ADNI enrollment summaries using the ADNIMERGE R package

Description

This package vignette demonstrates how to use the ADNIMERGE package to generate simple enrollment and longitudinal summaries and plots with R and knitr.

Report generated from Enrollment.Rmd

Load required R packages and functions

options(digits = 3)
library(knitr)
library(ADNIMERGE)
library(ggplot2)
library(Hmisc)
library(gridExtra)
library(RColorBrewer)
source("https://adni.bitbucket.io/myfunctions.R")
theme_set(theme_bw())

dd <- adnimerge
dd$AGEC <- cut(dd$AGE, breaks = seq(39, 110, by = 10))

label(dd$PTEDUCAT) <- "Education"
label(dd$AGE) <- "Age"
label(dd$AGEC) <- "Age"
label(dd$PTGENDER) <- "Sex"
label(dd$PTETHCAT) <- "Ethnicity"
label(dd$PTRACCAT) <- "Race"
label(dd$PTMARRY) <- "Marital"
label(dd$CDRSB) <- "CDR-SB"
label(dd$ADAS11) <- "ADAS 11"
label(dd$ADAS13) <- "ADAS 13"
label(dd$MMSE) <- "MMSE"

# indicate the bl withdrawals:
BLTDS <- subset(treatdis, VISCODE == "bl" & WDRAWTYPE == "Full")$RID
dd$VISCODE <- with(dd, ifelse(VISCODE == "bl" & RID %in% BLTDS, "blwd", VISCODE))

Demographic Summaries by Diagnosis

Baseline

# Subsetting on RID < 2000 excludes ADNIGO/2 subjects
summary(DX.bl ~ AGE + AGEC + PTGENDER + PTEDUCAT + PTMARRY + PTETHCAT + PTRACCAT + 
    CDRSB + ADAS13 + MMSE, data = dd, subset = VISCODE %in% c("bl", "blwd"), method = "reverse", 
    test = TRUE, overall = TRUE)

Descriptive Statistics by Baseline Dx

	N	CN (N=534)	SMC (N=325)	EMCI (N=411)	LMCI (N=672)	AD (N=407)	Combined (N=2349)	Test Statistic
Age [Years]	2374	`69.8/73.1/77.5`	`66.4/69.8/75.6`	`65.7/71.5/76.4`	`69.1/74.3/79.2`	`70.3/75.3/80.3`	`68.0/73.0/78.2`	F=23.7 d.f.=4,2340 P<0.001
Age : (39,49]	2374	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	Chi-square=165 d.f.=16 P<0.001
(49,59]		`2% ( 9)`	`3% ( 9)`	`5% ( 19)`	`3% ( 21)`	`4% ( 17)`	`3% ( 75)`
(59,69]		`20% ( 105)`	`42% ( 137)`	`36% ( 146)`	`21% ( 143)`	`16% ( 67)`	`26% ( 598)`
(69,79]		`61% ( 323)`	`44% ( 142)`	`44% ( 179)`	`49% ( 330)`	`47% ( 191)`	`50% (1165)`
(79,89]		`18% ( 95)`	`10% ( 33)`	`16% ( 65)`	`26% ( 172)`	`31% ( 125)`	`21% ( 490)`
(89,99]		`0% ( 1)`	`1% ( 4)`	`0% ( 1)`	`1% ( 4)`	`2% ( 7)`	`1% ( 17)`
(99,109]		`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`
Sex : Male	2378	`47% ( 252)`	`39% ( 126)`	`55% ( 227)`	`61% ( 411)`	`57% ( 230)`	`53% (1246)`	Chi-square=54.5 d.f.=4 P<0.001
Education	2378	`14/16/18`	`16/17/18`	`14/16/18`	`14/16/18`	`13/16/17`	`14/16/18`	F=16.7 d.f.=4,2344 P<0.001
Marital : Divorced	2378	`11% ( 57)`	`14% ( 44)`	`11% ( 45)`	`8% ( 55)`	`3% ( 14)`	`9% ( 215)`	Chi-square=66.5 d.f.=16 P<0.001
Married		`69% ( 369)`	`71% ( 231)`	`77% ( 318)`	`78% ( 524)`	`84% ( 343)`	`76% (1785)`
Never married		`5% ( 29)`	`5% ( 16)`	`4% ( 17)`	`2% ( 14)`	`3% ( 11)`	`4% ( 87)`
Unknown		`0% ( 1)`	`0% ( 1)`	`1% ( 4)`	`0% ( 2)`	`0% ( 0)`	`0% ( 8)`
Widowed		`15% ( 78)`	`10% ( 33)`	`7% ( 27)`	`11% ( 77)`	`10% ( 39)`	`11% ( 254)`
Ethnicity : Unknown	2378	`0% ( 2)`	`1% ( 2)`	`0% ( 2)`	`0% ( 3)`	`1% ( 3)`	`1% ( 12)`	Chi-square=8.89 d.f.=8 P=0.352
Not Hisp/Latino		`95% ( 506)`	`93% ( 301)`	`94% ( 387)`	`96% ( 647)`	`96% ( 390)`	`95% (2231)`
Hisp/Latino		`5% ( 26)`	`7% ( 22)`	`5% ( 22)`	`3% ( 22)`	`3% ( 14)`	`5% ( 106)`
Race : Am Indian/Alaskan	2378	`0% ( 2)`	`0% ( 0)`	`0% ( 2)`	`0% ( 1)`	`0% ( 0)`	`0% ( 5)`	Chi-square=58.5 d.f.=24 P<0.001
Asian		`2% ( 11)`	`4% ( 14)`	`1% ( 6)`	`2% ( 12)`	`2% ( 10)`	`2% ( 53)`
Hawaiian/Other PI		`0% ( 0)`	`0% ( 0)`	`0% ( 1)`	`0% ( 1)`	`0% ( 0)`	`0% ( 2)`
Black		`8% ( 42)`	`10% ( 31)`	`3% ( 14)`	`5% ( 34)`	`5% ( 20)`	`6% ( 141)`
White		`89% ( 476)`	`82% ( 267)`	`91% ( 376)`	`92% ( 618)`	`92% ( 373)`	`90% (2110)`
More than one		`0% ( 2)`	`3% ( 10)`	`2% ( 8)`	`0% ( 3)`	`1% ( 4)`	`1% ( 27)`
Unknown		`0% ( 1)`	`1% ( 3)`	`1% ( 4)`	`0% ( 3)`	`0% ( 0)`	`0% ( 11)`
CDR-SB	2378	`0.0/0.0/0.0`	`0.0/0.0/0.0`	`0.5/1.0/2.0`	`1.0/1.5/2.0`	`3.5/4.5/5.0`	`0.0/1.0/2.0`	F=3009 d.f.=4,2344 P<0.001
ADAS 13	2353	`5.67/ 9.00/12.00`	`5.33/ 8.00/11.67`	`9.00/12.00/16.00`	`13.67/18.33/23.00`	`24.00/29.33/35.00`	`9.00/14.00/21.67`	F=807 d.f.=4,2322 P<0.001
MMSE	2377	`29/29/30`	`29/29/30`	`28/29/29`	`26/27/29`	`21/23/25`	`26/28/29`	F=614 d.f.=4,2344 P<0.001

Demographic Summaries by Diagnosis

Baseline

# Subsetting on RID > 2000 excludes ADNI1 subjects
summary(DX.bl ~ AGE + AGEC + PTGENDER + PTEDUCAT + PTMARRY + PTETHCAT + PTRACCAT + 
    CDRSB + ADAS13 + MMSE, data = dd, subset = VISCODE == "bl", method = "reverse", 
    test = TRUE, overall = TRUE)

Descriptive Statistics by Baseline Dx

	N	CN (N=527)	SMC (N=322)	EMCI (N=400)	LMCI (N=660)	AD (N=397)	Combined (N=2306)	Test Statistic
Age [Years]	2331	`69.8/73.1/77.5`	`66.4/69.8/75.7`	`66.0/71.5/76.4`	`69.1/74.3/79.2`	`70.3/75.3/80.3`	`68.0/73.0/78.1`	F=22.8 d.f.=4,2297 P<0.001
Age : (39,49]	2331	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	Chi-square=160 d.f.=16 P<0.001
(49,59]		`2% ( 9)`	`3% ( 9)`	`5% ( 18)`	`3% ( 20)`	`4% ( 17)`	`3% ( 73)`
(59,69]		`20% ( 103)`	`42% ( 136)`	`35% ( 141)`	`21% ( 141)`	`16% ( 65)`	`25% ( 586)`
(69,79]		`61% ( 319)`	`43% ( 140)`	`44% ( 176)`	`49% ( 325)`	`47% ( 187)`	`50% (1147)`
(79,89]		`18% ( 94)`	`10% ( 33)`	`16% ( 63)`	`26% ( 168)`	`30% ( 121)`	`21% ( 479)`
(89,99]		`0% ( 1)`	`1% ( 4)`	`0% ( 1)`	`1% ( 4)`	`2% ( 7)`	`1% ( 17)`
(99,109]		`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`	`0% ( 0)`
Sex : Male	2335	`47% ( 250)`	`39% ( 124)`	`56% ( 223)`	`61% ( 405)`	`57% ( 225)`	`53% (1227)`	Chi-square=55.6 d.f.=4 P<0.001
Education	2335	`14/16/18`	`16/17/18`	`14/16/18`	`14/16/18`	`13/16/17`	`14/16/18`	F=16.3 d.f.=4,2301 P<0.001
Marital : Divorced	2335	`11% ( 56)`	`14% ( 44)`	`11% ( 43)`	`8% ( 55)`	`4% ( 14)`	`9% ( 212)`	Chi-square=65.3 d.f.=16 P<0.001
Married		`69% ( 366)`	`71% ( 230)`	`78% ( 312)`	`78% ( 514)`	`84% ( 334)`	`76% (1756)`
Never married		`5% ( 28)`	`5% ( 16)`	`4% ( 16)`	`2% ( 13)`	`3% ( 11)`	`4% ( 84)`
Unknown		`0% ( 1)`	`0% ( 1)`	`1% ( 4)`	`0% ( 2)`	`0% ( 0)`	`0% ( 8)`
Widowed		`14% ( 76)`	`10% ( 31)`	`6% ( 25)`	`12% ( 76)`	`10% ( 38)`	`11% ( 246)`
Ethnicity : Unknown	2335	`0% ( 2)`	`1% ( 2)`	`0% ( 2)`	`0% ( 3)`	`1% ( 3)`	`1% ( 12)`	Chi-square=9.69 d.f.=8 P=0.288
Not Hisp/Latino		`95% ( 499)`	`93% ( 298)`	`94% ( 377)`	`96% ( 636)`	`96% ( 381)`	`95% (2191)`
Hisp/Latino		`5% ( 26)`	`7% ( 22)`	`5% ( 21)`	`3% ( 21)`	`3% ( 13)`	`4% ( 103)`
Race : Am Indian/Alaskan	2335	`0% ( 2)`	`0% ( 0)`	`0% ( 2)`	`0% ( 1)`	`0% ( 0)`	`0% ( 5)`	Chi-square=58.6 d.f.=24 P<0.001
Asian		`2% ( 11)`	`4% ( 14)`	`2% ( 6)`	`2% ( 12)`	`3% ( 10)`	`2% ( 53)`
Hawaiian/Other PI		`0% ( 0)`	`0% ( 0)`	`0% ( 1)`	`0% ( 1)`	`0% ( 0)`	`0% ( 2)`
Black		`8% ( 42)`	`10% ( 31)`	`3% ( 13)`	`5% ( 33)`	`5% ( 20)`	`6% ( 139)`
White		`89% ( 469)`	`82% ( 264)`	`92% ( 367)`	`92% ( 607)`	`91% ( 363)`	`90% (2070)`
More than one		`0% ( 2)`	`3% ( 10)`	`2% ( 7)`	`0% ( 3)`	`1% ( 4)`	`1% ( 26)`
Unknown		`0% ( 1)`	`1% ( 3)`	`1% ( 4)`	`0% ( 3)`	`0% ( 0)`	`0% ( 11)`
CDR-SB	2335	`0.0/0.0/0.0`	`0.0/0.0/0.0`	`0.5/1.0/2.0`	`1.0/1.5/2.0`	`3.5/4.5/5.0`	`0.0/1.0/2.0`	F=2982 d.f.=4,2301 P<0.001
ADAS 13	2314	`5.67/ 9.00/12.00`	`5.33/ 8.00/11.67`	`9.00/12.00/16.00`	`13.67/18.33/23.33`	`24.00/29.33/34.67`	`8.67/14.00/21.67`	F=786 d.f.=4,2283 P<0.001
MMSE	2334	`29/29/30`	`29/29/30`	`28/29/29`	`26/27/29`	`21/23/25`	`26/28/29`	F=596 d.f.=4,2301 P<0.001

Baseline box plots

dd1 <- subset(dd, VISCODE == "bl" & !is.na(DX.bl), c("RID", "DX.bl", "ADAS13", "CDRSB", 
    "MMSE", "EcogPtMem", "EcogSPMem", "EcogPtTotal", "EcogSPTotal"))
ggplot(dd1, aes(DX.bl, ADAS13)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, MMSE)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, CDRSB)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none")

ggplot(dd1, aes(DX.bl, EcogPtMem)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Self Memory")

ggplot(dd1, aes(DX.bl, EcogSPMem)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Partner Memory")

ggplot(dd1, aes(DX.bl, EcogPtTotal)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Self Total")

ggplot(dd1, aes(DX.bl, EcogSPTotal)) + geom_boxplot(aes(fill = DX.bl), outlier.shape = NA) + 
    geom_jitter(size = 1, position = position_jitter(h = 0)) + theme(legend.position = "none") + 
    ylab("ECog Partner Total")

Baseline summary statistics

cols <- c("ADAS13", "MMSE", "CDRSB", "EcogPtMem", "EcogPtTotal", "EcogSPTotal")
for (cc in cols) {
    dd1$x <- dd1[, cc]
    tab <- with(dd1, Hmisc::summarize(x, by = DX.bl, FUN = summary.default, stat.name = "N"))
    cat("\n### ", label(dd1[, cc]), "\n")
    rownames(tab) <- tab[, 1]
    kable(tab[, -1])
}


###  ADAS 13 

###  MMSE 

###  CDR-SB 

###  Pt ECog - Mem 

###  Pt ECog - Total 

###  SP ECog - Total

Longitudinal plots


\clearpage
\subsection{ ADAS 13 change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $270$&   $-11.00$&   $-2.000$&   $ 0.000$&   $-0.3850$&   $ 2.00$&   $11.00$&   $ 3.43$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $262$&   $-11.00$&   $-3.000$&   $-0.340$&   $-0.5540$&   $ 2.00$&   $11.00$&   $ 3.71$\tabularnewline
   ~~18&   $  4$&   $  2.67$&   $ 4.170$&   $ 5.170$&   $ 5.0000$&   $ 6.00$&   $ 7.00$&   $ 1.82$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $363$&   $-10.00$&   $-2.670$&   $ 0.000$&   $-0.3530$&   $ 2.00$&   $13.30$&   $ 3.53$\tabularnewline
   ~~30&   $ 27$&   $ -4.34$&   $-0.330$&   $ 0.330$&   $ 0.5810$&   $ 1.34$&   $ 7.00$&   $ 2.45$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 56$&   $ -9.33$&   $-2.000$&   $ 0.000$&   $ 0.5120$&   $ 2.25$&   $26.00$&   $ 5.19$\tabularnewline
   ~~42&   $  7$&   $ -6.67$&   $-4.340$&   $ 1.000$&   $ 0.6190$&   $ 5.84$&   $ 7.00$&   $ 5.75$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $163$&   $ -8.00$&   $-3.000$&   $ 0.000$&   $ 0.1920$&   $ 3.00$&   $14.00$&   $ 4.06$\tabularnewline
   ~~54&   $ 20$&   $ -8.33$&   $-2.660$&   $ 0.670$&   $ 0.2010$&   $ 2.75$&   $ 8.00$&   $ 4.22$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 28$&   $ -6.33$&   $-1.420$&   $ 0.000$&   $ 2.1800$&   $ 4.50$&   $17.00$&   $ 5.94$\tabularnewline
   ~~66&   $ 50$&   $ -5.67$&   $-2.580$&   $-0.670$&   $-0.2940$&   $ 1.58$&   $ 9.00$&   $ 3.42$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 62$&   $ -6.67$&   $-1.920$&   $ 0.500$&   $ 1.3700$&   $ 3.33$&   $19.70$&   $ 5.23$\tabularnewline
   ~~78&   $ 43$&   $ -6.33$&   $-2.000$&   $ 1.000$&   $ 1.1900$&   $ 3.66$&   $14.70$&   $ 4.56$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 21$&   $ -7.33$&   $-0.330$&   $ 1.670$&   $ 4.8300$&   $ 5.33$&   $27.30$&   $ 8.66$\tabularnewline
   ~~90&   $ 38$&   $ -6.67$&   $-2.330$&   $ 1.670$&   $ 1.5200$&   $ 4.83$&   $11.00$&   $ 4.75$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 37$&   $ -9.33$&   $-1.670$&   $ 2.330$&   $ 2.3600$&   $ 5.00$&   $19.00$&   $ 6.26$\tabularnewline
   ~~102&   $ 15$&   $ -3.00$&   $ 0.000$&   $ 2.000$&   $ 2.6200$&   $ 6.33$&   $ 8.33$&   $ 3.86$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  5$&   $ -0.67$&   $ 1.330$&   $ 2.670$&   $ 3.0000$&   $ 3.67$&   $ 8.00$&   $ 3.23$\tabularnewline
   ~~114&   $  9$&   $ -5.00$&   $-2.330$&   $-1.330$&   $ 1.7400$&   $ 3.33$&   $19.00$&   $ 7.26$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  9$&   $ -6.00$&   $-2.000$&   $-1.000$&   $ 1.7400$&   $ 3.67$&   $16.00$&   $ 6.98$\tabularnewline
   ~~126&   $  3$&   $  1.67$&   $ 3.840$&   $ 6.000$&   $ 7.1100$&   $ 9.84$&   $13.70$&   $ 6.08$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $429$&   $-12.00$&   $-3.000$&   $ 0.000$&   $ 0.0583$&   $ 3.00$&   $16.00$&   $ 4.38$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $540$&   $-15.00$&   $-3.000$&   $ 0.000$&   $ 0.1490$&   $ 3.00$&   $54.00$&   $ 4.99$\tabularnewline
   ~~18&   $  4$&   $ -1.66$&   $-0.918$&   $ 1.830$&   $ 5.3300$&   $ 8.08$&   $19.30$&   $ 9.69$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $422$&   $-11.00$&   $-2.750$&   $ 0.000$&   $ 1.1500$&   $ 4.00$&   $21.00$&   $ 5.48$\tabularnewline
   ~~30&   $  9$&   $ -4.00$&   $ 0.670$&   $ 6.000$&   $ 5.8500$&   $ 9.67$&   $20.00$&   $ 7.27$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $346$&   $-14.00$&   $-2.000$&   $ 1.000$&   $ 2.1500$&   $ 5.00$&   $49.00$&   $ 7.35$\tabularnewline
   ~~42&   $  3$&   $ -8.00$&   $-4.660$&   $-1.330$&   $-2.3300$&   $ 0.50$&   $ 2.33$&   $ 5.24$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $250$&   $-12.00$&   $-2.000$&   $ 1.000$&   $ 3.4500$&   $ 6.00$&   $55.00$&   $ 9.59$\tabularnewline
   ~~54&   $  6$&   $ -3.67$&   $ 1.330$&   $ 2.660$&   $ 5.0600$&   $ 9.00$&   $16.70$&   $ 7.37$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $122$&   $ -7.00$&   $-1.500$&   $ 2.000$&   $ 4.5900$&   $ 6.25$&   $71.00$&   $11.20$\tabularnewline
   ~~66&   $ 31$&   $ -8.00$&   $-3.160$&   $ 1.330$&   $ 4.0400$&   $ 7.67$&   $30.00$&   $10.00$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 64$&   $ -7.67$&   $-1.670$&   $ 1.000$&   $ 1.9500$&   $ 4.41$&   $21.00$&   $ 5.87$\tabularnewline
   ~~78&   $ 37$&   $ -7.00$&   $-1.670$&   $ 0.330$&   $ 2.8200$&   $ 4.00$&   $38.70$&   $ 8.61$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 52$&   $ -5.33$&   $-1.330$&   $ 1.500$&   $ 3.8600$&   $ 6.84$&   $26.70$&   $ 7.50$\tabularnewline
   ~~90&   $ 41$&   $ -7.67$&   $-2.000$&   $ 2.000$&   $ 2.5200$&   $ 5.67$&   $20.00$&   $ 7.20$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 35$&   $-10.00$&   $-1.670$&   $ 1.330$&   $ 5.0400$&   $ 6.83$&   $39.70$&   $10.60$\tabularnewline
   ~~102&   $ 33$&   $ -8.00$&   $-4.000$&   $ 1.330$&   $ 1.8400$&   $ 4.33$&   $21.00$&   $ 6.42$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 24$&   $ -9.67$&   $-2.750$&   $-0.665$&   $ 2.3600$&   $ 2.83$&   $26.00$&   $ 9.31$\tabularnewline
   ~~114&   $ 14$&   $ -7.33$&   $-1.580$&   $ 0.670$&   $ 1.5500$&   $ 3.75$&   $14.00$&   $ 5.57$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $ 13$&   $-10.00$&   $-3.330$&   $-0.330$&   $ 1.1300$&   $ 2.67$&   $24.00$&   $ 8.36$\tabularnewline
   ~~126&   $  5$&   $-10.70$&   $-1.670$&   $ 8.000$&   $ 7.8000$&   $16.30$&   $27.00$&   $14.80$\tabularnewline
\rowcolor[gray]{.9}   ~~132&   $  4$&   $ -6.00$&   $ 0.248$&   $ 3.830$&   $ 5.6600$&   $ 9.25$&   $21.00$&   $11.30$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $127$&   $-12.00$&   $-1.500$&   $ 2.000$&   $ 2.3800$&   $ 6.50$&   $23.00$&   $ 5.62$\tabularnewline
   ~~12&   $137$&   $-13.00$&   $ 0.000$&   $ 3.670$&   $ 4.5900$&   $ 8.00$&   $27.00$&   $ 6.44$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  2$&   $ -0.33$&   $ 5.090$&   $10.500$&   $10.5000$&   $15.90$&   $21.30$&   $15.30$\tabularnewline
   ~~24&   $ 46$&   $ -5.33$&   $ 3.000$&   $ 7.500$&   $ 9.7000$&   $13.00$&   $36.00$&   $10.20$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  3$&   $ -1.67$&   $ 2.000$&   $ 5.670$&   $ 5.5600$&   $ 9.17$&   $12.70$&   $ 7.17$\tabularnewline
   ~~36&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  1$&   $  4.33$&   $ 4.330$&   $ 4.330$&   $ 4.3300$&   $ 4.33$&   $ 4.33$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  1$&   $  6.67$&   $ 6.670$&   $ 6.670$&   $ 6.6700$&   $ 6.67$&   $ 6.67$&   $$\tabularnewline
   ~~72&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~78&   $  1$&   $  9.00$&   $ 9.000$&   $ 9.000$&   $ 9.0000$&   $ 9.00$&   $ 9.00$&   $$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~90&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~96&   $  1$&   $ 11.00$&   $11.000$&   $11.000$&   $11.0000$&   $11.00$&   $11.00$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~102&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}


\clearpage
\subsection{ MMSE change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $274$&   $ -4$&   $ -1.00$&   $  0.0$&   $ -0.0547$&   $ 1.00$&   $ 4$&   $1.400$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $265$&   $ -8$&   $ -1.00$&   $  0.0$&   $ -0.2190$&   $ 1.00$&   $ 4$&   $1.580$\tabularnewline
   ~~18&   $  4$&   $ -2$&   $ -0.50$&   $  0.5$&   $  0.5000$&   $ 1.50$&   $ 3$&   $2.080$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $370$&   $-24$&   $ -1.00$&   $  0.0$&   $ -0.2190$&   $ 1.00$&   $ 4$&   $1.890$\tabularnewline
   ~~30&   $ 28$&   $ -3$&   $ -1.00$&   $  0.0$&   $ -0.2140$&   $ 1.00$&   $ 2$&   $1.450$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 59$&   $ -9$&   $ -1.00$&   $  0.0$&   $ -0.6270$&   $ 0.00$&   $ 4$&   $1.990$\tabularnewline
   ~~42&   $  7$&   $  0$&   $  0.00$&   $  0.0$&   $  0.5710$&   $ 1.00$&   $ 2$&   $0.787$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $163$&   $-13$&   $ -1.00$&   $  0.0$&   $ -0.3370$&   $ 1.00$&   $ 4$&   $1.960$\tabularnewline
   ~~54&   $ 19$&   $ -2$&   $ -0.50$&   $  0.0$&   $  0.1580$&   $ 1.00$&   $ 3$&   $1.260$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 29$&   $-10$&   $ -1.00$&   $  0.0$&   $ -0.6210$&   $ 0.00$&   $ 3$&   $2.350$\tabularnewline
   ~~66&   $ 50$&   $ -6$&   $ -1.00$&   $  0.0$&   $ -0.1800$&   $ 1.00$&   $ 4$&   $1.860$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 60$&   $ -5$&   $ -1.00$&   $  0.0$&   $ -0.3500$&   $ 0.25$&   $ 4$&   $1.680$\tabularnewline
   ~~78&   $ 43$&   $ -8$&   $ -1.00$&   $  0.0$&   $ -0.5120$&   $ 0.00$&   $ 3$&   $1.840$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 20$&   $ -7$&   $ -3.00$&   $  0.0$&   $ -1.1500$&   $ 0.00$&   $ 3$&   $2.620$\tabularnewline
   ~~90&   $ 39$&   $ -4$&   $ -1.50$&   $  0.0$&   $ -0.5900$&   $ 0.50$&   $ 4$&   $1.650$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 38$&   $-10$&   $ -2.00$&   $  0.0$&   $ -0.8950$&   $ 0.00$&   $ 4$&   $2.280$\tabularnewline
   ~~102&   $ 16$&   $ -5$&   $ -1.25$&   $  0.0$&   $ -0.5000$&   $ 0.00$&   $ 3$&   $1.750$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  6$&   $ -3$&   $ -1.50$&   $  0.0$&   $ -0.5000$&   $ 0.00$&   $ 2$&   $1.760$\tabularnewline
   ~~114&   $ 10$&   $-11$&   $ -2.00$&   $ -1.0$&   $ -2.1000$&   $ 0.00$&   $ 1$&   $3.540$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  8$&   $ -6$&   $ -2.00$&   $  0.0$&   $ -1.1200$&   $ 0.00$&   $ 3$&   $2.950$\tabularnewline
   ~~126&   $  3$&   $ -1$&   $ -1.00$&   $ -1.0$&   $ -0.6670$&   $-0.50$&   $ 0$&   $0.577$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $430$&   $-10$&   $ -2.00$&   $  0.0$&   $ -0.4490$&   $ 1.00$&   $ 5$&   $1.880$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $543$&   $-11$&   $ -2.00$&   $  0.0$&   $ -0.5140$&   $ 1.00$&   $ 6$&   $2.090$\tabularnewline
   ~~18&   $  4$&   $-10$&   $ -4.00$&   $ -1.0$&   $ -2.7500$&   $ 0.25$&   $ 1$&   $4.990$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $429$&   $-12$&   $ -2.00$&   $  0.0$&   $ -0.8900$&   $ 1.00$&   $ 6$&   $2.460$\tabularnewline
   ~~30&   $  9$&   $ -7$&   $ -6.00$&   $ -2.0$&   $ -2.7800$&   $-1.00$&   $ 3$&   $3.460$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $347$&   $-23$&   $ -2.00$&   $ -1.0$&   $ -1.1900$&   $ 1.00$&   $ 6$&   $3.250$\tabularnewline
   ~~42&   $  2$&   $  0$&   $  0.25$&   $  0.5$&   $  0.5000$&   $ 0.75$&   $ 1$&   $0.707$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $253$&   $-20$&   $ -3.00$&   $ -1.0$&   $ -1.6000$&   $ 1.00$&   $ 5$&   $3.830$\tabularnewline
   ~~54&   $  6$&   $ -5$&   $ -5.00$&   $ -3.0$&   $ -2.5000$&   $-0.25$&   $ 1$&   $2.810$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $125$&   $-30$&   $ -3.00$&   $ -1.0$&   $ -1.8700$&   $ 0.00$&   $ 5$&   $4.630$\tabularnewline
   ~~66&   $ 34$&   $-15$&   $ -3.00$&   $ -1.0$&   $ -2.3800$&   $ 1.00$&   $ 4$&   $5.070$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 63$&   $-13$&   $ -2.00$&   $  0.0$&   $ -1.1600$&   $ 0.00$&   $ 5$&   $2.920$\tabularnewline
   ~~78&   $ 40$&   $-16$&   $ -2.00$&   $ -1.0$&   $ -1.5800$&   $ 0.25$&   $ 4$&   $3.840$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 54$&   $-17$&   $ -3.00$&   $ -1.0$&   $ -1.7000$&   $ 1.00$&   $ 5$&   $4.230$\tabularnewline
   ~~90&   $ 44$&   $-20$&   $ -3.25$&   $ -0.5$&   $ -1.9800$&   $ 0.00$&   $ 6$&   $4.400$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 35$&   $-12$&   $ -2.50$&   $ -1.0$&   $ -1.7700$&   $ 0.50$&   $ 2$&   $3.590$\tabularnewline
   ~~102&   $ 34$&   $ -9$&   $ -2.00$&   $ -1.0$&   $ -0.9410$&   $ 0.75$&   $ 5$&   $2.600$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 24$&   $-10$&   $ -2.25$&   $  0.0$&   $ -0.9580$&   $ 1.00$&   $ 2$&   $2.760$\tabularnewline
   ~~114&   $ 14$&   $ -4$&   $ -1.00$&   $ -0.5$&   $ -0.6430$&   $ 0.00$&   $ 4$&   $1.980$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $ 14$&   $ -6$&   $ -1.00$&   $  0.0$&   $ -0.4290$&   $ 1.00$&   $ 3$&   $2.530$\tabularnewline
   ~~126&   $  5$&   $ -9$&   $ -4.00$&   $ -4.0$&   $ -4.0000$&   $-2.00$&   $-1$&   $3.080$\tabularnewline
\rowcolor[gray]{.9}   ~~132&   $  4$&   $ -6$&   $ -2.25$&   $  0.0$&   $ -1.0000$&   $ 1.25$&   $ 2$&   $3.560$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $131$&   $-16$&   $ -3.00$&   $ -1.0$&   $ -1.1800$&   $ 1.00$&   $ 8$&   $3.070$\tabularnewline
   ~~12&   $141$&   $-16$&   $ -4.00$&   $ -2.0$&   $ -2.2500$&   $ 0.00$&   $ 5$&   $3.690$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  3$&   $-19$&   $-14.50$&   $-10.0$&   $-10.7000$&   $-6.50$&   $-3$&   $8.020$\tabularnewline
   ~~24&   $ 48$&   $-14$&   $ -6.00$&   $ -4.0$&   $ -4.1700$&   $-2.00$&   $ 3$&   $4.020$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  3$&   $ -8$&   $ -5.00$&   $ -2.0$&   $ -3.6700$&   $-1.50$&   $-1$&   $3.790$\tabularnewline
   ~~36&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  1$&   $  0$&   $  0.00$&   $  0.0$&   $  0.0000$&   $ 0.00$&   $ 0$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  1$&   $ -4$&   $ -4.00$&   $ -4.0$&   $ -4.0000$&   $-4.00$&   $-4$&   $$\tabularnewline
   ~~72&   $  1$&   $ -3$&   $ -3.00$&   $ -3.0$&   $ -3.0000$&   $-3.00$&   $-3$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~78&   $  1$&   $ -5$&   $ -5.00$&   $ -5.0$&   $ -5.0000$&   $-5.00$&   $-5$&   $$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~90&   $  1$&   $ -5$&   $ -5.00$&   $ -5.0$&   $ -5.0000$&   $-5.00$&   $-5$&   $$\tabularnewline
   ~~96&   $  1$&   $ -8$&   $ -8.00$&   $ -8.0$&   $ -8.0000$&   $-8.00$&   $-8$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~102&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}


\clearpage
\subsection{ CDR-SB change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.0$&   $ 0.000$&   $ 0.00$&   $ 0.0879$&   $ 0.000$&   $ 2.5$&   $0.348$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $263$&   $-1.0$&   $ 0.000$&   $ 0.00$&   $ 0.1250$&   $ 0.000$&   $ 4.0$&   $0.494$\tabularnewline
   ~~18&   $  4$&   $ 0.0$&   $ 0.000$&   $ 0.00$&   $ 0.1250$&   $ 0.125$&   $ 0.5$&   $0.250$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $393$&   $-1.0$&   $ 0.000$&   $ 0.00$&   $ 0.1510$&   $ 0.000$&   $ 5.0$&   $0.561$\tabularnewline
   ~~30&   $ 30$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.2330$&   $ 0.000$&   $ 3.5$&   $0.716$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 54$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.4810$&   $ 0.500$&   $ 5.0$&   $1.130$\tabularnewline
   ~~42&   $  8$&   $ 0.0$&   $ 0.000$&   $ 0.00$&   $ 0.0000$&   $ 0.000$&   $ 0.0$&   $0.000$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $159$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.2140$&   $ 0.000$&   $ 5.0$&   $0.690$\tabularnewline
   ~~54&   $ 19$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.1840$&   $ 0.250$&   $ 1.5$&   $0.448$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 31$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.8230$&   $ 0.500$&   $11.0$&   $2.250$\tabularnewline
   ~~66&   $ 53$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.4060$&   $ 0.500$&   $ 5.5$&   $0.986$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 62$&   $ 0.0$&   $ 0.000$&   $ 0.00$&   $ 0.3230$&   $ 0.000$&   $ 4.5$&   $0.795$\tabularnewline
   ~~78&   $ 50$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.6200$&   $ 0.500$&   $10.0$&   $1.770$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 25$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.8200$&   $ 0.500$&   $ 8.5$&   $1.890$\tabularnewline
   ~~90&   $ 42$&   $ 0.0$&   $ 0.000$&   $ 0.00$&   $ 0.7140$&   $ 0.875$&   $12.0$&   $1.880$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 38$&   $-0.5$&   $ 0.000$&   $ 0.00$&   $ 0.7890$&   $ 1.380$&   $ 4.0$&   $1.290$\tabularnewline
   ~~102&   $ 26$&   $ 0.0$&   $ 0.000$&   $ 0.00$&   $ 1.1000$&   $ 0.500$&   $15.5$&   $3.180$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  8$&   $ 0.0$&   $ 0.000$&   $ 0.50$&   $ 2.5600$&   $ 1.000$&   $17.5$&   $6.050$\tabularnewline
   ~~114&   $ 14$&   $ 0.0$&   $ 0.000$&   $ 0.00$&   $ 1.3200$&   $ 0.875$&   $ 9.0$&   $2.880$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  9$&   $ 0.0$&   $ 0.000$&   $ 0.00$&   $ 0.1110$&   $ 0.000$&   $ 1.0$&   $0.333$\tabularnewline
   ~~126&   $  3$&   $ 0.0$&   $ 0.750$&   $ 1.50$&   $ 1.0000$&   $ 1.500$&   $ 1.5$&   $0.866$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $426$&   $-3.5$&   $-0.500$&   $ 0.00$&   $ 0.1310$&   $ 0.500$&   $ 3.0$&   $0.807$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $544$&   $-3.0$&   $-0.500$&   $ 0.00$&   $ 0.1900$&   $ 0.500$&   $ 5.5$&   $1.020$\tabularnewline
   ~~18&   $  7$&   $-0.5$&   $-0.250$&   $ 0.00$&   $ 1.3600$&   $ 0.750$&   $ 9.0$&   $3.410$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $444$&   $-3.0$&   $-0.500$&   $ 0.00$&   $ 0.5930$&   $ 1.000$&   $11.5$&   $1.650$\tabularnewline
   ~~30&   $ 10$&   $-0.5$&   $ 0.000$&   $ 0.25$&   $ 0.8000$&   $ 1.500$&   $ 3.0$&   $1.250$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $358$&   $-3.5$&   $-0.500$&   $ 0.00$&   $ 0.8560$&   $ 1.500$&   $12.5$&   $2.300$\tabularnewline
   ~~42&   $  3$&   $-1.0$&   $-1.000$&   $-1.00$&   $-0.8330$&   $-0.750$&   $-0.5$&   $0.289$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $257$&   $-3.5$&   $-0.500$&   $ 0.00$&   $ 1.1300$&   $ 2.000$&   $16.0$&   $2.910$\tabularnewline
   ~~54&   $  6$&   $-1.0$&   $ 0.250$&   $ 1.25$&   $ 1.0000$&   $ 1.880$&   $ 2.5$&   $1.300$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $123$&   $-3.0$&   $-0.500$&   $ 0.00$&   $ 0.8860$&   $ 1.250$&   $14.5$&   $2.600$\tabularnewline
   ~~66&   $ 36$&   $-3.0$&   $-0.625$&   $ 0.50$&   $ 1.9900$&   $ 3.500$&   $15.0$&   $4.000$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 65$&   $-3.0$&   $-0.500$&   $ 0.00$&   $ 0.7150$&   $ 1.000$&   $10.0$&   $2.530$\tabularnewline
   ~~78&   $ 42$&   $-2.0$&   $-0.500$&   $ 0.00$&   $ 1.5400$&   $ 1.380$&   $15.5$&   $4.260$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 57$&   $-3.0$&   $-0.500$&   $ 0.50$&   $ 1.6900$&   $ 2.000$&   $17.0$&   $3.770$\tabularnewline
   ~~90&   $ 45$&   $-3.5$&   $-0.500$&   $ 0.00$&   $ 0.6890$&   $ 1.000$&   $12.5$&   $2.900$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 42$&   $-2.5$&   $-0.500$&   $ 0.00$&   $ 1.9200$&   $ 3.120$&   $14.0$&   $3.830$\tabularnewline
   ~~102&   $ 36$&   $-3.5$&   $-1.000$&   $-0.25$&   $ 0.4860$&   $ 1.000$&   $ 9.5$&   $2.460$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 34$&   $-2.5$&   $-0.500$&   $ 0.00$&   $ 1.6800$&   $ 1.500$&   $16.5$&   $4.140$\tabularnewline
   ~~114&   $ 15$&   $-1.0$&   $-0.500$&   $ 0.00$&   $ 1.7300$&   $ 2.250$&   $14.5$&   $3.940$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $ 21$&   $-1.5$&   $-0.500$&   $ 0.00$&   $ 0.4290$&   $ 0.500$&   $10.5$&   $2.450$\tabularnewline
   ~~126&   $  6$&   $-1.0$&   $-0.250$&   $ 1.50$&   $ 3.5000$&   $ 4.000$&   $15.0$&   $5.990$\tabularnewline
\rowcolor[gray]{.9}   ~~132&   $  6$&   $-2.5$&   $-1.250$&   $ 0.50$&   $ 0.8330$&   $ 1.500$&   $ 6.5$&   $3.200$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $131$&   $-2.5$&   $ 0.000$&   $ 0.50$&   $ 0.8130$&   $ 1.500$&   $ 9.0$&   $1.540$\tabularnewline
   ~~12&   $151$&   $-2.0$&   $ 0.000$&   $ 1.00$&   $ 1.8400$&   $ 2.500$&   $11.5$&   $2.410$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  4$&   $ 0.0$&   $ 1.500$&   $ 2.50$&   $ 3.5000$&   $ 4.500$&   $ 9.0$&   $3.870$\tabularnewline
   ~~24&   $ 51$&   $-1.0$&   $ 1.000$&   $ 2.50$&   $ 3.0000$&   $ 5.000$&   $ 8.5$&   $2.580$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  3$&   $ 0.5$&   $ 1.250$&   $ 2.00$&   $ 4.6700$&   $ 6.750$&   $11.5$&   $5.970$\tabularnewline
   ~~36&   $  1$&   $ 1.5$&   $ 1.500$&   $ 1.50$&   $ 1.5000$&   $ 1.500$&   $ 1.5$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  1$&   $ 3.0$&   $ 3.000$&   $ 3.00$&   $ 3.0000$&   $ 3.000$&   $ 3.0$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  3$&   $ 2.0$&   $ 6.500$&   $11.00$&   $ 8.1700$&   $11.200$&   $11.5$&   $5.350$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  1$&   $ 5.0$&   $ 5.000$&   $ 5.00$&   $ 5.0000$&   $ 5.000$&   $ 5.0$&   $$\tabularnewline
   ~~72&   $  1$&   $ 8.5$&   $ 8.500$&   $ 8.50$&   $ 8.5000$&   $ 8.500$&   $ 8.5$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~78&   $  3$&   $ 7.0$&   $ 9.250$&   $11.50$&   $11.0000$&   $13.000$&   $14.5$&   $3.770$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~90&   $  1$&   $ 4.0$&   $ 4.000$&   $ 4.00$&   $ 4.0000$&   $ 4.000$&   $ 4.0$&   $$\tabularnewline
   ~~96&   $  1$&   $11.0$&   $11.000$&   $11.00$&   $11.0000$&   $11.000$&   $11.0$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~102&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}


\clearpage
\subsection{ Pt ECog - Mem change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.5000$&   $-0.2500$&   $ 0.0000$&   $ 0.03030$&   $ 0.2500$&   $ 1.6200$&   $0.431$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $267$&   $-1.3800$&   $-0.2500$&   $ 0.0000$&   $ 0.01890$&   $ 0.2500$&   $ 1.6200$&   $0.418$\tabularnewline
   ~~18&   $  4$&   $-1.0000$&   $-0.3440$&   $-0.0625$&   $ 0.12500$&   $ 0.4060$&   $ 1.6200$&   $1.090$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $402$&   $-2.0000$&   $-0.2500$&   $ 0.0000$&   $ 0.02230$&   $ 0.2500$&   $ 1.7500$&   $0.444$\tabularnewline
   ~~30&   $ 31$&   $-0.6250$&   $-0.3750$&   $-0.1250$&   $-0.10100$&   $ 0.1250$&   $ 0.6250$&   $0.342$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 58$&   $-0.5890$&   $-0.2500$&   $ 0.0000$&   $ 0.03730$&   $ 0.2190$&   $ 1.2500$&   $0.359$\tabularnewline
   ~~42&   $  8$&   $-0.8750$&   $-0.4060$&   $-0.1160$&   $-0.25800$&   $ 0.0000$&   $ 0.0000$&   $0.330$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $165$&   $-1.3800$&   $-0.2500$&   $ 0.0000$&   $ 0.03800$&   $ 0.3750$&   $ 2.1200$&   $0.501$\tabularnewline
   ~~54&   $ 21$&   $-1.4300$&   $-0.0357$&   $ 0.1250$&   $ 0.20400$&   $ 0.6250$&   $ 1.3800$&   $0.663$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 31$&   $-1.0000$&   $-0.0625$&   $ 0.1250$&   $ 0.14300$&   $ 0.3750$&   $ 1.0000$&   $0.426$\tabularnewline
   ~~66&   $ 53$&   $-1.0000$&   $-0.1250$&   $ 0.0893$&   $ 0.11600$&   $ 0.3750$&   $ 1.2500$&   $0.464$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 63$&   $-0.7500$&   $-0.1250$&   $ 0.1250$&   $ 0.16800$&   $ 0.5000$&   $ 1.6200$&   $0.494$\tabularnewline
   ~~78&   $ 50$&   $-1.3200$&   $-0.1150$&   $ 0.1070$&   $ 0.14400$&   $ 0.5000$&   $ 1.6200$&   $0.585$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 26$&   $-1.5000$&   $-0.2500$&   $ 0.2500$&   $ 0.18500$&   $ 0.7190$&   $ 1.8200$&   $0.763$\tabularnewline
   ~~90&   $ 42$&   $-0.7140$&   $-0.1250$&   $ 0.0000$&   $ 0.11500$&   $ 0.2500$&   $ 1.5000$&   $0.489$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 41$&   $-1.1200$&   $-0.1250$&   $ 0.1250$&   $ 0.27200$&   $ 0.6250$&   $ 1.8600$&   $0.640$\tabularnewline
   ~~102&   $ 25$&   $-0.5000$&   $ 0.0000$&   $ 0.2500$&   $ 0.39000$&   $ 0.5000$&   $ 2.2500$&   $0.734$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  7$&   $-0.3750$&   $-0.2500$&   $ 0.0000$&   $ 0.07140$&   $ 0.3750$&   $ 0.6250$&   $0.394$\tabularnewline
   ~~114&   $ 13$&   $-0.3750$&   $-0.0893$&   $ 0.1250$&   $ 0.20100$&   $ 0.3210$&   $ 1.3800$&   $0.477$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  9$&   $-0.7500$&   $-0.1250$&   $ 0.1250$&   $ 0.18100$&   $ 0.7500$&   $ 0.8750$&   $0.556$\tabularnewline
   ~~126&   $  3$&   $-0.1250$&   $ 0.0000$&   $ 0.1250$&   $ 0.37500$&   $ 0.6250$&   $ 1.1200$&   $0.661$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $428$&   $-2.1200$&   $-0.3750$&   $-0.1250$&   $-0.10400$&   $ 0.2500$&   $ 1.6200$&   $0.539$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $548$&   $-2.2500$&   $-0.3750$&   $ 0.0000$&   $-0.05960$&   $ 0.2540$&   $ 1.7500$&   $0.607$\tabularnewline
   ~~18&   $  7$&   $-1.2500$&   $-0.5000$&   $-0.1790$&   $-0.15100$&   $ 0.2500$&   $ 0.8750$&   $0.701$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $443$&   $-2.8800$&   $-0.3750$&   $ 0.0000$&   $-0.03300$&   $ 0.2500$&   $ 2.5000$&   $0.645$\tabularnewline
   ~~30&   $ 10$&   $-0.7500$&   $ 0.0625$&   $ 0.3750$&   $ 0.38000$&   $ 0.7190$&   $ 1.2500$&   $0.590$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $354$&   $-2.3800$&   $-0.3750$&   $ 0.0000$&   $-0.02910$&   $ 0.3750$&   $ 2.5000$&   $0.632$\tabularnewline
   ~~42&   $  3$&   $-1.3800$&   $-1.0000$&   $-0.6250$&   $-0.66700$&   $-0.3120$&   $ 0.0000$&   $0.688$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $249$&   $-2.5000$&   $-0.5000$&   $-0.1250$&   $-0.09080$&   $ 0.3750$&   $ 2.3600$&   $0.727$\tabularnewline
   ~~54&   $  6$&   $-0.6610$&   $-0.2500$&   $-0.1880$&   $-0.19300$&   $-0.0312$&   $ 0.1250$&   $0.271$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $123$&   $-1.5000$&   $-0.3750$&   $ 0.0000$&   $ 0.01800$&   $ 0.5000$&   $ 1.3800$&   $0.600$\tabularnewline
   ~~66&   $ 33$&   $-1.2500$&   $-0.5000$&   $-0.1250$&   $-0.02180$&   $ 0.3750$&   $ 1.7500$&   $0.721$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 66$&   $-1.7500$&   $-0.3440$&   $ 0.0000$&   $ 0.07360$&   $ 0.4690$&   $ 1.7500$&   $0.716$\tabularnewline
   ~~78&   $ 38$&   $-2.1200$&   $-0.2500$&   $-0.1250$&   $-0.02540$&   $ 0.2500$&   $ 2.0000$&   $0.694$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 56$&   $-2.3800$&   $-0.3750$&   $-0.1250$&   $-0.07060$&   $ 0.2500$&   $ 1.6200$&   $0.714$\tabularnewline
   ~~90&   $ 45$&   $-1.3800$&   $-0.3040$&   $-0.1250$&   $-0.05320$&   $ 0.2500$&   $ 2.2100$&   $0.671$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 41$&   $-2.5000$&   $-0.5000$&   $-0.2500$&   $-0.18900$&   $ 0.2500$&   $ 1.6200$&   $0.691$\tabularnewline
   ~~102&   $ 36$&   $-2.2500$&   $-0.6250$&   $-0.1250$&   $-0.22200$&   $ 0.1560$&   $ 1.2500$&   $0.692$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 33$&   $-2.2500$&   $-0.5000$&   $-0.1250$&   $-0.08080$&   $ 0.2500$&   $ 1.8800$&   $0.877$\tabularnewline
   ~~114&   $ 15$&   $-1.0000$&   $-0.1880$&   $ 0.3750$&   $ 0.24200$&   $ 0.7500$&   $ 1.2500$&   $0.659$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $ 22$&   $-1.8800$&   $-0.5000$&   $-0.0982$&   $-0.00893$&   $ 0.2500$&   $ 1.6200$&   $0.825$\tabularnewline
   ~~126&   $  5$&   $-0.5000$&   $-0.3750$&   $-0.3750$&   $-0.22900$&   $-0.1430$&   $ 0.2500$&   $0.297$\tabularnewline
\rowcolor[gray]{.9}   ~~132&   $  6$&   $-1.5000$&   $-0.3750$&   $-0.3120$&   $-0.00298$&   $ 0.5800$&   $ 1.6200$&   $1.090$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $124$&   $-1.8800$&   $-0.4060$&   $ 0.0000$&   $-0.05920$&   $ 0.3750$&   $ 1.7500$&   $0.725$\tabularnewline
   ~~12&   $129$&   $-2.0000$&   $-0.5000$&   $-0.0357$&   $-0.12900$&   $ 0.3750$&   $ 2.0000$&   $0.737$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  2$&   $-1.1000$&   $-0.8250$&   $-0.5500$&   $-0.55000$&   $-0.2750$&   $ 0.0000$&   $0.778$\tabularnewline
   ~~24&   $ 39$&   $-1.7500$&   $-0.5000$&   $-0.1250$&   $-0.11700$&   $ 0.2500$&   $ 2.1200$&   $0.735$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  3$&   $-0.5000$&   $-0.2860$&   $-0.0714$&   $ 0.01790$&   $ 0.2770$&   $ 0.6250$&   $0.568$\tabularnewline
   ~~36&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  1$&   $-0.8750$&   $-0.8750$&   $-0.8750$&   $-0.87500$&   $-0.8750$&   $-0.8750$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  1$&   $-0.0357$&   $-0.0357$&   $-0.0357$&   $-0.03570$&   $-0.0357$&   $-0.0357$&   $$\tabularnewline
   ~~72&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~78&   $  1$&   $-0.8750$&   $-0.8750$&   $-0.8750$&   $-0.87500$&   $-0.8750$&   $-0.8750$&   $$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~90&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~96&   $  1$&   $-1.6200$&   $-1.6200$&   $-1.6200$&   $-1.62000$&   $-1.6200$&   $-1.6200$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~102&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}


\clearpage
\subsection{ SP ECog - Mem change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $263$&   $-1.380$&   $-0.1250$&   $ 0.0000$&   $ 0.01720$&   $ 0.1250$&   $1.6200$&   $0.361$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $261$&   $-1.500$&   $-0.1250$&   $ 0.0000$&   $ 0.03970$&   $ 0.2500$&   $2.1200$&   $0.407$\tabularnewline
   ~~18&   $  4$&   $-0.714$&   $-0.3660$&   $-0.0625$&   $-0.08480$&   $ 0.2190$&   $0.5000$&   $0.519$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $384$&   $-1.500$&   $-0.1250$&   $ 0.0000$&   $ 0.04880$&   $ 0.2500$&   $2.1200$&   $0.424$\tabularnewline
   ~~30&   $ 29$&   $-0.375$&   $ 0.0000$&   $ 0.0000$&   $ 0.12100$&   $ 0.1250$&   $2.1200$&   $0.431$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 54$&   $-1.380$&   $-0.2190$&   $ 0.0000$&   $ 0.13500$&   $ 0.2880$&   $2.1200$&   $0.580$\tabularnewline
   ~~42&   $  8$&   $-0.714$&   $-0.0625$&   $ 0.0000$&   $-0.03570$&   $ 0.0625$&   $0.4290$&   $0.340$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $156$&   $-1.250$&   $-0.1290$&   $ 0.0000$&   $ 0.10000$&   $ 0.2500$&   $2.1200$&   $0.483$\tabularnewline
   ~~54&   $ 21$&   $-0.500$&   $ 0.0000$&   $ 0.1250$&   $ 0.18000$&   $ 0.3750$&   $1.0400$&   $0.432$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 30$&   $-0.750$&   $-0.2500$&   $ 0.0000$&   $ 0.18800$&   $ 0.3750$&   $2.4600$&   $0.713$\tabularnewline
   ~~66&   $ 51$&   $-0.625$&   $ 0.0000$&   $ 0.1250$&   $ 0.19800$&   $ 0.4380$&   $1.5000$&   $0.508$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 62$&   $-1.500$&   $-0.1250$&   $ 0.0000$&   $ 0.23000$&   $ 0.4690$&   $2.2500$&   $0.650$\tabularnewline
   ~~78&   $ 51$&   $-2.380$&   $-0.1250$&   $ 0.1250$&   $ 0.17700$&   $ 0.3750$&   $2.7500$&   $0.788$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 25$&   $-0.750$&   $-0.2500$&   $ 0.0000$&   $ 0.32000$&   $ 0.5000$&   $2.7500$&   $0.879$\tabularnewline
   ~~90&   $ 41$&   $-0.589$&   $-0.1250$&   $ 0.1250$&   $ 0.31800$&   $ 0.6250$&   $2.2500$&   $0.613$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 39$&   $-1.380$&   $-0.2500$&   $ 0.0000$&   $ 0.24600$&   $ 0.5000$&   $3.0000$&   $0.836$\tabularnewline
   ~~102&   $ 23$&   $-0.500$&   $ 0.0000$&   $ 0.1250$&   $ 0.51600$&   $ 1.1200$&   $3.0000$&   $0.857$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  8$&   $-0.375$&   $-0.0312$&   $ 0.0625$&   $ 0.51600$&   $ 0.7500$&   $2.7500$&   $1.020$\tabularnewline
   ~~114&   $ 14$&   $-0.500$&   $-0.0670$&   $ 0.3750$&   $ 0.65700$&   $ 0.9380$&   $2.7500$&   $1.020$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  9$&   $-0.625$&   $ 0.0000$&   $ 0.0000$&   $ 0.33300$&   $ 0.5000$&   $2.1200$&   $0.850$\tabularnewline
   ~~126&   $  3$&   $ 0.000$&   $ 0.6670$&   $ 1.3300$&   $ 0.90300$&   $ 1.3500$&   $1.3800$&   $0.782$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $424$&   $-1.880$&   $-0.2500$&   $ 0.0000$&   $ 0.00345$&   $ 0.3750$&   $2.1200$&   $0.561$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $543$&   $-2.750$&   $-0.2500$&   $ 0.0000$&   $ 0.01320$&   $ 0.3040$&   $2.2500$&   $0.584$\tabularnewline
   ~~18&   $  7$&   $-1.750$&   $-0.1960$&   $ 0.0000$&   $-0.23500$&   $ 0.1250$&   $0.2500$&   $0.693$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $444$&   $-1.880$&   $-0.2500$&   $ 0.0000$&   $ 0.09900$&   $ 0.5000$&   $2.1200$&   $0.643$\tabularnewline
   ~~30&   $ 11$&   $-1.750$&   $-0.1340$&   $ 0.0000$&   $ 0.17000$&   $ 0.4380$&   $2.1200$&   $0.960$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $351$&   $-2.250$&   $-0.2500$&   $ 0.1250$&   $ 0.16200$&   $ 0.5000$&   $2.1400$&   $0.715$\tabularnewline
   ~~42&   $  3$&   $-0.625$&   $-0.4380$&   $-0.2500$&   $-0.27600$&   $-0.1010$&   $0.0476$&   $0.337$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $245$&   $-1.750$&   $-0.2500$&   $ 0.1250$&   $ 0.21600$&   $ 0.5000$&   $2.8800$&   $0.714$\tabularnewline
   ~~54&   $  6$&   $-0.125$&   $ 0.0625$&   $ 0.5000$&   $ 0.58300$&   $ 0.9380$&   $1.6200$&   $0.669$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $119$&   $-1.620$&   $-0.1790$&   $ 0.1250$&   $ 0.26600$&   $ 0.6250$&   $2.5000$&   $0.797$\tabularnewline
   ~~66&   $ 37$&   $-0.875$&   $-0.1250$&   $ 0.1250$&   $ 0.24400$&   $ 0.5000$&   $1.6200$&   $0.603$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 64$&   $-1.620$&   $-0.1250$&   $ 0.1250$&   $ 0.24900$&   $ 0.6250$&   $2.2900$&   $0.704$\tabularnewline
   ~~78&   $ 43$&   $-1.120$&   $-0.3750$&   $ 0.0000$&   $ 0.09980$&   $ 0.4380$&   $2.0000$&   $0.755$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 58$&   $-1.120$&   $-0.1250$&   $ 0.1250$&   $ 0.38400$&   $ 0.9790$&   $2.5000$&   $0.825$\tabularnewline
   ~~90&   $ 46$&   $-1.250$&   $-0.4690$&   $ 0.0000$&   $ 0.10700$&   $ 0.5000$&   $2.1700$&   $0.761$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 41$&   $-1.250$&   $-0.1250$&   $ 0.3750$&   $ 0.37400$&   $ 0.7500$&   $2.3800$&   $0.726$\tabularnewline
   ~~102&   $ 35$&   $-2.000$&   $-0.3750$&   $ 0.0000$&   $ 0.07450$&   $ 0.5620$&   $2.0000$&   $0.818$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 36$&   $-0.625$&   $-0.2500$&   $ 0.1250$&   $ 0.35400$&   $ 0.7500$&   $2.5000$&   $0.814$\tabularnewline
   ~~114&   $ 15$&   $-0.857$&   $-0.0625$&   $ 0.5000$&   $ 0.34000$&   $ 0.7500$&   $1.6200$&   $0.655$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $ 21$&   $-0.500$&   $-0.2500$&   $ 0.0000$&   $ 0.21700$&   $ 0.6250$&   $1.5000$&   $0.604$\tabularnewline
   ~~126&   $  6$&   $-0.500$&   $ 0.0938$&   $ 0.8120$&   $ 0.64600$&   $ 1.0600$&   $1.7500$&   $0.827$\tabularnewline
\rowcolor[gray]{.9}   ~~132&   $  6$&   $-0.375$&   $-0.2190$&   $-0.0625$&   $ 0.50000$&   $ 0.9380$&   $2.5000$&   $1.140$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $130$&   $-2.750$&   $-0.2500$&   $ 0.0000$&   $ 0.04210$&   $ 0.4790$&   $1.6200$&   $0.616$\tabularnewline
   ~~12&   $149$&   $-1.000$&   $ 0.0000$&   $ 0.1250$&   $ 0.22300$&   $ 0.5000$&   $2.1200$&   $0.497$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  4$&   $-1.620$&   $-0.5940$&   $ 0.1250$&   $-0.18800$&   $ 0.5310$&   $0.6250$&   $1.030$\tabularnewline
   ~~24&   $ 51$&   $-1.750$&   $-0.0625$&   $ 0.1250$&   $ 0.14700$&   $ 0.3750$&   $1.7500$&   $0.644$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  4$&   $ 0.000$&   $ 0.1880$&   $ 0.2500$&   $ 0.43800$&   $ 0.5000$&   $1.2500$&   $0.554$\tabularnewline
   ~~36&   $  1$&   $ 0.000$&   $ 0.0000$&   $ 0.0000$&   $ 0.00000$&   $ 0.0000$&   $0.0000$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  1$&   $ 0.000$&   $ 0.0000$&   $ 0.0000$&   $ 0.00000$&   $ 0.0000$&   $0.0000$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  3$&   $ 0.125$&   $ 0.6250$&   $ 1.1200$&   $ 1.12000$&   $ 1.6200$&   $2.1200$&   $1.000$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  1$&   $ 0.000$&   $ 0.0000$&   $ 0.0000$&   $ 0.00000$&   $ 0.0000$&   $0.0000$&   $$\tabularnewline
   ~~72&   $  1$&   $ 1.120$&   $ 1.1200$&   $ 1.1200$&   $ 1.12000$&   $ 1.1200$&   $1.1200$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~78&   $  3$&   $ 0.000$&   $ 0.9110$&   $ 1.8200$&   $ 1.32000$&   $ 1.9700$&   $2.1200$&   $1.150$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~90&   $  1$&   $ 0.000$&   $ 0.0000$&   $ 0.0000$&   $ 0.00000$&   $ 0.0000$&   $0.0000$&   $$\tabularnewline
   ~~96&   $  1$&   $ 2.000$&   $ 2.0000$&   $ 2.0000$&   $ 2.00000$&   $ 2.0000$&   $2.0000$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~102&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}


\clearpage
\subsection{ Pt ECog - Total change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $273$&   $-1.1400$&   $-0.103000$&   $ 0.00000$&   $ 0.01780$&   $ 0.1280$&   $ 0.8210$&   $0.253$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $267$&   $-0.7510$&   $-0.103000$&   $ 0.00000$&   $ 0.02730$&   $ 0.1280$&   $ 1.4600$&   $0.248$\tabularnewline
   ~~18&   $  4$&   $-0.7890$&   $-0.355000$&   $-0.10500$&   $-0.01970$&   $ 0.2300$&   $ 0.9210$&   $0.710$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $402$&   $-1.3400$&   $-0.103000$&   $ 0.00000$&   $ 0.02110$&   $ 0.1320$&   $ 1.1800$&   $0.294$\tabularnewline
   ~~30&   $ 31$&   $-0.6580$&   $-0.254000$&   $-0.07890$&   $-0.08740$&   $ 0.0395$&   $ 0.4210$&   $0.230$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 58$&   $-0.5260$&   $-0.078900$&   $ 0.00000$&   $ 0.06850$&   $ 0.1780$&   $ 1.2400$&   $0.279$\tabularnewline
   ~~42&   $  8$&   $-0.6580$&   $-0.255000$&   $-0.06030$&   $-0.17200$&   $-0.0260$&   $ 0.1840$&   $0.299$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $166$&   $-0.9850$&   $-0.103000$&   $ 0.02560$&   $ 0.04460$&   $ 0.1730$&   $ 1.7200$&   $0.312$\tabularnewline
   ~~54&   $ 21$&   $-0.6950$&   $-0.087700$&   $ 0.09850$&   $ 0.11300$&   $ 0.2720$&   $ 0.8240$&   $0.365$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 31$&   $-0.7250$&   $-0.068500$&   $ 0.13200$&   $ 0.10500$&   $ 0.3080$&   $ 0.6940$&   $0.317$\tabularnewline
   ~~66&   $ 53$&   $-0.3540$&   $ 0.004050$&   $ 0.09530$&   $ 0.14200$&   $ 0.2110$&   $ 0.9300$&   $0.253$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 63$&   $-1.0100$&   $-0.044900$&   $ 0.10700$&   $ 0.09230$&   $ 0.2190$&   $ 1.0300$&   $0.331$\tabularnewline
   ~~78&   $ 50$&   $-0.5750$&   $-0.067900$&   $ 0.06080$&   $ 0.11500$&   $ 0.2700$&   $ 1.3000$&   $0.345$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 26$&   $-0.7840$&   $-0.092100$&   $ 0.15600$&   $ 0.12900$&   $ 0.3240$&   $ 1.0500$&   $0.423$\tabularnewline
   ~~90&   $ 42$&   $-0.4210$&   $-0.019200$&   $ 0.08400$&   $ 0.15800$&   $ 0.2370$&   $ 1.1600$&   $0.319$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 41$&   $-1.1100$&   $-0.036000$&   $ 0.11100$&   $ 0.14300$&   $ 0.2380$&   $ 1.1100$&   $0.369$\tabularnewline
   ~~102&   $ 25$&   $-0.6160$&   $ 0.002700$&   $ 0.13100$&   $ 0.39100$&   $ 0.5000$&   $ 2.6400$&   $0.717$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  7$&   $-0.2540$&   $-0.106000$&   $ 0.13800$&   $ 0.11100$&   $ 0.3280$&   $ 0.4450$&   $0.279$\tabularnewline
   ~~114&   $ 13$&   $-0.0236$&   $ 0.000675$&   $ 0.08390$&   $ 0.20300$&   $ 0.3180$&   $ 0.8300$&   $0.281$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  9$&   $-0.3100$&   $-0.065500$&   $ 0.08100$&   $ 0.09120$&   $ 0.2110$&   $ 0.5370$&   $0.247$\tabularnewline
   ~~126&   $  3$&   $ 0.0000$&   $ 0.026700$&   $ 0.05330$&   $ 0.31500$&   $ 0.4720$&   $ 0.8910$&   $0.500$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $430$&   $-2.0800$&   $-0.219000$&   $-0.02630$&   $-0.03500$&   $ 0.1500$&   $ 1.5900$&   $0.376$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $551$&   $-1.6900$&   $-0.231000$&   $-0.02560$&   $-0.02240$&   $ 0.1840$&   $ 1.6700$&   $0.397$\tabularnewline
   ~~18&   $  7$&   $-0.7370$&   $-0.248000$&   $ 0.23700$&   $ 0.01550$&   $ 0.3290$&   $ 0.4470$&   $0.445$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $445$&   $-1.6900$&   $-0.205000$&   $ 0.00000$&   $ 0.02560$&   $ 0.2370$&   $ 1.7400$&   $0.449$\tabularnewline
   ~~30&   $ 10$&   $-0.5000$&   $ 0.059200$&   $ 0.14300$&   $ 0.17200$&   $ 0.3770$&   $ 0.7630$&   $0.350$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $350$&   $-1.7300$&   $-0.198000$&   $ 0.02560$&   $ 0.04720$&   $ 0.2920$&   $ 1.9900$&   $0.451$\tabularnewline
   ~~42&   $  3$&   $-0.6580$&   $-0.438000$&   $-0.21800$&   $-0.27400$&   $-0.0825$&   $ 0.0526$&   $0.359$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $248$&   $-2.3100$&   $-0.246000$&   $ 0.03910$&   $ 0.03820$&   $ 0.3330$&   $ 2.7100$&   $0.533$\tabularnewline
   ~~54&   $  6$&   $-0.3330$&   $ 0.015500$&   $ 0.11100$&   $ 0.18000$&   $ 0.2300$&   $ 0.9400$&   $0.422$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $122$&   $-1.2100$&   $-0.157000$&   $ 0.03850$&   $ 0.06700$&   $ 0.3280$&   $ 1.1300$&   $0.435$\tabularnewline
   ~~66&   $ 32$&   $-1.0900$&   $-0.200000$&   $-0.01010$&   $ 0.07280$&   $ 0.2130$&   $ 1.4800$&   $0.503$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 66$&   $-0.9710$&   $-0.143000$&   $ 0.09420$&   $ 0.09120$&   $ 0.3790$&   $ 0.8780$&   $0.427$\tabularnewline
   ~~78&   $ 38$&   $-1.1300$&   $-0.187000$&   $-0.01250$&   $ 0.04180$&   $ 0.1600$&   $ 1.6000$&   $0.521$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 56$&   $-1.0700$&   $-0.199000$&   $ 0.00742$&   $ 0.03030$&   $ 0.2090$&   $ 1.3800$&   $0.481$\tabularnewline
   ~~90&   $ 45$&   $-1.0900$&   $-0.089600$&   $ 0.02850$&   $ 0.07000$&   $ 0.2680$&   $ 2.5900$&   $0.528$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 41$&   $-1.0900$&   $-0.251000$&   $-0.10100$&   $-0.00312$&   $ 0.1730$&   $ 1.4100$&   $0.464$\tabularnewline
   ~~102&   $ 36$&   $-0.8740$&   $-0.341000$&   $ 0.05110$&   $-0.04090$&   $ 0.1530$&   $ 0.6150$&   $0.367$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 33$&   $-0.8620$&   $-0.237000$&   $ 0.00925$&   $ 0.05880$&   $ 0.3040$&   $ 1.4700$&   $0.515$\tabularnewline
   ~~114&   $ 15$&   $-0.8840$&   $-0.098200$&   $ 0.18000$&   $ 0.21000$&   $ 0.7140$&   $ 1.0200$&   $0.557$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $ 22$&   $-1.3700$&   $-0.233000$&   $ 0.08130$&   $ 0.04980$&   $ 0.4010$&   $ 1.3800$&   $0.570$\tabularnewline
   ~~126&   $  5$&   $-0.8180$&   $ 0.079600$&   $ 0.16300$&   $ 0.00836$&   $ 0.1700$&   $ 0.4470$&   $0.483$\tabularnewline
\rowcolor[gray]{.9}   ~~132&   $  6$&   $-1.3900$&   $-0.324000$&   $-0.23100$&   $-0.25100$&   $-0.1540$&   $ 0.8300$&   $0.706$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $120$&   $-1.6900$&   $-0.298000$&   $ 0.02320$&   $-0.01190$&   $ 0.2840$&   $ 1.5100$&   $0.554$\tabularnewline
   ~~12&   $127$&   $-1.3800$&   $-0.346000$&   $-0.00427$&   $ 0.00309$&   $ 0.2930$&   $ 2.1000$&   $0.551$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  2$&   $-1.1000$&   $-0.828000$&   $-0.56100$&   $-0.56100$&   $-0.2940$&   $-0.0263$&   $0.756$\tabularnewline
   ~~24&   $ 39$&   $-1.4300$&   $-0.169000$&   $ 0.04500$&   $ 0.08480$&   $ 0.4080$&   $ 2.3200$&   $0.616$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  3$&   $-0.0628$&   $ 0.134000$&   $ 0.33100$&   $ 0.27300$&   $ 0.4420$&   $ 0.5530$&   $0.312$\tabularnewline
   ~~36&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  1$&   $-0.5430$&   $-0.543000$&   $-0.54300$&   $-0.54300$&   $-0.5430$&   $-0.5430$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  1$&   $ 0.0535$&   $ 0.053500$&   $ 0.05350$&   $ 0.05350$&   $ 0.0535$&   $ 0.0535$&   $$\tabularnewline
   ~~72&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~78&   $  1$&   $-0.1910$&   $-0.191000$&   $-0.19100$&   $-0.19100$&   $-0.1910$&   $-0.1910$&   $$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~90&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~96&   $  1$&   $-0.6130$&   $-0.613000$&   $-0.61300$&   $-0.61300$&   $-0.6130$&   $-0.6130$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~102&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}


\clearpage
\subsection{ SP ECog - Total change from baseline}

%latex.default(tab[, -(1:2)], file = "", rowlabel = "Month", rowname = tab[,     1], rgroup = unique(tab[, 2]), n.rgroup = table(tab[, 2]),     digits = 3, where = "h!", rownamesTexCmd = rcmd, label = paste("long",         oc, sep = ""))%
\begin{table}[h!]
\begin{center}
\begin{tabular}{lrrrrrrrr}
\hline\hline
\multicolumn{1}{l}{Month}&\multicolumn{1}{c}{N}&\multicolumn{1}{c}{Min.}&\multicolumn{1}{c}{Q.1}&\multicolumn{1}{c}{Median}&\multicolumn{1}{c}{Mean}&\multicolumn{1}{c}{Q.3}&\multicolumn{1}{c}{Max.}&\multicolumn{1}{c}{SD}\tabularnewline
\hline
{\bfseries CN}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $265$&   $-0.8790$&   $-0.051300$&   $ 0.000000$&   $ 0.00909$&   $ 0.0769$&   $ 0.8460$&   $0.193$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $261$&   $-1.2100$&   $-0.036500$&   $ 0.000000$&   $ 0.03840$&   $ 0.0978$&   $ 1.6200$&   $0.257$\tabularnewline
   ~~18&   $  4$&   $-0.4060$&   $-0.240000$&   $-0.078900$&   $-0.06630$&   $ 0.0944$&   $ 0.2990$&   $0.301$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $384$&   $-1.1300$&   $-0.051600$&   $ 0.000000$&   $ 0.04280$&   $ 0.1030$&   $ 2.0000$&   $0.277$\tabularnewline
   ~~30&   $ 29$&   $-0.3160$&   $ 0.000000$&   $ 0.000000$&   $ 0.04390$&   $ 0.0555$&   $ 1.1100$&   $0.239$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $ 54$&   $-1.3300$&   $-0.047600$&   $ 0.051300$&   $ 0.14000$&   $ 0.1830$&   $ 2.0500$&   $0.487$\tabularnewline
   ~~42&   $  8$&   $-0.4320$&   $ 0.000000$&   $ 0.081000$&   $ 0.05070$&   $ 0.2150$&   $ 0.2370$&   $0.222$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $157$&   $-1.0500$&   $-0.052600$&   $ 0.000000$&   $ 0.07390$&   $ 0.1030$&   $ 1.6800$&   $0.335$\tabularnewline
   ~~54&   $ 21$&   $-0.3180$&   $-0.024300$&   $ 0.083300$&   $ 0.17100$&   $ 0.3030$&   $ 0.8470$&   $0.303$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $ 30$&   $-0.5400$&   $-0.075400$&   $ 0.039800$&   $ 0.20900$&   $ 0.2050$&   $ 2.5400$&   $0.647$\tabularnewline
   ~~66&   $ 51$&   $-0.5640$&   $ 0.000000$&   $ 0.032100$&   $ 0.13900$&   $ 0.2180$&   $ 1.4300$&   $0.358$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 61$&   $-0.9940$&   $-0.051300$&   $ 0.052600$&   $ 0.18200$&   $ 0.2910$&   $ 2.5200$&   $0.504$\tabularnewline
   ~~78&   $ 51$&   $-1.5400$&   $-0.048500$&   $ 0.052600$&   $ 0.20200$&   $ 0.2360$&   $ 2.9500$&   $0.636$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 25$&   $-0.6460$&   $-0.103000$&   $ 0.000000$&   $ 0.27800$&   $ 0.2910$&   $ 2.4000$&   $0.757$\tabularnewline
   ~~90&   $ 41$&   $-0.5640$&   $ 0.000000$&   $ 0.090500$&   $ 0.23000$&   $ 0.2630$&   $ 2.3000$&   $0.527$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 40$&   $-0.9940$&   $-0.063400$&   $ 0.000337$&   $ 0.18200$&   $ 0.1680$&   $ 2.4700$&   $0.574$\tabularnewline
   ~~102&   $ 23$&   $-0.1220$&   $ 0.000000$&   $ 0.081600$&   $ 0.37800$&   $ 0.6070$&   $ 2.4500$&   $0.592$\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $  8$&   $-0.1050$&   $-0.018200$&   $ 0.134000$&   $ 0.48000$&   $ 0.3910$&   $ 2.8700$&   $0.993$\tabularnewline
   ~~114&   $ 14$&   $-0.5640$&   $-0.024600$&   $ 0.195000$&   $ 0.52500$&   $ 0.5130$&   $ 2.7400$&   $0.983$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $  9$&   $-0.4590$&   $-0.128000$&   $ 0.000000$&   $ 0.06110$&   $ 0.2670$&   $ 0.7270$&   $0.339$\tabularnewline
   ~~126&   $  3$&   $ 0.0000$&   $ 0.353000$&   $ 0.707000$&   $ 0.62200$&   $ 0.9320$&   $ 1.1600$&   $0.584$\tabularnewline
\hline
{\bfseries MCI}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~6&   $426$&   $-1.4600$&   $-0.167000$&   $ 0.020600$&   $ 0.05150$&   $ 0.2540$&   $ 1.9900$&   $0.411$\tabularnewline
\rowcolor[gray]{.9}   ~~12&   $543$&   $-2.0400$&   $-0.130000$&   $ 0.051300$&   $ 0.08320$&   $ 0.2830$&   $ 2.0900$&   $0.458$\tabularnewline
   ~~18&   $  7$&   $-0.5790$&   $-0.107000$&   $-0.004270$&   $-0.01460$&   $ 0.0972$&   $ 0.5000$&   $0.330$\tabularnewline
\rowcolor[gray]{.9}   ~~24&   $445$&   $-1.4100$&   $-0.115000$&   $ 0.113000$&   $ 0.18800$&   $ 0.4050$&   $ 2.4100$&   $0.531$\tabularnewline
   ~~30&   $ 11$&   $-0.9210$&   $-0.054200$&   $ 0.278000$&   $ 0.32500$&   $ 0.7370$&   $ 1.5900$&   $0.673$\tabularnewline
\rowcolor[gray]{.9}   ~~36&   $350$&   $-2.1400$&   $-0.103000$&   $ 0.154000$&   $ 0.26000$&   $ 0.5220$&   $ 2.5100$&   $0.616$\tabularnewline
   ~~42&   $  3$&   $-0.0931$&   $-0.046500$&   $ 0.000000$&   $ 0.00468$&   $ 0.0536$&   $ 0.1070$&   $0.100$\tabularnewline
\rowcolor[gray]{.9}   ~~48&   $245$&   $-2.1100$&   $-0.103000$&   $ 0.154000$&   $ 0.28600$&   $ 0.5820$&   $ 2.6200$&   $0.654$\tabularnewline
   ~~54&   $  6$&   $-0.1010$&   $ 0.231000$&   $ 0.427000$&   $ 0.52400$&   $ 0.7840$&   $ 1.3200$&   $0.507$\tabularnewline
\rowcolor[gray]{.9}   ~~60&   $119$&   $-1.0500$&   $-0.120000$&   $ 0.166000$&   $ 0.30800$&   $ 0.6530$&   $ 2.4000$&   $0.677$\tabularnewline
   ~~66&   $ 37$&   $-0.6610$&   $-0.066300$&   $ 0.226000$&   $ 0.40700$&   $ 0.7650$&   $ 1.9100$&   $0.654$\tabularnewline
\rowcolor[gray]{.9}   ~~72&   $ 64$&   $-1.1000$&   $-0.062600$&   $ 0.138000$&   $ 0.23000$&   $ 0.4970$&   $ 1.8300$&   $0.600$\tabularnewline
   ~~78&   $ 43$&   $-1.0200$&   $-0.109000$&   $ 0.132000$&   $ 0.29300$&   $ 0.5500$&   $ 2.2500$&   $0.717$\tabularnewline
\rowcolor[gray]{.9}   ~~84&   $ 58$&   $-1.3400$&   $-0.075100$&   $ 0.166000$&   $ 0.43700$&   $ 0.8380$&   $ 2.3000$&   $0.782$\tabularnewline
   ~~90&   $ 46$&   $-0.9950$&   $ 0.000000$&   $ 0.148000$&   $ 0.30100$&   $ 0.3550$&   $ 2.4000$&   $0.714$\tabularnewline
\rowcolor[gray]{.9}   ~~96&   $ 41$&   $-1.0800$&   $-0.037800$&   $ 0.122000$&   $ 0.47100$&   $ 0.8950$&   $ 2.3000$&   $0.799$\tabularnewline
   ~~102&   $ 35$&   $-1.2100$&   $-0.165000$&   $ 0.230000$&   $ 0.29900$&   $ 0.6140$&   $ 2.5100$&   $0.749$\tabularnewline
\hline
{\bfseries Dementia}&&&&&&&&\tabularnewline
\rowcolor[gray]{.9}   ~~108&   $ 36$&   $-0.5890$&   $-0.051600$&   $ 0.085400$&   $ 0.45700$&   $ 0.8660$&   $ 2.8200$&   $0.854$\tabularnewline
   ~~114&   $ 15$&   $-0.4090$&   $ 0.000693$&   $ 0.296000$&   $ 0.40600$&   $ 0.7120$&   $ 1.5600$&   $0.542$\tabularnewline
\rowcolor[gray]{.9}   ~~120&   $ 21$&   $-0.2600$&   $-0.052600$&   $ 0.026300$&   $ 0.19200$&   $ 0.2770$&   $ 2.0000$&   $0.534$\tabularnewline
   ~~126&   $  6$&   $-0.1990$&   $-0.110000$&   $ 0.378000$&   $ 0.54300$&   $ 1.1900$&   $ 1.5200$&   $0.765$\tabularnewline
\rowcolor[gray]{.9}   ~~132&   $  6$&   $-0.5140$&   $-0.185000$&   $ 0.285000$&   $ 0.32700$&   $ 0.8850$&   $ 1.1600$&   $0.687$\tabularnewline
   ~~3&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~6&   $130$&   $-2.5000$&   $-0.147000$&   $ 0.126000$&   $ 0.10500$&   $ 0.4100$&   $ 1.3300$&   $0.524$\tabularnewline
   ~~12&   $150$&   $-1.4600$&   $ 0.104000$&   $ 0.329000$&   $ 0.34300$&   $ 0.5900$&   $ 1.5700$&   $0.447$\tabularnewline
\rowcolor[gray]{.9}   ~~18&   $  4$&   $-0.6440$&   $-0.061300$&   $ 0.347000$&   $ 0.38700$&   $ 0.7950$&   $ 1.5000$&   $0.894$\tabularnewline
   ~~24&   $ 51$&   $-0.6490$&   $ 0.057800$&   $ 0.385000$&   $ 0.42200$&   $ 0.7740$&   $ 2.0800$&   $0.567$\tabularnewline
\rowcolor[gray]{.9}   ~~30&   $  4$&   $ 0.5790$&   $ 0.580000$&   $ 0.691000$&   $ 0.76600$&   $ 0.8770$&   $ 1.1100$&   $0.249$\tabularnewline
   ~~36&   $  1$&   $ 0.7560$&   $ 0.756000$&   $ 0.756000$&   $ 0.75600$&   $ 0.7560$&   $ 0.7560$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~42&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~48&   $  1$&   $ 0.7180$&   $ 0.718000$&   $ 0.718000$&   $ 0.71800$&   $ 0.7180$&   $ 0.7180$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~54&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
   ~~60&   $  3$&   $ 0.7180$&   $ 0.758000$&   $ 0.798000$&   $ 1.39000$&   $ 1.7200$&   $ 2.6400$&   $1.090$\tabularnewline
\rowcolor[gray]{.9}   ~~66&   $  1$&   $-0.2410$&   $-0.241000$&   $-0.241000$&   $-0.24100$&   $-0.2410$&   $-0.2410$&   $$\tabularnewline
   ~~72&   $  1$&   $ 1.1300$&   $ 1.130000$&   $ 1.130000$&   $ 1.13000$&   $ 1.1300$&   $ 1.1300$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~78&   $  3$&   $ 0.6750$&   $ 0.973000$&   $ 1.270000$&   $ 1.54000$&   $ 1.9700$&   $ 2.6600$&   $1.020$\tabularnewline
   ~~84&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~90&   $  1$&   $-0.0385$&   $-0.038500$&   $-0.038500$&   $-0.03850$&   $-0.0385$&   $-0.0385$&   $$\tabularnewline
   ~~96&   $  1$&   $ 1.5700$&   $ 1.570000$&   $ 1.570000$&   $ 1.57000$&   $ 1.5700$&   $ 1.5700$&   $$\tabularnewline
\rowcolor[gray]{.9}   ~~102&   $  0$&   $$&   $$&   $$&   $$&   $$&   $$&   $$\tabularnewline
\hline
\end{tabular}\end{center}
\end{table}

R Session Information

{r results = "markup" print(sessionInfo(), locale=FALSE)

ADNI1/GO/2 Enrollment

ATRI Biostatistics

ADNI enrollment summaries using the ADNIMERGE R package

Description

Load required R packages and functions

Demographic Summaries by Diagnosis

Baseline

Demographic Summaries by Diagnosis

Baseline

Baseline box plots

Baseline summary statistics

Longitudinal plots

R Session Information

Contents