606$\tabularnewline
   ~~96&   $ 50$&   $-1.120$&   $-0.1250$&   $ 0.0625$&   $ 0.2010$&   $ 0.500$&   $ 2.2500$&   $0.609$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  8$&   $-0.500$&   $-0.0625$&   $ 0.1250$&   $ 0.0781$&   $ 0.281$&   $ 0.5000$&   $0.327$\tabularnewline
   ~~120&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $428$&   $-2.120$&   $-0.3750$&   $-0.1250$&   $-0.1040$&   $ 0.250$&   $ 1.6200$&   $0.539$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $532$&   $-2.250$&   $-0.3750$&   $ 0.0000$&   $-0.0608$&   $ 0.254$&   $ 1.6200$&   $0.601$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $422$&   $-2.880$&   $-0.3750$&   $ 0.0000$&   $-0.0189$&   $ 0.375$&   $ 2.5000$&   $0.651$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $322$&   $-2.380$&   $-0.3750$&   $-0.0804$&   $-0.0418$&   $ 0.375$&   $ 2.5000$&   $0.633$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $250$&   $-2.500$&   $-0.5000$&   $-0.1250$&   $-0.0975$&   $ 0.312$&   $ 2.3600$&   $0.725$\tabularnewline
   ~~60&   $141$&   $-1.500$&   $-0.3750$&   $ 0.0000$&   $ 0.0201$&   $ 0.500$&   $ 1.7500$&   $0.596$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~72&   $103$&   $-2.120$&   $-0.3750$&   $ 0.0000$&   $ 0.0223$&   $ 0.500$&   $ 1.7500$&   $0.742$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 95$&   $-2.380$&   $-0.3750$&   $-0.1250$&   $-0.0728$&   $ 0.250$&   $ 2.0000$&   $0.658$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
   ~~96&   $ 76$&   $-2.500$&   $-0.5000$&   $-0.2500$&   $-0.1830$&   $ 0.250$&   $ 2.2100$&   $0.709$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 35$&   $-2.250$&   $-0.5000$&   $-0.1250$&   $-0.1510$&   $ 0.188$&   $ 1.8800$&   $0.795$\tabularnewline
   ~~120&   $  7$&   $-0.625$&   $-0.5620$&   $-0.2500$&   $ 0.0357$&   $ 0.312$&   $ 1.6200$&   $0.816$\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $124$&   $-1.880$&   $-0.4060$&   $ 0.0000$&   $-0.0592$&   $ 0.375$&   $ 1.7500$&   $0.725$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $127$&   $-2.000$&   $-0.4730$&   $-0.0357$&   $-0.1340$&   $ 0.375$&   $ 2.0000$&   $0.734$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $ 32$&   $-1.750$&   $-0.5000$&   $-0.1880$&   $-0.0954$&   $ 0.277$&   $ 2.1200$&   $0.739$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $  1$&   $-0.500$&   $-0.5000$&   $-0.5000$&   $-0.5000$&   $-0.500$&   $-0.5000$&   $$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $  2$&   $-0.875$&   $-0.6650$&   $-0.4550$&   $-0.4550$&   $-0.246$&   $-0.0357$&   $0.593$\tabularnewline
   ~~72&   $  1$&   $-0.875$&   $-0.8750$&   $-0.8750$&   $-0.8750$&   $-0.875$&   $-0.8750$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ SP ECog - Mem change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $263$&   $-1.380$&   $-0.1250$&   $ 0.000$&   $ 0.01720$&   $0.125$&   $1.620$&   $0.361$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $262$&   $-1.500$&   $-0.1250$&   $ 0.000$&   $ 0.04250$&   $0.250$&   $2.120$&   $0.407$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $391$&   $-1.500$&   $-0.1250$&   $ 0.000$&   $ 0.04090$&   $0.250$&   $2.120$&   $0.415$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 44$&   $-1.380$&   $-0.1250$&   $ 0.125$&   $ 0.17200$&   $0.319$&   $2.120$&   $0.604$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $155$&   $-1.250$&   $-0.1550$&   $ 0.000$&   $ 0.11400$&   $0.250$&   $2.120$&   $0.490$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 54$&   $-0.750$&   $-0.1250$&   $ 0.000$&   $ 0.14100$&   $0.250$&   $2.460$&   $0.568$\tabularnewline
   ~~72&   $122$&   $-1.500$&   $-0.1250$&   $ 0.000$&   $ 0.20600$&   $0.469$&   $2.250$&   $0.623$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 62$&   $-2.380$&   $-0.0938$&   $ 0.134$&   $ 0.36500$&   $0.625$&   $2.750$&   $0.883$\tabularnewline
   ~~96&   $ 48$&   $-1.380$&   $-0.1250$&   $ 0.000$&   $ 0.23700$&   $0.500$&   $3.000$&   $0.690$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  8$&   $-0.125$&   $ 0.3120$&   $ 0.500$&   $ 0.54700$&   $0.750$&   $1.250$&   $0.467$\tabularnewline
   ~~120&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $424$&   $-1.880$&   $-0.2500$&   $ 0.000$&   $ 0.00345$&   $0.375$&   $2.120$&   $0.561$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $526$&   $-2.750$&   $-0.2500$&   $ 0.000$&   $ 0.01600$&   $0.330$&   $2.250$&   $0.587$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $424$&   $-1.880$&   $-0.2500$&   $ 0.000$&   $ 0.10700$&   $0.500$&   $2.120$&   $0.661$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $321$&   $-2.250$&   $-0.2500$&   $ 0.125$&   $ 0.15500$&   $0.500$&   $2.140$&   $0.706$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $245$&   $-1.750$&   $-0.2500$&   $ 0.125$&   $ 0.22500$&   $0.500$&   $2.880$&   $0.710$\tabularnewline
   ~~60&   $137$&   $-1.620$&   $-0.1790$&   $ 0.125$&   $ 0.27000$&   $0.625$&   $2.500$&   $0.783$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~72&   $109$&   $-1.620$&   $-0.2500$&   $ 0.125$&   $ 0.20200$&   $0.625$&   $2.290$&   $0.697$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 98$&   $-1.250$&   $-0.2630$&   $ 0.125$&   $ 0.25900$&   $0.750$&   $2.500$&   $0.823$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
   ~~96&   $ 76$&   $-2.000$&   $-0.1350$&   $ 0.250$&   $ 0.26800$&   $0.625$&   $2.380$&   $0.778$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 36$&   $-0.750$&   $-0.2500$&   $ 0.125$&   $ 0.31500$&   $0.750$&   $2.500$&   $0.745$\tabularnewline
   ~~120&   $  6$&   $-0.857$&   $-0.4510$&   $-0.152$&   $-0.09230$&   $0.188$&   $0.857$&   $0.604$\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $130$&   $-2.750$&   $-0.2500$&   $ 0.000$&   $ 0.04210$&   $0.479$&   $1.620$&   $0.616$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $147$&   $-1.620$&   $ 0.0000$&   $ 0.125$&   $ 0.21200$&   $0.500$&   $2.120$&   $0.507$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $ 44$&   $-1.540$&   $-0.0312$&   $ 0.000$&   $ 0.14200$&   $0.375$&   $1.500$&   $0.566$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $  1$&   $ 1.250$&   $ 1.2500$&   $ 1.250$&   $ 1.25000$&   $1.250$&   $1.250$&   $$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $  1$&   $ 0.000$&   $ 0.0000$&   $ 0.000$&   $ 0.00000$&   $0.000$&   $0.000$&   $$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $  4$&   $ 0.000$&   $ 0.0938$&   $ 0.625$&   $ 0.84400$&   $1.380$&   $2.120$&   $0.992$\tabularnewline
   ~~72&   $  4$&   $ 0.000$&   $ 0.8440$&   $ 1.470$&   $ 1.27000$&   $1.900$&   $2.120$&   $0.943$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ Pt ECog - Total change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.140$&   $-0.103000$&   $ 0.00000$&   $ 0.017800$&   $ 0.1280$&   $ 0.8210$&   $0.253$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $268$&   $-0.751$&   $-0.103000$&   $ 0.00000$&   $ 0.029400$&   $ 0.1280$&   $ 1.4600$&   $0.253$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $411$&   $-1.340$&   $-0.104000$&   $ 0.00000$&   $ 0.013700$&   $ 0.1320$&   $ 1.1800$&   $0.294$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 47$&   $-0.526$&   $-0.103000$&   $-0.02560$&   $ 0.005560$&   $ 0.1030$&   $ 0.7440$&   $0.220$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $164$&   $-0.985$&   $-0.107000$&   $ 0.04180$&   $ 0.043100$&   $ 0.1670$&   $ 1.7200$&   $0.304$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 57$&   $-0.725$&   $-0.046600$&   $ 0.13300$&   $ 0.112000$&   $ 0.2210$&   $ 0.7270$&   $0.314$\tabularnewline
   ~~72&   $122$&   $-1.010$&   $-0.022900$&   $ 0.10600$&   $ 0.136000$&   $ 0.2640$&   $ 1.3000$&   $0.329$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 63$&   $-0.784$&   $-0.049200$&   $ 0.08160$&   $ 0.133000$&   $ 0.3040$&   $ 1.1600$&   $0.358$\tabularnewline
   ~~96&   $ 50$&   $-1.110$&   $ 0.000675$&   $ 0.08570$&   $ 0.184000$&   $ 0.2200$&   $ 2.6400$&   $0.522$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  8$&   $-0.147$&   $ 0.057900$&   $ 0.13500$&   $ 0.176000$&   $ 0.2990$&   $ 0.5140$&   $0.220$\tabularnewline
   ~~120&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $430$&   $-2.080$&   $-0.219000$&   $-0.02630$&   $-0.035000$&   $ 0.1500$&   $ 1.5900$&   $0.376$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $535$&   $-1.690$&   $-0.234000$&   $ 0.00000$&   $-0.019000$&   $ 0.1870$&   $ 1.6700$&   $0.398$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $423$&   $-1.690$&   $-0.205000$&   $ 0.00000$&   $ 0.028300$&   $ 0.2330$&   $ 1.7400$&   $0.443$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $318$&   $-1.730$&   $-0.205000$&   $ 0.02560$&   $ 0.044600$&   $ 0.3060$&   $ 1.9900$&   $0.454$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $249$&   $-2.310$&   $-0.247000$&   $ 0.02560$&   $ 0.031600$&   $ 0.3080$&   $ 2.7100$&   $0.529$\tabularnewline
   ~~60&   $139$&   $-1.210$&   $-0.141000$&   $ 0.05130$&   $ 0.072500$&   $ 0.3260$&   $ 1.1300$&   $0.438$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~72&   $103$&   $-1.130$&   $-0.165000$&   $ 0.05400$&   $ 0.095300$&   $ 0.3850$&   $ 1.4800$&   $0.467$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 95$&   $-1.090$&   $-0.200000$&   $ 0.00540$&   $ 0.017100$&   $ 0.2040$&   $ 1.6000$&   $0.476$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
   ~~96&   $ 76$&   $-1.090$&   $-0.247000$&   $ 0.00405$&   $ 0.022400$&   $ 0.1840$&   $ 2.5900$&   $0.498$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 35$&   $-0.862$&   $-0.382000$&   $-0.06610$&   $-0.058200$&   $ 0.1630$&   $ 0.7770$&   $0.426$\tabularnewline
   ~~120&   $  7$&   $-1.370$&   $-0.566000$&   $-0.00208$&   $-0.195000$&   $ 0.2280$&   $ 0.6810$&   $0.700$\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $120$&   $-1.690$&   $-0.298000$&   $ 0.02320$&   $-0.011900$&   $ 0.2840$&   $ 1.5100$&   $0.554$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $124$&   $-1.380$&   $-0.344000$&   $-0.01060$&   $ 0.000392$&   $ 0.2910$&   $ 2.1000$&   $0.553$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $ 32$&   $-1.430$&   $-0.145000$&   $ 0.07790$&   $ 0.123000$&   $ 0.4270$&   $ 2.3200$&   $0.643$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $  1$&   $ 0.553$&   $ 0.553000$&   $ 0.55300$&   $ 0.553000$&   $ 0.5530$&   $ 0.5530$&   $$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $  2$&   $-0.543$&   $-0.394000$&   $-0.24500$&   $-0.245000$&   $-0.0957$&   $ 0.0535$&   $0.422$\tabularnewline
   ~~72&   $  1$&   $-0.191$&   $-0.191000$&   $-0.19100$&   $-0.191000$&   $-0.1910$&   $-0.1910$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

\clearpage
\subsection{ SP ECog - Total change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $265$&   $-0.8790$&   $-0.0513$&   $ 0.0000$&   $ 0.00909$&   $0.0769$&   $0.846$&   $0.193$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $262$&   $-1.2100$&   $-0.0347$&   $ 0.0000$&   $ 0.03980$&   $0.0979$&   $1.620$&   $0.257$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $391$&   $-1.1300$&   $-0.0526$&   $ 0.0000$&   $ 0.03620$&   $0.0900$&   $2.000$&   $0.271$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 44$&   $-1.3300$&   $ 0.0000$&   $ 0.0599$&   $ 0.13900$&   $0.2350$&   $2.050$&   $0.477$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $156$&   $-1.0500$&   $-0.0516$&   $ 0.0000$&   $ 0.08570$&   $0.1290$&   $1.680$&   $0.341$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 54$&   $-0.5400$&   $-0.0447$&   $ 0.0395$&   $ 0.16500$&   $0.2110$&   $2.540$&   $0.509$\tabularnewline
   ~~72&   $121$&   $-0.9940$&   $-0.0513$&   $ 0.0526$&   $ 0.16700$&   $0.2660$&   $2.520$&   $0.464$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 62$&   $-1.5400$&   $ 0.0000$&   $ 0.1050$&   $ 0.31300$&   $0.3770$&   $2.950$&   $0.750$\tabularnewline
   ~~96&   $ 48$&   $-0.9940$&   $-0.0508$&   $ 0.0135$&   $ 0.10800$&   $0.1590$&   $2.470$&   $0.477$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  8$&   $-0.0301$&   $ 0.1380$&   $ 0.3050$&   $ 0.34700$&   $0.4140$&   $1.090$&   $0.343$\tabularnewline
   ~~120&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $426$&   $-1.4600$&   $-0.1670$&   $ 0.0206$&   $ 0.05150$&   $0.2540$&   $1.990$&   $0.411$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $526$&   $-2.0400$&   $-0.1280$&   $ 0.0513$&   $ 0.08610$&   $0.2840$&   $2.090$&   $0.460$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $425$&   $-1.4100$&   $-0.1050$&   $ 0.1130$&   $ 0.19000$&   $0.4050$&   $2.410$&   $0.537$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $320$&   $-2.1400$&   $-0.0995$&   $ 0.1440$&   $ 0.25500$&   $0.4890$&   $2.510$&   $0.616$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $245$&   $-2.1100$&   $-0.1030$&   $ 0.1540$&   $ 0.28400$&   $0.5710$&   $2.620$&   $0.648$\tabularnewline
   ~~60&   $137$&   $-1.0500$&   $-0.1030$&   $ 0.1660$&   $ 0.32500$&   $0.6910$&   $2.400$&   $0.676$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~72&   $109$&   $-1.1000$&   $-0.1010$&   $ 0.1520$&   $ 0.26500$&   $0.5200$&   $2.250$&   $0.622$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 98$&   $-1.3400$&   $-0.0979$&   $ 0.1580$&   $ 0.37600$&   $0.7420$&   $2.400$&   $0.781$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
   ~~96&   $ 76$&   $-1.2100$&   $-0.0488$&   $ 0.1310$&   $ 0.40500$&   $0.5990$&   $2.510$&   $0.799$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 36$&   $-0.5890$&   $-0.0621$&   $ 0.1100$&   $ 0.43800$&   $0.8620$&   $2.820$&   $0.766$\tabularnewline
   ~~120&   $  6$&   $-0.4090$&   $-0.2470$&   $-0.1090$&   $-0.08140$&   $0.0592$&   $0.316$&   $0.263$\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $130$&   $-2.5000$&   $-0.1470$&   $ 0.1260$&   $ 0.10500$&   $0.4100$&   $1.330$&   $0.524$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $148$&   $-1.4600$&   $ 0.1080$&   $ 0.3290$&   $ 0.34200$&   $0.5950$&   $1.570$&   $0.460$\tabularnewline
   ~~18&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $ 44$&   $-0.4740$&   $ 0.0819$&   $ 0.4160$&   $ 0.42200$&   $0.7730$&   $1.890$&   $0.505$\tabularnewline
   ~~30&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $  1$&   $ 1.1100$&   $ 1.1100$&   $ 1.1100$&   $ 1.11000$&   $1.1100$&   $1.110$&   $$\tabularnewline
   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $  1$&   $ 0.7180$&   $ 0.7180$&   $ 0.7180$&   $ 0.71800$&   $0.7180$&   $0.718$&   $$\tabularnewline
   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $  4$&   $-0.2410$&   $ 0.4780$&   $ 0.7580$&   $ 0.97900$&   $1.2600$&   $2.640$&   $1.200$\tabularnewline
   ~~72&   $  4$&   $ 0.6750$&   $ 1.0100$&   $ 1.2000$&   $ 1.43000$&   $1.6200$&   $2.660$&   $0.858$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

R Session Information

{r results = "markup" print(sessionInfo(), locale=FALSE)